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| Number | Title | Issue Date |
| 8008500 | Intermediates useful for making tetrabenazine compounds A method of preparing a tetrabenazine compound (TBZ compound) having structure I comprising the steps of reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide enone III. The protecting group P1 ... | 08/30/2011 |
| 7989626 | Modulators of cellular adhesion The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in... | 08/02/2011 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7300563 | Use of N-alllyl substituted amines and their salts as brightening agents in nickel plating baths An aqueous acidic plating bath for the electrodeposition of a nickel or nickel alloy deposit. The bath includes nickel ions and an additive having the general formula: H2C═CHCH2NR1R2 or [H2... | 11/27/2007 |
| RE39888 | Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hy... | 10/16/2007 |
| 7268135 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/11/2007 |
| 7247644 | Ester derivatives of a decahydroisoquinoline-3-carboxylic acid as analgestics Thus, the present invention provides compounds of formula (I) The present invention further provides the use of a compound of formula (I) for the manufacture of a medicament for the treatment of a neurological disorder. The present invention further provides the use... | 07/24/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7157582 | Selective iGluRreceptor antagonists The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5 receptor antagonist. The present invention further provides novel compounds function... | 01/02/2007 |
| 7151175 | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suit... | 12/19/2006 |
| 7122673 | Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents A method for the preparation of a compound of general Formula: or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general... | 10/17/2006 |
| 7105564 | Pharmaceutical composition comprising a dual antagonist against PGD/TXAreceptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D2 receptor and pharmaceutical compositions comprising them. A compound of the formula (I): | 09/12/2006 |
| 7104584 | Seat slide device for vehicle A seat slide device for a vehicle being a width of the seat slide device in the horizontal direction is smaller than the width of the seat slide device in the vertical direction includes a guide rail extending in the back/forth direction of a vehicle seat, including... | 09/12/2006 |
| 7060707 | Isoquinoline derivatives Isoquinoline derivatives of the general formula (I) in which X, Y, Z, R1, R2 and n are as defined in Patent Claim (1), and physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be employed for combating th... | 06/13/2006 |
| 7053057 | Caspase inhibitors and uses thereof This invention provides caspase inhibitors having the formula: wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R1 is hydrogen, CHN2 | 05/30/2006 |
| 7026485 | Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 04/11/2006 |
| 7022677 | Amide derivatives as growth hormone secretagogues Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubs... | 04/04/2006 |
| 7015323 | Thiocarbamate inhibitors of alpha-4 integrins The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1 | 03/21/2006 |
| 6972287 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well... | 12/06/2005 |
| 6924294 | Excitatory amino acid receptor antagonists The present invention provides novel compounds of Formula (I), or the pharmaceutically acceptable salts or prodrugs thereof, and methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine. ... | 08/02/2005 |
| 6884821 | Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydro... | 04/26/2005 |
| 6872732 | Heterocyclic derivatives and medicinal use thereof The novel heterocyclic derivative of the present invention is a novel heterocyclic derivative having the formula (I′) wherein R1 is a hydrogen atom or C1-6 alkyl, R2 is —CO—C(R | 03/29/2005 |
| 6858735 | Preparation of quinapril hydrochloride Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)-1,2,3,4-te... | 02/22/2005 |
| 6855823 | Selective iGluR5 receptor antagonists The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5 receptor antagonist. The present invention further provides novel compounds function... | 02/15/2005 |
| 6855725 | Excitatory amino acid receptor antagonists The present invention provides compounds of Formula I or Formula II, or the pharmaceutically acceptable salts or prodrugs thereof, pharmaceutical compositions comprising compounds or Formula I or Formula II, and methods for treating neurological disorders and neurod... | 02/15/2005 |
| 6825213 | β3-adrenoreceptor agonists, agonist compositions and methods of using The invention provides β3-adrenoreceptor agonists, pharmaceutical compositions comprising β3-adrenoreceptor agonist compounds, and methods of using such compounds for stimulating, regulating or modulating metabolism of fats in adipose tissue ... | 11/30/2004 |
| 6818774 | Isoquinoline derivatives Disclosed are isoquinolino derivatives of the formula wherein Y is >C═O or —CH2—, Z is >C═O or —CH2—, and R1, R2 and m are as defined herein as well as the pharma... | 11/16/2004 |
| 6759418 | Selective iGluR5 receptor antagonists for the treatment of neurological disorders The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5 receptor antagonist. The present invention further provides novel compounds function... | 07/06/2004 |
| 6747042 | N-heterocyclic derivatives The present invention relates N-heterocyclic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compo... | 06/08/2004 |
| 6642384 | Preparation of chiral 1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid and derivatives The present invention relates to a process for the production of (S)-1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid compounds (1) and their derivatives from Levodopa (L-Dopa). The ultimately prepared compounds are used as intermediates for,... | 11/04/2003 |
| 6627641 | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining su... | 09/30/2003 |
| 6620938 | Compounds that inhibit GRB2-SHC binding and process for preparing same A novel compound of the formula(I) having a high inhibitory activity against Grb2-Shc binding may be useful for the prevention and treatment of intracellular signal transmission-related diseases. ##STR1##... | 09/16/2003 |
| 6617457 | Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropa... | 09/09/2003 |
| 6608203 | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists This invention relates to compounds useful for treating or preventing obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease, prostatic disease, and the like, and to pharmaceutical composition, methods, and kits comprising such compou... | 08/19/2003 |
| 6596732 | 1,3-dihydro-2h-indol-2-one, preparation method and pharmaceutical compositions containing same The invention relates to compounds of formula: ##STR1## and their solvates and/or hydrates exhibiting an affinity and a selectivity for arginine-vasopressin V1b receptors or for both V1b and V1a receptors.... | 07/22/2003 |
| 6589963 | Heterocyclic compounds and salts thereof and medicinal use of the same A heterocyclic compound of the formula [I] ##STR1## wherein R1 is hydrogen atom or lower alkyl, R2 is hydrogen atom, alkyl optionally having a substituent and the like, R3 is hydrogen atom, lower alkyl and the like, A is a... | 07/08/2003 |
| 6583139 | Compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed as compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g.,... | 06/24/2003 |
| 6566370 | Selective iGluR5 receptor antagonists for the treatment of migraine The present invention provides a method of treating or preventing migraine comprising administering to a patient in need thereof an effective amount of a selective iGluR5 receptor antagonist. The present invention further provides novel compoun... | 05/20/2003 |
| 6541635 | Method for producing angiotensin converting enzyme inhibitor The present invention discloses a method for producing angiotensin converting enzyme inhibitor of the following formula (I) and pharmaceutically acceptable salts thereof, in which a compound of the following formula (II), ##STR1## wherein R and R | 04/01/2003 |
