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| Number | Title | Issue Date |
| 5834499 | 5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof A 5-HT3 receptor against containing a thiazole derivative as the effective ingredient is provided and is represented by the Formula (I): ##STR1## wherein the A ring is substituted or unsubstituted and represents a benzene or a heterocyclic... | 11/10/1998 |
| 5830902 | Quinuclidine derivative having tricyclic hetero condensed ring A quinuclidine derivative represented by the following general formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, which has strong squalene synthase inhibiting activity and is useful as a cholesterol lowering ... | 11/03/1998 |
| 5807867 | Quinuclidine derivatives Compounds of the formula ##STR1## wherein R1 is methoxy and R2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl; and the pharmaceutically acceptable salts of such compounds. These compo... | 09/15/1998 |
| 5808075 | Process for the preparation of azabicyclic derivatives A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 represents (a) in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R2 is a group... | 09/15/1998 |
| 5795890 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 08/18/1998 |
| 5792777 | Biphenyl quinuclidines Biphenylylquinuclidine compounds of the formula I: ##STR1## and pharmaceutically-acceptable salts thereof; wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR... | 08/11/1998 |
| 5780466 | Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 07/14/1998 |
| 5777122 | Enantiomerically pure quinuclidine derivatives and methods for their production and use A process for cleaving cinchona alkaloids to a quinoline derivative and an enantiomerically pure, functionalized 1-azabicyclo(2.2.2)octane, includes treating a cinchona alkaloid with a complex metal hydride while simultaneously oxidizing by exposure to ai... | 07/07/1998 |
| 5773619 | Process for the preparation of azabicycloc derivatives A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 represents ##STR2## in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 ... | 06/30/1998 |
| 5773458 | 1-azabicycloheptane derivatives The compound of the formula: ##STR1## where R is H, alkyl, haloalkyl, cycloalkyl, alkenyl or alkynyl; Y is oxygen, sulfur or NR2 where R2 is H or alkyl; or a pharmaceutically acceptable salt thereof, are centrally active muscari... | 06/30/1998 |
| 5770608 | Heterocyclic derivatives Quinuclidine compounds of the formula I: ##STR1## R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1 --CR2 is a double bond; X is selected from --CH | 06/23/1998 |
| 5767141 | Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the meanings stated in the description, a process for the pre... | 06/16/1998 |
| 5744606 | Process for the preparation of optically active 3-quinuclidinol Optically active 3-quinuclidinol is obtained by the asymmetric hydrogenation of 3-quinuclidinone, its Lewis acid adducts or its tertiary or quaternary salts, for example, 1-(diphenylmethyl)-3-oxoquinuclidinium bromide. Rhodium/chiral diphosphine complexes... | 04/28/1998 |
| 5741797 | Heteroatom substituted alkyl benzylaminoquinuclidines Compounds useful in the treatment of inflammatory disorders, central nervous system disorders and other disorders of the formula I and the pharmaceutically-acceptable salts thereof; ##STR1## wherein R is C1 -C6 alkyl; X is C | 04/21/1998 |
| 5741819 | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compoun... | 04/21/1998 |
| 5731323 | Quinuclidine derivatives as squalene synthase inhibitors Compounds of formula (I) and their pharmaceutically acceptable salts in which R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1 --CR2 is a double bond; ... | 03/24/1998 |
| 5726313 | Substituted arylaliphatic compounds, method of preparing them and pharmaceutical compositions in which they are present Compound of Formula (I), wherein W1 is an oxygen atom; an --NR-- group wherein R is hydrogen, C1 -C7 alkyl or benzyl; and B is for example a substituted piperidine or quinuclidine. The disclosed compounds are useful as neu... | 03/10/1998 |
| 5723103 | Substituted benzamides and radioligand analogs and methods of use This invention provides compounds of the formula I ##STR1## wherein, R1, R2, and R3 are independently a first halogen atom,! fluorine, chlorine, bromine, iodine, alkyl, alkenyl, alkynyl, alkoxy, alkenoxy, or alkynox... | 03/03/1998 |
| 5716965 | Substituted 3-aminoquinuclidines Compounds of the formula ##STR1## wherein W, Ar1, Ar2 and Ar3 are defined as below; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of ... | 02/10/1998 |
| 5714496 | Quinuclidine derivatives as squalene synthase inhibitors Compounds of formula (I) and their pharmaceutically acceptable salts in which R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1 -CR2 is a double bond; X ... | 02/03/1998 |
| 5712288 | Quaternary basic amides, method of preparing them and pharmaceutical compositions in which they are present The invention relates to quaternary basic amides of the formula ##STR1## in which Ar is an optionally substituted mono-, di- or tri-cyclic aromatic or heteroaromatic group; T is a direct bond, a hydroxymethylene group, an alkoxymethylene group in whi... | 01/27/1998 |
