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| Number | Title | Issue Date |
| 5260316 | Isoquinolyl substituted hydroxylamine derivatives The compounds of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C3 -C7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl, aryloxy-lower alkyl, arylthio-lower alkyl; C3 | 11/09/1993 |
| 5256783 | Method for producing 2-isoquinoline compounds 1,2,3,4-Tetrahydro-2-isoquinoline-derivatives of the formula ##STR1## wherein R signifies hydroxy, lower alkylamino, lower alkoxy or phenyl-C2-6 -alkoxy which can carry one or more lower alkyl or lower alkoxy substituents on the phenyl rin... | 10/26/1993 |
| 5254564 | Substituted isoquinoline compounds, pharmaceutical composition and method of use in treating pain in mammals A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R1 and R2 are ... | 10/19/1993 |
| 5246943 | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhance... | 09/21/1993 |
| 5244915 | Amico acid derivatives cyclized at the C-terminal Novel -substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds ar... | 09/14/1993 |
| 5244895 | Anti-ulcer agent An anti-ulcer agent contains a compound expressed by the following general formula 1: ##STR1## where, R1 is hydrogen atom or an alkyl group having 1 or 2 carbon atoms with or without substitution, R2 and R3 are resp. ... | 09/14/1993 |
| 5242939 | Anilide derivatives with angiotensin II antagonist properties This invention relates to anilide derivatives of Formula I ##STR1## which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods o... | 09/07/1993 |
| 5243048 | Antipsychotic 1-cycloalkylpiperidines There are provided cycloalkyl piperidine compounds which are useful in the treatment of physiological or drug-induced psychosis or dyskinesia in a mammal. These novel compounds are selective sigma receptor antagonists and have a low potential for movement... | 09/07/1993 |
| 5238935 | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diph... | 08/24/1993 |
| 5235072 | 2-oxabicyclo(2,2,1)heptane derivatives and pharmaceutical The invention relates to 2-oxabicyclo[2.2.1]heptane derivatives of formula I ##STR1## as well as their enantiomers, in which, e.g., A means --(CH2)n --, (E)-- or (Z)--CH.dbd.CH--, --C.tbd.C, --O-- or --S--, B means hydrogen, C | 08/10/1993 |
| 5232928 | Tetrahydroisoquinoline amides Tetrahydroisoquinoline amides having the general structure ##STR1## are disclosed, the substituents defined hereinbelow, which amides are useful in inhibiting human leukocyte and neutrophil elastaes.... | 08/03/1993 |
| 5229403 | Diaminotrifluoromethylpyridine derivatives and phospholipase A2 inhibitor containing them A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW1 R1, --COCOR2, --CW1 NHCOR2, --C(.dbd.W1 (W2 W3 or --CW1 | 07/20/1993 |
| 5223517 | Heterocyclically substituted cycloalkano[b]-indolesulphonamides Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or amidation, or by reaction of heterocyclically substituted hydr... | 06/29/1993 |
| 5223489 | Amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same A compound of the formula: ##STR1## wherein R1 is lower alkyl optionally substituted aryl; or amino optionally substituted; and R2 is hydrogen or lower alkyl; or R1 and R2 are taken together with the attached ni... | 06/29/1993 |
| 5221677 | 5-lipoxygenase inhibitors quinoline or isoquinoline derivatives The invention concerns a heterocyclic derivative of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; X1 is oxy, thio, sulp... | 06/22/1993 |
| 5214206 | Aminosulfonyl urea ACAT inhibitors The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels, pharmaceutical compositions and methods of using the ACAT inhi... | 05/25/1993 |
| 5208243 | 5-isoquinolinesulfonamides Compounds of formula (I): ##STR1## with R1, R2, U, X, Y, Z, n, m, p and r as defined in the description. Medicinal products.... | 05/04/1993 |
| 5204357 | Renin-inhibiting amino acid derivatives The invention relates to compounds of the formula I ##STR1## in which A represents a substituted thio-, sulfinyl- or sulfonyl-alkanoyl radical or a four- to eleven-membered heterocycle, B is an amino acid residue, R1 denotes hydrogen (subs... | 04/20/1993 |
| 5200416 | Cyclic amides Compounds of the formula ##STR1## wherein: R1, R2, R3, R4, R6, and R7 are independently hydrogen or lower alkyl. R5 is hydrogen, lower alkyl, rad alkanoyl having 1 to 6 carbon at... | 04/06/1993 |
| 5189049 | Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them Compounds of formula ##STR1## in which R1 represents H, an alkyl or a substituted alkyl, R2 represents H or alkyl and R3 represents an optionally substituted cycloalkyl or an optionally substituted aromatic group, whi... | 02/23/1993 |
| 5187158 | Brain-specific drug delivery The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula [D-DHC] (I) wherein [D] is a centrally acting drug... | 02/16/1993 |
