Famous Patents
In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7345037 | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF i... | 03/18/2008 |
| 7291628 | Treatment of cocaine abuse using N-substituted derivatives of morphinan The invention is based in part on the discovery that nonselective κ agonists that possess μ receptor-mediated effects in addition to their κ agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can... | 11/06/2007 |
| 7094788 | Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions The present invention relates to new compounds of general formula 1 wherein X− and the groups A, B, R, R1, R2, R3, R3′, R4, R4′, ... | 08/22/2006 |
| 7041674 | Carbamic acid esters with anticholinergic activity A compound of formula 1 wherein X−, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their... | 05/09/2006 |
| 6964972 | 8-Azabicyclo(3,2,1)oct-2 ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors The invention disclosed herein relates to novel a 8-azabicyclo[3.2.1]oct-2-ene compound of Formula II, wherein R is hydrogen, methyl, ethyl or benzyl; and R1 is 3-thienyl, 2-thienyl... | 11/15/2005 |
| 6852728 | Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them A compound of formula 1 wherein: A is a group selected from X− is an anion with a single negative charge; R1 and R | 02/08/2005 |
| 6790857 | Benzoylecgonine compositions and methods for producing them This invention provides a method for preparing a benzoylecgonine composition comprising the steps of: (a) contacting benzoylmethylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture; (b) maintaining the reaction... | 09/14/2004 |
| 6706726 | Anticholinergics which may be used as medicaments as well as processes for preparing them The present invention relates to new anticholinergics of general formula 1: wherein A, X− and the groups R1, R2, R3, R4, R5, R6 and R7 | 03/16/2004 |
| 6680328 | 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be use... | 01/20/2004 |
| 6645977 | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ACh receptors The present invention discloses compounds of formula (1) any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein - - - - is a single or a double bond; R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, #... | 11/11/2003 |
| 6541004 | Cocaethylene immunogens and antibodies The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for production of antisera and monoclonal antibodies. The antise... | 04/01/2003 |
| 6486323 | Process for producing optically active tropinonemonocarboxylic acid derivative An optically active tropinonemonocarboxylic acid ester derivative useful as an intermediate for synthesis of optically active tropane derivatives was obtained by reacting succindialdehyde with an organic amine and acetonedicarboxylic acid ester to obtain ... | 11/26/2002 |
| 6482831 | Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tiss... | 11/19/2002 |
| 6383490 | Anti-cocaine vaccine An anti-cocaine vaccine employs a cocaine hapten conjugated to a carrier protein. The anti-cocaine vaccine elicits an immune response which reduces the psychoactive effects of cocaine consumption by the production of anti-cocaine polyclonal antibodies. Th... | 05/07/2002 |
| 6271381 | Cocaine derivative, protein conjugate thereof, monoclonal antibody producing cell line, method for preparing the cell line and monoclonal antibody A method for preparing a cocaine-protein conjugate easily by using a cocaine derivative having a methoxy carbonyl group and benzoyl group. This conjugate is useful for the detection of cocaine or cocaine derivatives.... | 08/07/2001 |
| 6174723 | Cocaine derivative, protein conjugate thereof, monoclonal antibody producing cell line, method for preparing the cell line and monoclonal antibody A method for preparing a cocaine-protein conjugate easily by using a cocaine derivative having a methoxy carbonyl group and benzoyl group. This conjugate is useful for the detection of cocaine or cocaine derivatives. A monoclonal antibody, a monoclonal an... | 01/16/2001 |
| 6114508 | Cocaethylene immunogens and antibodies The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for production of antisera and monoclonal antibodies. The antise... | 09/05/2000 |
| 6077848 | Benzoylecgonine, ecgonine and ecgonidine derivatives The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tiss... | 06/20/2000 |
| 6054127 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 04/25/2000 |
| 5876727 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 03/02/1999 |
| 5840307 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation Hapten-carrier conjugates capable of eliciting anti hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Anti-hapten antibodies elicited compete with free hapten upon subsequent challenge of a vaccinated individual. Met... | 11/24/1998 |
| 5808074 | Benzoylecgonine conjugate diagnostic reagents A benzoylecgonine conjugate represented by the following formula: ##STR1## wherein, R is H or CH3 ; R' is --NH--NH--, --(NH)2 --CO--(CH2)n --CO--NH--NH--, or related linear chains wherein at least one (CH | 09/15/1998 |
