Class 546/108 - Phenanthridines (including hydrogenated)

Subclass of Class 546 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the tricyclo ring system has the following
No. of patents: 124
Last issue date: 10/28/2008

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Number	Title	Issue Date
7442790	Caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and...	10/28/2008
7378427	Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R1...	05/27/2008
7351807	Cyanine-sulfenates for dual phototherapy Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080 where E is selected from the group consisting of somatostatin receptor binding molecules, heat se...	04/01/2008
7304073	Method of treating myocardial ischemia-reperfusion injury using NF-kB inhibitors The present invention concerns a method of treatment or prevention of myocardial ischemia-reperfusion injury by diagnosing that a person is in need of treatment or prevention of myocardial ischemia-reperfusion injury and administering a therapeutically effective amo...	12/04/2007
7276606	Phenantridine analogues and uses thereof The present invention relates to compounds of the general formula (IV) and (II) and salts and physiologically functional derivatives thereof, wherein X is C—R8	10/02/2007
7145011	Method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids The invention relates to a method for the production of substituted 1,2,3,4-tetrahydroquinoline-2-carboxylic acids, i.e. 7,9-dichlor-3a,4,5,9b-tetrahydro-3H-cyclopental[c]quinoline-4-carboxylic acid. ...	12/05/2006
7122671	Luminescent labelling materials and procedures A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitat...	10/17/2006
7083986	Near infrared chemiluminescent acridinium compounds and uses thereof A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target analyte and binding the target analyte in the sample to a binding partner c...	08/01/2006
7067667	Aminoalkyl-3, 4-dihydroquinoline derivatives as no-synthase inhibitors 3,4-dihydroquinoline derivatives, a process for their production and their use in pharmaceutical agents. ...	06/27/2006
7037919	Tetrahydroquinoline derivatives Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical compositions containing the derivatives or the salts.	05/02/2006
6989446	Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V wherein ...	01/24/2006
6958347	Aminophenanthridinone and aminophenanthridine as NPY-5 antagonists The present invention provides NPY-5 receptor antagonists having a Formula (I) Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by the above NPY-5 receptor ant...	10/25/2005
6894061	Substituted dihydrophenanthridinesulfonamides This invention provides a compound of formulae (I) or (II) having the structure or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particu...	05/17/2005
6770668	Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthr...	08/03/2004
6723733	Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP. ...	04/20/2004
6608066	Tissue factor antagonists and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treating or prophylaxis of undesi...	08/19/2003
6573379	Method for preparing halomethyl heterocyclic compounds The present invention relates to a method for preparing 5- and 6-halomethyl quinoxalines. The method comprises contacting a 5- or 6-methyl quinoxaline with a halogenating agent in the presence of a radical initiator in a solvent selected from the group co...	06/03/2003
6562972	Method for preparing heterocyclic-carboxylic acids The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous alkaline suspension of a 5- or 6-halomethyl quinoxaline with oxygen in the presence of a transition metal catalyst, t...	05/13/2003
6538005	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics. ##STR1##...	03/25/2003
6534519	Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	03/18/2003
6534518	Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	03/18/2003
6534135	Process of preparing discotic liquid crystalline compounds The invention relates to a process of preparing a discotic liquid crystalline compound by intramolecular oxidative cyclisation of a diaryl compound in an organic solvent in the presence of a strong acid, characterized in that an oxidative agent comprising...	03/18/2003
6514988	Condensed-ring thiophene derivatives, their production and use A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or...	02/04/2003
6492517	Method for preparing halomethyl heterocyclic compounds The present invention relates to a method for preparing 5- and 6-halomethyl quinoxalines. The method comprises contacting a 5- or 6-methyl quinoxaline with a halogenating agent in the presence of a radical initiator in a solvent selected from the group co...	12/10/2002
6479505	6-arylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and Ar have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##...	11/12/2002
6476025	Phenylphennanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51, R6, R13 and R20 have the meaning indicated in the description, are novel active bronchial therapeutics ##STR1##...	11/05/2002
6476048	Substituted phenanthridinones and methods of use thereof This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, prodrug, or mixture thereof are also describe...	11/05/2002
6458950	Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen,...	10/01/2002
6417358	Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim 1, with carbon monoxide in the ...	07/09/2002
6248884	Extended rhodamine compounds useful as fluorescent labels Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure ##STR1## are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure ##STR2## I...	06/19/2001
6214839	Substituted 6-alkylphenanthridines Compounds of formula I ##STR1## pharmaceutically acceptable salts thereof and compositions of either are useful for treating conditions amenable to treatment with a phosphodiesterase inhibitor type 4....	04/10/2001
6187788	Condensed-ring thiophene derivatives, their production and use A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or...	02/13/2001
6147088	Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) and pharmaceutical acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions. ##STR1##...	11/14/2000
6127378	Phenanthridines substituted in the 6 position Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics....	10/03/2000
6120703	Derivatives of 6-fluorophenanthridine for liquid crystal mixtures 5-Fluorophenanthridine derivatives and their use in liquid-crystalline mixtures 6-Fluorophenanthridine derivatives of the formula (I) ##STR1## in which G is --CF.dbd.N--, E1, E2, E3, E4, E5 and E...	09/19/2000
6071929	Octahydro phenanthridine derivatives useful as NMDA-R receptor subtype blockers The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula: ##STR1## wherein: A is aryl R1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R--CO-- or R--COO--, wherein R is lower alkyl; R2	06/06/2000
6054448	2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' ...	04/25/2000
6015902	Intercalators having affinity for DNA and methods of use Intercalator compounds of formula I-Tm as defined herein are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high ...	01/18/2000
5925527	Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries The present invention relates to novel tricyclic tetrahydroquinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries composed of such compounds: ##STR1## wherein R	07/20/1999
5919928	Phenanthridine derivatives and metal complexes thereof used for transparent recording medium or optical recording medium A phenanthridine derivative metal complex of formula 1 having a large absorption in the near-infrared range and a reduced absorption in the visible range, which phenanthridine derivative metal complex is used in a transparent recording medium: ##STR1...	07/06/1999

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Class 546/108 - Phenanthridines (including hydrogenated)