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| Number | Title | Issue Date |
| 7465798 | Methods and compositions for selectin inhibition The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders ... | 12/16/2008 |
| 7423046 | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors Compounds of formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meaning indicated in the description, are novel effective PDE4 inhibitors. ... | 09/09/2008 |
| 7361796 | Orangic electroluminescence device A compound having a diphenylanthracene structure at the center and a specific structure substituted with an aryl group at end portions. An organic electroluminescence device comprises a plurality of layers of thin films of organic compounds which comprise a light em... | 04/22/2008 |
| 7335757 | Carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in p... | 02/26/2008 |
| 7276298 | Substance for intermediate layer of organic electroluminescent device and organic electroluminescent device using the same The present invention is related to an intermediate layer of an organic electroluminescent device comprising an amine derivative substance which may further comprise a functional group capable of forming crosslinks. In particular, the substance may have excellent so... | 10/02/2007 |
| 7129093 | Quantitative method of determining beryllium or a compound thereof in a sample A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluor... | 10/31/2006 |
| 7067261 | Methods and compositions for treatment of central nervous system disorders The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). ... | 06/27/2006 |
| 7038056 | Method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate A method for preparing a 7-quinolynyl-3,5-dihydroxyhept-6-enoate useful as an intermediate for pharmaceuticals, in high yield and in high purity, is presented. It is a method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate represented by the formula (IV): | 05/02/2006 |
| 7018840 | Fluorescent metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescent metal sensors for detecting metal ions, and methods of making and using the same. ... | 03/28/2006 |
| 6998405 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use Compounds of the general formula I wherein rings B, C, D and E may be present or not and, when present, are combined with A as A+C, A+E, A+B+C, A+B+D, A+B+E, A+C+E, A+B+C+D or A+B+C+D+E, rings B, C and E being aliphatic... | 02/14/2006 |
| 6995262 | Use of acylsulfonamido-substituted polymethine dyes as fluorescene dyes and/or markers The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I) in which n, Y, A and R have the meaning given in the claims, and at least one compound of the formulae ... | 02/07/2006 |
| 6960586 | Imidazole derivatives, process for their preparation and their use The present invention provides a compound having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism and tumor such as breast cancer and the like. A compound represented by the formula: ... | 11/01/2005 |
| 6955856 | Biphenyl derivatives and organic electroluminescent device employing the same A biphenyl derivative having an amino group with or without alkoxy substituent in the biphenyl backbone, and an organic electroluminescent device using the same. ... | 10/18/2005 |
| 6953791 | Dipeptide derivatives This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which inc... | 10/11/2005 |
| 6924372 | Benzopyrylo-polymethine-based hydrophilic markers The present invention relates to the field of optical-fluorescent markers, particularly to benzopyrylo-polymethine-based optical-fluorescent markers. ... | 08/02/2005 |
| 6849644 | Isoquinoline derivatives useful in the treatment of CNS disorders The invention relates to novel tetrahydroquinoline compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various CNS disorders. ... | 02/01/2005 |
| 6844344 | Benzofuran derivatives The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine ... | 01/18/2005 |
| 6835733 | Tropane linked benzofuran derivatives The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine. ... | 12/28/2004 |
| 6833455 | Bridged perinones/quinophthalones Disclosed herein are bridged perinones/quinophthalones of the general formula (I) or tautomeric forms thereof where X1, X2, Ar1 Ar2 and B are as described herein and are particularly characterized... | 12/21/2004 |
| 6830836 | Heterocyclic compounds, materials for light emitting devices and light emitting devices using the same Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): LA)m (I) | 12/14/2004 |
| 6727098 | Biaryl-type compounds, CD color fixing agent and method for determination of absolute configuration A novel achiral biaryl-type compound and a circular dichroism (CD) color fixing agent are provided. Furthermore, a method for determining an absolute configuration of a chiral compound is carried out by introducing the above achiral biaryl-type compound into the chi... | 04/27/2004 |
| 6683087 | Phenylethylamines and condensed rings variants as prodrugs of catecholamines, and their use Compounds of the general formula I ##STR1## and salts thereof with pharmaceutically acceptable acids or bases are disclosed as well as the use of such compounds for the manufacturing of pharmaceutical compositions for the treatment of Parkinson's dise... | 01/27/2004 |
| 6673625 | Saccharide sensing molecules having enhanced fluorescent properties The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wav... | 01/06/2004 |
| 6646149 | Polyamine analogues as therapeutic and diagnostic agents Novel "bispolyamine" inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cance... | 11/11/2003 |
| 6638929 | Tricyclic protein kinase inhibitors This invention provides compounds of formula 1, having the structure ##STR1## which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.... | 10/28/2003 |
| 6635759 | Luminescent 4-trifluoromethyl 1-2-quinolones with long wave UV absorption and the use thereof The invention relates to a substituted 4-trifluoromethyl carbostyril according to formula (I) and is characterised in that the 4-trifluoromethyl carbostyril is provided with an absorption maximum between 350 and 420 nm and a luminescence maximum between 4... | 10/21/2003 |
| 6620821 | HMG-CoA reductase inhibitors and method Compounds of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlip... | 09/16/2003 |
| 6608066 | Tissue factor antagonists and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treating or prophylaxis of undesi... | 08/19/2003 |
| 6579883 | Fluorinated 3,4-dihydroquinoline derivatives used as NOS inhibitors The invention relates to compounds of formula (I), to a method for producing them and to their use in medicaments as NOS inhibitors. ##STR1##... | 06/17/2003 |
| 6552032 | Opiate compounds, methods of making and methods of use The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.... | 04/22/2003 |
| 6538005 | Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, arm novel active bronchial therapeutics. ##STR1##... | 03/25/2003 |
| 6534135 | Process of preparing discotic liquid crystalline compounds The invention relates to a process of preparing a discotic liquid crystalline compound by intramolecular oxidative cyclisation of a diaryl compound in an organic solvent in the presence of a strong acid, characterized in that an oxidative agent comprising... | 03/18/2003 |
| 6534518 | Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity Compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##... | 03/18/2003 |
| 6534519 | Phenanthridine-N-oxides with PDE-IV inhibiting activity The N-oxides of the compounds of formula (I), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel active bronchial therapeutics. ##STR1##... | 03/18/2003 |
| 6492380 | Method of inhibiting neurotrophin-receptor binding The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor ... | 12/10/2002 |
| 6410551 | Tetrazole derivatives Compounds of formula I, ##STR1## in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are efficacious bronchial therapeutics.... | 06/25/2002 |
| 6391887 | 3,4-Dihydroquinoline derivatives as nitrogen monoxide synthase (NOS) inhibitors The invention relates to compounds of formula (I), as defined herein. The invention also relates to the use of the inventive compounds for treatment of a disease caused by the effects of nitrogen monoxide in pathological conditions. ##STR1##... | 05/21/2002 |
| 6383666 | Organometallic complex and organic electroluminescent device using the same Disclosed are new organometallic complex molecules having light-emitting and electron-transporting characteristics. Also disclosed is organic EL (electroluminescent) devices using these organometallic complex molecules as electron-transporting materials. ... | 05/07/2002 |
| 6355650 | (3R,4R)-Ɗ8-tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)-Ɗ8 -tetrahydrocannabi... | 03/12/2002 |
| 6310208 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines Since the compounds in accordance with the invention can bind to serotonin receptors (5HT2), they are especially suitable for the treatment or prevention of central nervous disorders such as depressions, bipolar disorders, anxiety states, sleep... | 10/30/2001 |