| 5185335 | N-(4-piperodinyl)(dihydrobenzofuran or dihydro-2H-benzopyran) carboxamide derivatives Piperidine derivatives of formula ##STR1## wherein A is a radical of formula ##STR2## wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C1-6 alkyl radical; R1 is hydrogen or halo; R... | 02/09/1993 |
| 5169948 | Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors This invention relates to a process for producing spiro-isoquinolinepyrrolidines. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.... | 12/08/1992 |
| 5162335 | Di- and tetrahydroisoquinoline derivatives The invention relates to new di- and tetrahydroisoquinoline derivatives having interesting cytostatic properties, to the preparation of the said new compounds, and to compositions comprising such a compound as a cytostatically active substance.... | 11/10/1992 |
| 5157041 | Amino acid derivatives Compounds of the formula ##STR1## wherein R1 is alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, cycloalkylcarbonyl, aralkanoyl, aroyl, heterocyclylcarbonyl, alkylsulphonyl, arylsulphonyl, monoaralkylcarbamoyl, cinnamoyl or -aralkox... | 10/20/1992 |
| 5155227 | Compounds for site-enhanced delivery of radionuclides A dihydropyridine.revreaction.pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radionuclide to the brain. A chelating agent capable of chelating with a radionuclide and having a reactive ... | 10/13/1992 |
| 5147883 | Acylbenzoxazolinones compounds Compounds of general formula (I): ##STR1## in which: R1 represents a hydrogen atom or a lower alkyl group, A represents a hydrogen atom, and in this case B represents a group CO-G, G being: either a heteroaryl group selected from furan, indole,... | 09/15/1992 |
| 5142048 | Intermediate for preparation of amino acid derivatives The invention relates to novel intermediate compounds for preparation of novel amino acid derivatives having renin inhibiting activity.... | 08/25/1992 |
| 5138067 | Lipid derivatives Lipid derivatives represented by the formula: ##STR1## wherein R1 is alkyl or alkylcarbamoyl; R2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkylox... | 08/11/1992 |
| 5136038 | Radiopharmaceuticals and chelating agents useful in their preparation A dihydropyridine.revreaction. pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radionuclide to the brain is provided. A chelating agent capable of chelating with a radionuclide and havin... | 08/04/1992 |
| 5124337 | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diph... | 06/23/1992 |
| 5122610 | Aminomethyl peptides Renin-inhibiting aminomethyl peptides of the formula ##STR1## in which A is H, an alkyl radical, a sulphony radical or an amino-protecting group, B, D, E and F each independently is a direct bond or an amino-organo-carbonyl group, R1 is an... | 06/16/1992 |
| 5122537 | Arylvinylamide derivatives and pharmaceutical use The invention relates to new arylvinylamide derivatives of formula ##STR1## wherein Y is a bicyclic ring system chosen from (A), (B), (C), (D), and (E); ##STR2## in which m is zero, 1 or 2; R is hydrogen, a C1 -C6 alkyl or... | 06/16/1992 |
| 5120745 | 1-dimethylcarbamoyl-3-substituted-5-substituted-1H-1,2,4-triazoles This invention relates to 1-dimethylcarbamoyl-3-substituted-5-substituted-1H-1,2,4-triazoles of the formula ##STR1## wherein the substituents are as defined herein, compositions containing those compounds and methods of use.... | 06/09/1992 |
| 5114940 | Pesticides Compound of the formula (I) are disclosed ArQQ1 C(.dbd.X)NHR1 (I) or a salt thereof, wherein Ar is an optionally substituted polycyclic ring system containing n rings, where n is the integer 2 or 3, at least n-1 ... | 05/19/1992 |
| 5112832 | Certain cyclopenta[b]pyridines and 5,6,7,8-tetrahydroquinolines having anti-inflammatory activity The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R1 and R2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl... | 05/12/1992 |
| 5109002 | Antipsychotic 1-cycloalkylpiperidines There are provided cycloalkyl piperidine compounds which are useful in the treatment of physiological or drug-induced psychosis or dyskinesia in a mammal. These novel compounds are selective sigma receptor antagonists and have a low potential for movement... | 04/28/1992 |
| 5104883 | Thioformamide derivatives Thioformamide derivatives of the formula: ##STR1## wherein: R represents alkyl; A represents an optionally substituted phenyl or heteroaromatic group; R1 represents hydrogen, alkyl, cyano, carboxyl, formyl, carbamoyl, alkoxycarbonyl or a g... | 04/14/1992 |
| 5100904 | Prolinal compounds which are useful in treating amnesia A novel prolinal derivatives of the general formula: ##STR1## [wherein A represents alkylene or alkenylene group of from 1 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents hydrogen atom, phenyl group, benzyl gr... | 03/31/1992 |
| 5089507 | Heterocyclic piperidinyl compounds having analgesic effect A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring; R1 and R2 are independ... | 02/18/1992 |
