Class 546/141 - Chalcogen attached directly to the six-membered hetero ring by nonionic bonding

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 543
Last issue date: 04/24/2012

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Number	Title	Issue Date
8163921	Hepatitis C virus inhibitors Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed. ...	04/24/2012
7572913	4-substituted piperidine derivatives Substituted piperidine compounds represented by the structure I are provided, wherein each of R1a, R1b, R1c, R1d, R1e, R1f, R1g, R1h, R...	08/11/2009
7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R...	10/28/2008
7439242	PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ...	10/21/2008
7425563	4-(Substituted aryl)-5-hydroxyisoquinolinone derivative The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase. 4-Substituted aryl-5-hydroxyisoquinolinone derivatives, repre...	09/16/2008
7405227	Treatment of cancer Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma...	07/29/2008
7402595	JNK inhibitor A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O�...	07/22/2008
7402596	Bicycloheteroaryl compounds as P2X7 modulators and uses thereof Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cond...	07/22/2008
7402673	Diamine βadrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor...	07/22/2008
7390820	Substituted quinolinone derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods fo...	06/24/2008
7348339	Imidazopyridine derivatives as kinase inhibitors A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; ...	03/25/2008
7329753	Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors. ...	02/12/2008
7314937	Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodim...	01/01/2008
7294635	Substituted isoquinolinones Isoquinolinone compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders. ...	11/13/2007
7265131	Isoquinolinone derivatives and their use as therapeutic agents Compounds of formula (I): wherein n, R1, R2, R3 and R7 are disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceut...	09/04/2007
7265130	NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ...	09/04/2007
7253160	Depeptidized inhibitors of hepatitis C virus NS3 protease The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. ...	08/07/2007
7244845	Process for preparing cyclic N-substituted alpha-imino carboxylic acids The present invention relates to the novel methods of making matrix metalloproteinase inhibitors of Formula (I): ...	07/17/2007
7238683	Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is in...	07/03/2007
7220759	Isoquinoline compound and pharmaceutical use thereof The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for...	05/22/2007
7214689	Isoquinoline compounds The invention relatests compound of formula (I): wherein: n is 1, 2 or 3, A represents a group	05/08/2007
7205315	Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an inhibitor of matrix metalloproteinase. The present invention is also dir...	04/17/2007
7196088	Substituted tetrahydroisoquinolines and uses thereof The invention provides compounds of the formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein, n, X, Y, R1, R2, R3, R4 and R5 are as de...	03/27/2007
7166617	Cyclic amide derivatives Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an a...	01/23/2007
7153963	Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin ...	12/26/2006
7144894	Sulfonamide bicyclic compounds The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their uses in inhibiting β-amyloid peptide (β-AP) production ...	12/05/2006
7126001	Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperid...	10/24/2006
7125863	Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t...	10/24/2006
7122672	Quinolin-, isoquinolin-, and quinazolin-oxyalkylamides and their use as fungicides Fungicidal compounds of the general formula (1) wherein one of X and Y is N or N-oxide and the other is CR or both of X and Y are N ...	10/17/2006
7109212	Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors. ...	09/19/2006
7105701	β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor....	09/12/2006
7101676	Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labe...	09/05/2006
RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound...	09/05/2006
7091378	Preparation of hydroxamic acids from esters in solution and on the solid phase The present invention provides a novel method for the formation of hydroxamic acids comprising reacting under suitable conditions an ester with hydroxylamine in the presence of cyanide anion. ...	08/15/2006
7070937	Marker useful for detection and measurement of free radical damage and method The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presenc...	07/04/2006
7053211	Process for the preparation of α-aminosubstituted carboxylic acid amides The invention relates to a process for the preparation of α-aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amide of a primary amine with a nitrosylating agent in the presence of a base followed by hydrolysi...	05/30/2006
7041676	Compounds, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ...	05/09/2006
7034039	Fused heterocyclic compounds The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally s...	04/25/2006
6998408	6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors The present application describes 6–5, 6—6, or 6–7 heterobicycles of Formula I or pharmaceutically acceptable salt forms thereof: wherein ring P is a 6-membered heteroaromatic and ring M is a 5-, 6-, or 7-membered...	02/14/2006
6998401	Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or...	02/14/2006

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Class 546/141 - Chalcogen attached directly to the six-membered hetero ring by nonionic bonding