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A Receptacle for supporting, rotating and sculpting a portion of ice cream or similarly malleable food while it is being consumed.
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| Number | Title | Issue Date |
| 7432281 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals ... | 10/07/2008 |
| 7429664 | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of ... | 09/30/2008 |
| 7423049 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 09/09/2008 |
| 7417056 | 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents. ... | 08/26/2008 |
| 7371763 | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy. ... | 05/13/2008 |
| 7368572 | Acetylene derivatives as inhibitors of histone deacetylase The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin... | 05/06/2008 |
| 7361663 | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing Factor Xa. The present invention is also directed to compositions cont... | 04/22/2008 |
| 7354914 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifica... | 04/08/2008 |
| 7329657 | Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am... | 02/12/2008 |
| 7329753 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors. ... | 02/12/2008 |
| 7307088 | Substituted anthranilic amide derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods fo... | 12/11/2007 |
| 7304060 | Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or am... | 12/04/2007 |
| 7304049 | Succinoylaminobenzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 12/04/2007 |
| 7285563 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R... | 10/23/2007 |
| 7268142 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to in... | 09/11/2007 |
| 7265130 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ... | 09/04/2007 |
| 7241775 | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines Substituted 4-phenyltetrahydroisoquinolines of formula I, process for their preparation, their use as a medicament and medicaments containing them. The compounds of formula I can be used, among other uses, in the e... | 07/10/2007 |
| 7238707 | Substituted pentanols, a process for their production and their use as anti-inflammatory agents The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents. ... | 07/03/2007 |
| 7229986 | Melanin-concentrating hormone antagonist A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms... | 06/12/2007 |
| 7205314 | Compounds for the treatment of dementia related diseases The present invention relates to new compounds of formula (I) wherein Y, P, R1, R2, R3, n, m are defined as in claim 1, a process for their preparation and new intermediates used therein, pharmaceutical composition containing ... | 04/17/2007 |
| 7202253 | Cycloalkyl inhibitors of potassium channel function Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating... | 04/10/2007 |
| 7202257 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel com... | 04/10/2007 |
| 7199133 | Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors Novel compounds of formula (I), wherein D, W, X, Y, T and R1 have the meanings cited in claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors | 04/03/2007 |
| 7183411 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflamma... | 02/27/2007 |
| 7176228 | Pyrazole biphenylcarboxamides The invention relates to biphenylcarboxamides of the formula (I) in which A, R, Z, X, Y, m and n are each as defined in the disclosure, to a plurality of processes for preparing these sub... | 02/13/2007 |
| 7163949 | 4-phenyl substituted tetrahydroisoquinolines and use thereof Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1–R8 for compounds of each of the formulae IA, IB, I... | 01/16/2007 |
| 7144895 | Benzene acetamide compounds useful as serine protease inhibitors Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, or prodrugs thereof, are useful as serine protease inhibitors, wherein X is —OH, —O(alkyl), —O(aryl), —O(arylalkyl), —N... | 12/05/2006 |
| 7125891 | Tripeptidyl peptidase inhibitors The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for ... | 10/24/2006 |
| 7122559 | Phenylglycine derivatives useful as serine protease inhibitors Compounds having the formula (I), or a stereoisomer or pharmaceutically-acceptable salt, or hydrate thereof, are useful as factor VIIa inhibitors, wherein X is —NR6S(O)pR16; W i... | 10/17/2006 |
| 7122673 | Preparation of fused polycyclic alkaloids by ring closure of azomethine ylides, novel compounds thereof and their use as chemotherapeutic agents A method for the preparation of a compound of general Formula: or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general... | 10/17/2006 |
| 7109212 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors. ... | 09/19/2006 |
| 7105536 | Compounds The invention relates to novel isoquinolines and their use as anticonvulsants and in the treatment of a variety of disorders. ... | 09/12/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7094789 | 5-substituted isoquinoline derivatives A compound represented by the following formula (1) or a salt thereof: wherein R1 represents hydrogen atom, a halogen atom and the like; R2 represents hydrogen atom, a halogen atom, a C... | 08/22/2006 |
| 7087603 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula IV: wherein Z1 or Z2 is nitrogen, Q is —S—, —O—, —N(R4)—, —C(R6′)2—, 1,2-cyclo... | 08/08/2006 |
| 7074805 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor The isoquinoline compounds of formula (I) are VR1 antagonists that are useful in treating pain, inflammation, thermal hyperalgesia, urinary incontinence and bladder over activity. The “R”, “Z” and “L” varia... | 07/11/2006 |
| 7053084 | Succinoylamino benzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 05/30/2006 |
| 7041640 | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents A method of increasing the bioavailability upon oral administration of a pharmacologically active target agent, particularly an antitumor or antineoplastic agent which exhibits poor or inconsistent oral bioavailability (e.g., paclitaxel, docetaxel or etoposide), com... | 05/09/2006 |
| 7015233 | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity. ... | 03/21/2006 |
| 7012081 | Anthranyl amides and their use as medicaments Substituted anthranilamides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis as well as their intermediate products for the production of anthranilamides are described. ... | 03/14/2006 |
