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| Number | Title | Issue Date |
| 8183378 | Ligands, their preparation and uses thereof in asymmetric reactions Novel chemical agents are described herein. More a ligand of general Formula I: wherein R1, R2, R3 and R4, are independently selected from the group consisting of hydrogen, haloge... | 05/22/2012 |
| 7622586 | Opiate intermediates and methods of synthesis Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided. ... | 11/24/2009 |
| 7312222 | Heterocyclic piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases. ... | 12/25/2007 |
| 7309708 | Hepatitis C virus inhibitors Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds... | 12/18/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7074806 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, or a tautomer pr... | 07/11/2006 |
| 7041664 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands Disclosed are compounds of the formula: or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, wherein R1, R2, R3, X, Q1 and Q2 | 05/09/2006 |
| 6962997 | Process and intermediates for resolving piperidyl acetamide steroisomers Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers. ... | 11/08/2005 |
| 6949565 | Protein kinase inhibitors Novel isoquinoline derivatives which are useful as inhibitors of protein kinases for experimental, medical, and drug design purposes are disclosed. Preferred compounds which are specific inhibitors of protein kinase B are also disclosed. Furthermore, pharmaceutical ... | 09/27/2005 |
| 6875765 | Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized s... | 04/05/2005 |
| 6825213 | β3-adrenoreceptor agonists, agonist compositions and methods of using The invention provides β3-adrenoreceptor agonists, pharmaceutical compositions comprising β3-adrenoreceptor agonist compounds, and methods of using such compounds for stimulating, regulating or modulating metabolism of fats in adipose tissue ... | 11/30/2004 |
| 6809091 | Substances capable of inducing apoptosis A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and (d) [excluding uronic acid and/or uronic acid derivatives; and compou... | 10/26/2004 |
| 6784186 | Therapeutic compounds This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of opioid compounds, particularly morphine and related compounds, in whic... | 08/31/2004 |
| 6780998 | Substituted 2-aminoalkyl-1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of one or more coupler compounds and from 0.005 to 20.0 percent by weight of one or more developer compounds. The one or more developer compounds include at least one substitu... | 08/24/2004 |
| 6703392 | 1,2,3,4-tetrahydroisoquinoline derivatives The invention relates to novel 1,2,3,4-tetrahydroisochinoline derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the prepara... | 03/09/2004 |
| 6653321 | Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptabl... | 11/25/2003 |
| 6627641 | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining su... | 09/30/2003 |
| 6593341 | 댣-adrenoreceptor agonists, agonist compositions and methods of making and using the same The invention provides compounds useful as 댣 -adrenorecptor agonists and pharmaceutical compositions comprising such compounds. The invention further includes a method for stimulating, regulating, and modulating metabolism in fats of adi... | 07/15/2003 |
| 6573278 | Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in... | 06/03/2003 |
| 6509351 | Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity The present invention relates to compounds of formula (I): ##STR1## as well as the salts or solvates thereof, to pharmaceutical compositions containing them, to a process for preparing them and to synthetic intermediates in this process.... | 01/21/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6476226 | Isoxazoline fibrinogen receptor antagonists This invention relates to novel isoxazolines and isoxazoles of formula (I): ##STR1## or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein II... | 11/05/2002 |
| 6462044 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 10/08/2002 |
| 6420130 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe... | 07/16/2002 |
| 6417362 | Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein ... | 07/09/2002 |
| 6414154 | Tetraisoquinoline derivatives as modulators of dopamine D3 receptors ##STR1## Compounds of formula (I), wherein: R1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C1-4 alkyl,... | 07/02/2002 |
| 6331543 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donat... | 12/18/2001 |
| 6303785 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 3 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 10/16/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6265408 | Sulphonamide derivatives and their use in the treatment of CNS disorders Sulphonamide compounds according to formula (I) or pharmaceutically acceptable salts thereof: ##STR1## wherein: Ar is naphthyl, phenyl or thienyl optionally substituted by one or more substituents selected from the group consisting of C1-6 alky... | 07/24/2001 |
| 6239143 | 5-HT7 receptor antagonists The present invention relates to compounds having pharmacological activity toward the 5-HT7 receptor. Pharmaceutical compositions and methods for their use in the treatment of CNS disorders are described.... | 05/29/2001 |
| 6211196 | Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of liver cirrhosis or Alzheimer's disease. This application desc... | 04/03/2001 |
| 6184381 | Process for preparing optically active compounds This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmace... | 02/06/2001 |
| 6166219 | Benzimidazole derivatives Novel benzimidazole derivatives represented by the formula (I): ##STR1## wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceuticall... | 12/26/2000 |
| 6087346 | Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, neurological disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising ... | 07/11/2000 |
| 6063925 | Separation of enantiomers of octahydroisoquinoline This invention describes a process for the isolation of (-)1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline from a racemic mixture, which involves treating partially resolved mixtures with a formic acid to form a nearly-racemic salt for further r... | 05/16/2000 |
| 6043253 | Fused piperidine substituted arylsulfonamides as 댣-agonists Fused piperidine substituted arylsulfonamides are 댣 adrenergic receptor agonists with very little 댡 and 댢 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and ... | 03/28/2000 |
| 6015903 | Method of resolving racemic mixtures A process for resolving racemates of compounds of the formula I ##STR1## in which a, A, B, D, E, F, M, Q and R have the meanings given in the description is described. The process is carried in a manner known per se but using the optical antipodes of... | 01/18/2000 |
| 5994507 | Method for binding albumin and means to be used in the method A method for binding albumin by contacting an aqueous liquid containing an albumin with an albumin-binding compound is selected from albumin-binding compounds containing the scaffold --CO--NH--C(.dbd.C--)--CO--, and conjugates that are capable of binding ... | 11/30/1999 |