| 5712270 | 2-arylamidothiazole derivatives with CNS activity This invention relates to methods of treating neurological illnesses related to acetylcholine deficiency in the CNS including memory loss attending senility, Parkinson's disease, Down's syndrome or senile pugilistica by administering a therapeutically eff... | 01/27/1998 |
| 5710191 | Hydroxymethyl quinuclidine catalyst compositions for making polyurethane foams A method for preparing a polyurethane foam which comprises reacting an organic polyisocyanate and a polyol in the presence of a blowing agent, a cell stabilizer and a catalyst composition comprising at least one compound of either of the following formula... | 01/20/1998 |
| 5691349 | Quinclidine derivatives as squalene synthase inhibitors Quinuclidine derivatives of formula, and their pharmaceutically acceptable salts, in which: R1 is hydrogen or hydroxy; R2 is hydrogen; pr R1 and R2 are joined together so that CR1 -CR2 is a ... | 11/25/1997 |
| 5686461 | Indole derivatives The invention relates to compounds of formula (I). ##STR1## or a salt, or metabolically labile ester thereof wherein R1 represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, tri... | 11/11/1997 |
| 5686463 | Oxadiazoles useful in the treatment of senile dementia A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring, and substituted on the other ring carbon atom with a substituent of low lipophilicity; are potent muscarinic agonists, and have go... | 11/11/1997 |
| 5662828 | Compound having unsaturated side chain, process for preparing the same, liquid crystalline polymer prepared from the same, liquid crystal mixture and display element A compound having an unsaturated side chain represented by the formula: ##STR1## in which A and B are the same and different and represent an aromatic or heterocyclic group or either one of A and B represents a single bond; X1, X2 | 09/02/1997 |
| 5658925 | Aminobenzoic acid derivatives To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically accepta... | 08/19/1997 |
| 5656639 | Heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; n is 0, 1 or 2; Am is ##STR2## R1 is a (C1 -C4)-alkyl or a benzyl; R2 is a substituted or unsubstituted phenyl; x is ze... | 08/12/1997 |
| 5654315 | Quinuclidine compounds useful in treating diseases Quinuclidine compounds of the formula I: ##STR1## R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1 --CR2 is a double bond; X is selected from --CH | 08/05/1997 |
| 5643923 | Quinuclidinyloxy-isoxazole compounds and their therapeutic uses Compounds of formula (I): ##STR1## wherein R1 is hydrogen, halogen or alkyl; R2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R1 and R2 together form a group of formula --CR4 | 07/01/1997 |
| 5641777 | Substituted heterocyclic compounds and pharmaceutical compositions in which they are present The invention relates to neurokinin receptor antagonist compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4... | 06/24/1997 |
| 5637596 | Azabicycloalkyl derivatives of imidazo[1,5-a]indol-3-one and process for their preparation Novel 5-HT3 receptor antagonist compounds having the general formula (I) ##STR1## wherein each of R, R1 and R2, which may be the same or different, is hydrogen, halogen, hydroxy, cyano, C1 -C6 al... | 06/10/1997 |
| 5614629 | Benzyl quaternary tropinium compound This invention is directed to novel benzyl quaternary ammonium compounds and their synthesis. The compounds have valuable utility as organic directing agents in the crystallization of a silicate structure which, in turn, is useful as a catalyst component,... | 03/25/1997 |
| 5612352 | Heterocyclic compounds Biphenylylquinuclidine derivatives of formula I, Q--Ar1 --Ar2, in which Q is of formula Ia or Ib, ##STR1## in which R1 and R2 are independently selected from hydrogen, alkyl, halogeno and hydroxy; or R... | 03/18/1997 |
| 5612336 | Heterocyclic amide derivatives as tachykinin antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q1 is phenyl substituted by one or more halo; optionally substituted naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or fluorenyl; the dotted line represents an optional... | 03/18/1997 |
| 5605908 | Heterocyclic compounds and their use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 02/25/1997 |
| 5604241 | Substituted benzylaminoquinuclidines as substance P antagonists Compounds useful in the treatment of inflammatory disorders, central nervous system disorders and other disorders of the formula I ##STR1## and the pharmaceutically-acceptable salts thereof, wherein Ar1 and Ar2 are each independ... | 02/18/1997 |
| 5599937 | Heteroaromatic quinuclidinenes, their use and preparation The invention relates to novel compounds of general formula (I), wherein R is a group of general formula (II) or (III), where X1 represents oxygen or sulphur and Y1 and Z1 both represent carbon, or X1 represents... | 02/04/1997 |
| 5591748 | Immunomodulatory azaspiranes Invented are substituted azaspirane compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to induce an immunosuppressive effect in a mammal in need thereof.... | 01/07/1997 |
