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| Number | Title | Issue Date |
| 7331350 | Photochemical tissue bonding Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair. ... | 02/19/2008 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7077839 | Methods for tissue welding using laser-activated protein solders Various tissue glues have drawback such as toxicity, causing inflammatory reactions or insufficient bonding strength. The present invention is directed to methods of form tissue adhesion by administering to tissues compositions comprising proteins conjugated to one ... | 07/18/2006 |
| 6989390 | Amonafide salts Disclosed is a salt of amonafide or amonafide analogs represented Structural Formula (I): R1 is —(CH2)nN+HR3R4 X− or R1 is —(CH2) | 01/24/2006 |
| 6890377 | Thermochromic rylene dyes Rylene dyes of the general formula I where R is hydrogen; unsubstituted or substituted C1-C30-alkyl, aryl or hetaryl; R′ is unsubstituted or substituted C2-C... | 05/10/2005 |
| 6768010 | Organophotoreceptor with an epoxy-modified charge transport compound having an azine group Organophotoreceptors comprise an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: a) a charge transport compound having the formula | 07/27/2004 |
| 6693198 | Amonafide salts Disclosed is a salt of amonafide or amonafide analogs represented Structural Formula (I): ##STR1## R1 is --(CH2)n N+ HR3R4 X- or R1 is --(CH2)n N+ HR3R4 X- or --(C... | 02/17/2004 |
| 6559306 | Dye compounds This invention relates to new fluorescent or non-fluorescent dye compounds having a terminal hydroxy, carboxylic acid/ester or amino group and a process for their preparation. The new fluorescent or non-fluorescent dye compounds are useful as colorants fo... | 05/06/2003 |
| 6486319 | Thermochromic rylene dyes The invention relates to rylene dyes of the general formula (I), wherein the variables have the following meanings: R represents hydrogen; optionally substituted C1 -C30 alkyl-C5 -C8 -cycloalkyl, aryl or hetaryl... | 11/26/2002 |
| 6410505 | Dimeric non-azo naphthalimides and uses for the same A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino... | 06/25/2002 |
| 6358746 | Fluorescent compounds for use in industrial water systems Fluorescent compounds of the formula: ##STR1## wherein R1 and R2 are either both SO3 M, or one of R1 and R2 is SO3 M and the other is COOM, where M is selected from the group consisting of ... | 03/19/2002 |
| 6248890 | Naphthalimide diester fluorescent tracers having improved solubility and fluorescence A fluorescent naphthalimide diester dye that is miscible or soluble in a variety of organic compounds such as, for example, mineral oil, polyalkylene glycols, polyolesters, motor oil, gear oil, synthetic oils, and polyalphaolefins, is provided. The fluore... | 06/19/2001 |
| 6177570 | Method for producing aromatic bisimides Bisimides of the formula I ##STR1## where R1, R2, R3 and R4 have the meanings stated in the description, are prepared in a process in which the corresponding dicarboxylic anhydrides of the formulae II and III R | 01/23/2001 |
| 6150306 | Fluorescent tracer dyes A dye composition has the formula: ##STR1## where R1 and R2 are the same or different and are selected from (A) C2 -C12 alkyloxyalkyl, and (B) C9-12 alkyl, (A) comprising from about 30 to 80 mole... | 11/21/2000 |
| 6133259 | Alkyl, alkenyl and alkynyl chrysamine G derivatives for inhibition of cell degeneration and toxicity associated with amyloid deposition Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloido... | 10/17/2000 |
| 5998621 | Aryloxy-poly(oxyalkylene) naphthalimide derivative colorants This invention relates to colorants comprising naphthalimide base groups with specific water-solubilizing pendant moieties attached. These pendant moieties are based upon aryloxypolyoxyalkylene groups which provide the desired solubility to the naphthalim... | 12/07/1999 |
| 5981753 | Bis-naphthalimides for the treatment of cancer Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula ##STR1## wherein X, X', X" and X'", A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutica... | 11/09/1999 |
| 5917045 | Dimeric non-azo naphthalimides and uses for same A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino... | 06/29/1999 |