| 5770738 | Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions The new compounds of formula A--O--CO--Z (I) (wherein A and Z are defined as explained in the specification) can be prepared by conventional methods; they are suitable as active substances for pharmaceutical compo... | 06/23/1998 |
| 5770180 | Bridge-substituted tropanes for methods of imaging and therapy Disclosed are bridge-substituted analogs of tropanes and benztropines as well as methods for: imaging of cocaine receptors; treatment of cocaine abuse; and imaging and treatment of Parkinson's disease.... | 06/23/1998 |
| 5763456 | Benzoylecgonine, ecgonine and ecgonidine derivatives The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tiss... | 06/09/1998 |
| 5663345 | Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular. disorders, joint disorders, connective tissue disorders, circula... | 09/02/1997 |
| 5654314 | Esters of bi- and tricyclic amino alcohols and their use in pharmaceutical compositions The new compounds of formula A--O--CO--Z (I) (wherein A and Z are defined as explained in the specification) can be prepared by conventional methods; they are suitable as active substances for pharmaceutical compo... | 08/05/1997 |
| 5583142 | Analgesic and nootropic drugs Compounds of general formula: ##STR1## where: Ar=phenyl or beta-naphtyl, or aromatic heterocyclic 6-membered ring containing one or two nitrogen atoms; R1 =one or more substituents of the Ar nucleus, preferably in para position, and select... | 12/10/1996 |
| 5559123 | Derivatives of benzoylecgonine, ecgonine and ecgonidine and methods for preparing and using same The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulat... | 09/24/1996 |
| 5525613 | Covalently coupled benzoylecgonine ecgonine and ecgonidine The present invention relates to a novel class of covalently coupled benzoylecgonine, ecgonine and ecgonidine derivatives that are useful for alleviating the symptoms of immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tiss... | 06/11/1996 |
| 5506359 | Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders Disclosed are benztropine and CFT analogs useful for imaging of cocaine receptors and treatment of cocaine abuse. Also disclosed are analogs useful for imaging and treatment of Parkinson's disease.... | 04/09/1996 |
| 5416092 | 3-azabicyclo[3.2.1]-oct-8-yl-terminated non-peptidyl -succinamidoacyl aminodiols as anti-hypertensive agents Non-peptidyl compounds characterized generally as -succinamidoacyl aminodiols having a 3-azabicyclo[3.2.1]-oct-8-yl-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.... | 05/16/1995 |
| 5395832 | Benzamide derivatives A benzamide derivative represented by the following formula: ##STR1## wherein R1 represents a hydrogen atom or a lower alkanoyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents a lower alkoxy grou... | 03/07/1995 |
| 5391742 | Intermediates for 2-piperidino-1-alkanols 2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula ##STR1## wherein Q is S or CH.dbd.CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y1 are taken together and are arylmethylene or aralkyl... | 02/21/1995 |
| 5376667 | Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties The present invention relates to a novel class of benzoylecgonine, ecgonine and ecgonidine derivatives which are useful for preventing and treating immunoregulatory disorders, neuromuscular disorders, joint disorders, connective tissue disorders, circulat... | 12/27/1994 |
| 5233042 | Cocaine derivatives Compounds are provided for the preparation of reagents, including labels which can be used in immunoassays of cocaine and cocaine metabolites. The compounds are derivatives of cocaine which are conjugated to antigenic proteins or polypeptides for the form... | 08/03/1993 |
| 5202270 | Cocaine and cocaine metabolites assay tracers, immunogens and antibodies The present invention is directed to a fluorescence polarization assay for benzoyl ecgonine and substituted benzoyl ecgonine compounds in biological fluids, and to a method of making reagents therefor. Specifically, tracers, immunogens and antibodies are ... | 04/13/1993 |
| 4983600 | Heterocyclic compounds useful as 5-HT3 antagonists Aroyl ureas and carbamic acid derivatives of formula A--CO--NHCW--Y--B and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including optionally substituted phenyl W is O or S Y is NH or S and B is a specified saturated azacyclic ring,... | 01/08/1991 |
| 4772695 | Process for the preparation of vinyl carbamates A process for the preparation of vinyl carbamates of formula I ##STR1## is described which comprises heating an -halogeno-carbamate of formula II ##STR2## in which X is a halogen atom at a temperature between 70° and 250° C. for a ... | 09/20/1988 |
| 4393069 | 8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof Compounds of the formula ##STR1## wherein Ar is ##STR2## R1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-... | 07/12/1983 |
