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| Number | Title | Issue Date |
| 6677365 | Antagonists of MCP-1 function and methods of use thereof Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these com... | 01/13/2004 |
| 6653296 | Antiretroviral enantiomeric nucleotide analogs Resolved enantiomers of the formula (IA) and (IB) ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.... | 11/25/2003 |
| 6653320 | Imidazopyridine derivatives The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exh... | 11/25/2003 |
| 6642230 | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders Corticotropin releasing factor (CRF) antagonists of formula (I): ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as wel... | 11/04/2003 |
| 6635641 | Amide compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use Amide compounds represented by the formula: ##STR1## wherein: R1 is a moiety represented by the formula ##STR2## where X is selected from the group consisting of CH2, O, S, and NH; and Y is selected from the group consisting... | 10/21/2003 |
| 6635273 | Methods of treating vascular diseases characterized by nitric oxide insufficiency The present invention provides methods of treating vascular diseases where nitric oxide insufficiency is a contributing factor by administering a therapeutically effective amount of at least one antioxidant, or a pharmaceutically acceptable salt thereof, ... | 10/21/2003 |
| 6632809 | Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: ##STR1## or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for tr... | 10/14/2003 |
| 6630588 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.... | 10/07/2003 |
| 6630487 | Treatment of insulin resistance with growth hormone secretagogues This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, ##STR1## where the variables are defined in the specification, or the stereoisomeric mixture... | 10/07/2003 |
| 6613776 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula V: ##STR1## wherein Z1 is N, CRa, or CH, and Z2 is N or CH, provided one of Z1 and ... | 09/02/2003 |
| 6610692 | Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein b is NY or O; c is CY2 or N; d is CY3... | 08/26/2003 |
| 6605611 | Base analogues Nucleoside analogues or base analogues having structure (I), where X=O or NH or S, Y=N or CHR6 or CR6, W=N or NR6 or CHR6 or CR6 or S, n=1 or 2; each R6 is independently H or O or alkyl or ... | 08/12/2003 |
| 6586430 | CCR5 modulators Compounds of Formula 1 [Region ]-[Region ଲ]-[Region γ]-[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treat... | 07/01/2003 |
| 6582351 | Imidazopyridinone derivatives and their use as phosphodiesterase inhibitors A compound (Ia): ##STR1## wherein the variables are defined in the specification, its prodrug or a pharmaceutically acceptable salt thereof useful in the treatment of angina, hypertension etc.... | 06/24/2003 |
| 6573274 | Sulfonamide compounds and uses thereof as medicines The present invention relates to a sulfonamide compound of the formula (I): ##STR1## wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the ... | 06/03/2003 |
| 6559167 | Prodrugs of proton pump inhibitors Prodrugs of the pyridyl methyl sulfinyl benzimidazole type proton pump inhibitor drugs have a hydrolyzable arylsulfonyl or heteroarylsulfonyl group attached to the benzimidazole nitrogen. The prodrugs of the invention hydrolyze under physiological conditi... | 05/06/2003 |
| 6555539 | Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modula... | 04/29/2003 |
| 6552192 | Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof Various substituted nitrogen heterocyclic derivatives and their pharmaceutically acceptable salt derivatives are provided for use as medicaments, and particularly, as antimitotic, anti-viral, anti-cancer, anti-degenerative, immunosuppressive, and anti-mic... | 04/22/2003 |
| 6552037 | 2-Substituted imidazo[1,2-A]pyridine derivatives Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X, A, B, C, D and W are defined herein, which compounds bind with high selectivity and high affinity to the benzodiazepine s... | 04/22/2003 |
| 6545015 | Catechols as antimicrobial agents Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: ##STR1## wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino... | 04/08/2003 |
| 6545016 | Amide substituted imidazopyridines Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a var... | 04/08/2003 |
| 6545017 | Urea substituted imidazopyridines Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatme... | 04/08/2003 |
| 6541486 | Bis-benzimidazole compounds and analogs thereof for inhibiting cell death Compounds, pharmaceutical compositions, and methods of use are described which are effective in inhibiting cell death, particularly apoptotic cell death. The compositions may be used for prevention and treatment of injuries associated with cell death, inc... | 04/01/2003 |
| 6541482 | Carbocyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines The present invention relates to compounds of the formula ##STR1## wherein X is N3, NH2, NHR, N(R)2, CN, SH, SR, or OR1 ; R is C1 -C4 alkyl or (CH2)n --$c;; n is an inte... | 04/01/2003 |
| 6537994 | Heterocyclic 댣 adrenergic receptor agonists This invention provides compounds of Formula I having the structure ##STR1## wherein, ##STR2## U, V, and W are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related t... | 03/25/2003 |
| 6534521 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists The present invention relates to novel compounds and medical methods of treatment of inflammation, atherosclerosis, restenosis, and immune disorders especially those associated with lymphocyte or monocyte accumulation such as arthritis and transplant reje... | 03/18/2003 |
| 6525064 | Sulfonamido substituted imidazopyridines Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of... | 02/25/2003 |
| 6525056 | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders Corticotropin releasing factor (CRF) antagonists of Formula (I): ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as wel... | 02/25/2003 |
| 6521636 | Imidazo-pyridines as corticotropin releasing factor antagonists The present invention describes novel imidazo-pyridines of formula I: ##STR1## wherein D is aryl or heteroaryl or pharmaceutically acceptable salt forms thereof, which are useful as corticotropin releasing factor antagonists.... | 02/18/2003 |
| 6518281 | Immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.... | 02/11/2003 |
| 6515023 | Thrombin receptor antagonists A thrombin receptor antagonist having the formula ##STR1## useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non... | 02/04/2003 |
| 6495561 | 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists 4-substituted cyclohexanes substituted in the 1-position with imidazopyridine either directly or through a C1 -C4 alkyl, C1 -C4 alkenyl, C1 -C4 alkynyl, C1 -C4 alkoxy,... | 12/17/2002 |
| 6492384 | Imidazo (4,5-C) pyridine-4-one derivatives with factor XA inhibiting effect ##STR1## The invention relates to novel compounds of formula (I), wherein R, R1, R2, R3, n and p have the meaning defined in claim 1. Compounds are inhibitors of clotting factor Xa and can be used for the prophylaxis and/o... | 12/10/2002 |
| 6489338 | Imidazopyridine and imidazopyrimidine antiviral agents The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides imidazopyridine and imidazopyrimidine derivatives (Formula I) ... | 12/03/2002 |
| 6479508 | Viral polymerase inhibitors A compound of the formula I: ##STR1## wherein: X is CH or N; Y is O or S; Z is OH, NH2, NMeR3, NHR3 ; OR3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said heterocycle bei... | 11/12/2002 |
| 6476045 | Azaindole derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein: Het represents a heterocyclic residue selected from: ##STR2## where the dotted line in (b) represents an optional double bond; A completes a fused pyridine ring; and B completes a... | 11/05/2002 |
| 6476041 | 1,4 substituted piperidinyl NMDA/NR2B antagonists Novel piperidinyl compounds substituted in the 1- and 4-positions are effective as NMDA NR2B antagonists useful for relieving pain.... | 11/05/2002 |
| 6472403 | V integrin receptor antagonists The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors ... | 10/29/2002 |
| 6465484 | Angiogenesis inhibitors The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tryrosine kinase-dependent diseases/conditions such ... | 10/15/2002 |
| 6461747 | Heterocyclic compounds, materials for light emitting devices and light emitting devices using the same Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L.paren open-st.A)m... | 10/08/2002 |