| 5918269 | Naphthalimide colorants with improved compatibility in refrigeration and air conditioning lubricants Novel naphthalimide-derivative colorants are provided which are present in a neat liquid state at ambient temperature and pressure. Such colorants are produced through the reaction between 4-chloro (or bromo)-1,8 naphthalic anhydride and at least one ethe... | 06/29/1999 |
| 5858930 | Liquid Benz-iso-Quinoline derivatives 1,8-Naphthalimide derivatives of Formula (I) are useful as fluorescent dyes: ##STR1## wherein R1 and R2 are each independently selected from the group consisting of branched alkyl groups containing 7-8 carbon atoms and alky... | 01/12/1999 |
| 5840903 | 4-aminomethyl-1-azaadamantane derived benzamides This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein Z is selected from the group consisting of ##STR2## R1 is alkoxy of one to six carbon atoms; R2, R3 | 11/24/1998 |
| 5817820 | Quinolone derivatives and processes for the preparation thereof The present invention relates to optical isomers of quinoline compounds of Formula (IA) or Formula (IA'), their pharmaceutically acceptable salts and their intermediates: ##STR1## In the above formulae, A represent nitrogen or ##STR2## in w... | 10/06/1998 |
| 5776963 | 3-(heteroaryl)-1-(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 07/07/1998 |
| 5663449 | Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 09/02/1997 |
| 5654319 | N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 08/05/1997 |
| 5641782 | 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides This invention relates to 3-Pyrimidinyl Bisnaphthalimides as Anticancer Agents and pharmaceutically acceptable salts thereof, of the formula: ##STR1## and processes for the preparation of such compounds, pharmaceutical composition containing such com... | 06/24/1997 |
| 5639764 | 2-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,3-indandiones and related compound and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 06/17/1997 |
| 5637710 | Intermediate compounds in the synthesis of heteroarylpiperidines and piperazines Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 06/10/1997 |
| 5614543 | 1-(aryloxyalkyl)-3- (heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 03/25/1997 |
| 5612343 | N-[(4-heteroaryl-1-piperazinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 03/18/1997 |
| 5599821 | 4-heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 02/04/1997 |
| 5597842 | 3-heteroaryl-1-pyrrolidinealkanols and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 01/28/1997 |
| 5585497 | Substituted 1-naphthyl-3-pyrazolecarboxamides which are active on neurotensin The invention relates to substituted 1-naphyl-3-pyrazolecarboxamides of formula I: ##STR1## These compounds are useful for the treatment of neuropsychiatric disorders, especially those associated with a dysfunction of the dopaminergic systems.... | 12/17/1996 |
| 5580890 | Heteroarylpyrrolidines and their use as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 12/03/1996 |
| 5578624 | Heteroarylpyrrolidines and their use as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 11/26/1996 |
| 5571803 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 11/05/1996 |
| 5552544 | 5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and their use An antitumor 5-nitrobenzo[de]isoquinoline-1,3-dione of the formula I ##STR1## where n is 1 or 2, R1 and R2 are identical or different and are each hydrogen, C1 -C6 -alkyl, C1 -C6 -hydroxyal... | 09/03/1996 |
| 5502059 | Substituted 1-naphthyl-3-pyrazolecarboxamides which are active on neurotensin, their preparation and pharmaceutical compositions containing them The invention relates to substituted 1-naphthyl-3-pyrazolecarboxamides of formula I: ##STR1## Application: These compounds are useful for the treatment of neuropsychiatric disorders, especially those associated with a dysfunction of the dopamine... | 03/26/1996 |
| 5488110 | Highly water soluble bis-naphthalimides useful as anticancer agents This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis(methylimino-2,1-ethanediyl)]-bis[5-nitro-1H-benz[d e]isoquinoline-1,3(2H)-dione], 2-[2-[N-methyl-N-[2-[[2-(5-nitro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-y l)ethyl]amino]e... | 01/30/1996 |
| 5420136 | Eradication of pathogenic biological contaminants using non-azo naphthalimide dyes A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being chara... | 05/30/1995 |
