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| Number | Title | Issue Date |
| 7390812 | N, N'-disubstituted piperazine compounds and their use as analgesics N,N′-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N′-disubstituted piperazine compounds for the production of pharmaceutical preparations and in related methods... | 06/24/2008 |
| 7196033 | Advances in amination catalysis Provided herein are catalysts useful in reductive amination, which include nickel, copper, zirconium and/or chromium, oxygen, and tin. The presence of the tin increases the selectivity of the catalyst in reductive aminations over the catalysts of the prior art. ... | 03/27/2007 |
| 7078475 | Synergistic amine chain-extenders in polyurea spray elastomers Disclosed are derivatives of isophorone diamine exhibiting a synergistic relationship with other commonly employed chain extenders offering enhanced efficacy with regard to slowing of the polyurea elastomer cure profile, and processes employing their use. According ... | 07/18/2006 |
| 7078407 | 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them The present invention relates to 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them. More particularly, it relates to 4-hydroxycinnamamide derivatives showing superior antioxidant activity compared to the known antioxida... | 07/18/2006 |
| 6887872 | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suit... | 05/03/2005 |
| 6881738 | Analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as amyotrophic lateral sclerosi... | 04/19/2005 |
| 6875759 | Substituted guanidines and the use thereof A method for the treatment of cancer and pain in an animal subject is disclosed, comprising administering to said animal in need of such treatment an effective amount of a compound of formula I: wherein R1-R... | 04/05/2005 |
| 6776911 | Methods for surface modification of silica for use in capillary zone electrophoresis and chromatography The present invention refers to the use of novel molecules able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When applied to silica-based chromatography, it offers important advantages in... | 08/17/2004 |
| 6734177 | Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said salts. ... | 05/11/2004 |
| 6703425 | Sulfonamide derivatives The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders ##STR1##... | 03/09/2004 |
| 6579881 | Indoles A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3 | 06/17/2003 |
| 6448243 | 1,4-substituted cyclic amine derivatives A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R1, R2, R3, ... | 09/10/2002 |
| 6281393 | Polyols useful for preparing water blown rigid polyurethane foam Mannich polyols having a viscosity of from 300 to 3,500 cps (0.3 to 3.5 Pa*s) at 25° C. are prepared by admixing a phenol, an alkanolamines, and formaldehyde mixed in molar ratios of from 1:1:1 to 1:2.2:2.2 resulting in an initiator which can be alkoxyla... | 08/28/2001 |
| 6013801 | Method for producing aminoethylethanolamine and/or hydroxyethyl piperazine A method for preparing aminoethylethanolamine, and/or hydroxyethylpiperazine is described. Reaction of ethylene oxide with ethylendiamine, piperazine, or a mixture of both produces these compounds. The process is integrated into a distillation plant for p... | 01/11/2000 |
| 5945393 | Nonionic gemini surfactants Novel nonionic gemini surfactants are extremely effective emulsifiers for oil-in-water emulsions that provide improved detergency at even low concentration levels. The surfactants are characterized by the formula: ##STR1## wherein R1 is in... | 08/31/1999 |
| 5874436 | Triphenylalkyl antimicrobial agents The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the acti... | 02/23/1999 |
| 5872117 | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebro... | 02/16/1999 |
| 5856331 | Method for preventing tissue injury from hypoxia There is disclosed a method for preventing tissue injury caused by tissue hypoxia and reoxygenation, comprising administering a compound that inhibits signal transduction by inhibiting cellular accumulation of linoleoyl phosphatidic acid (PA) through an i... | 01/05/1999 |
| 5808160 | Preparation of hydroxy-alkyl-substituted aminoalkynes with heterogenous catalysis Hydroxyalkyl-substituted aminoalkynes of the general formula I ##STR1## where at least one of the substituents R1, R4 or R5 is hydroxyalkyl are prepared in a reaction with heterogeneous catalysis.... | 09/15/1998 |
| 5807855 | 1-piperazino-1,2-dihydroindene derivatives Trans isomers of 1-piperazino-1,2-dihydroindene compounds having formula (I), ##STR1## wherein X and Y are hydrogen, halogen, trifluoromethyl, alkyl, alkylthio, trifluoromethylthio, alkoxy, hydroxy, alkylsulfonyl, amino, alkylamino, nitro or cya... | 09/15/1998 |
| 5801175 | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system.... | 09/01/1998 |
| 5773617 | Deallylation reagent and deallylation method using said reagent The present invention relates to a reagent and to a process which are useful, when carrying out an organic synthesis, for cleaving an allylic group from a function which is protected with the latter. This reagent is defined in that it contains: a) a solvent sy... | 06/30/1998 |
| 5641783 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 06/24/1997 |
| 5604229 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 02/18/1997 |
| 5563271 | N-(2-sulfatoethyl)piperazine sulfate and its preparation Preparation of N-(2-sulfatoethyl)piperazine sulfate by reacting N-(2-hydroxyethyl)piperazine in a mixture of high- or relatively high-percentage sulfuric acid and oleum or chlorosulfonic acid at temperatures of about 80° C. to about 250° C., introducing... | 10/08/1996 |
| 5554793 | Catalytic reforming of alkyleneamines A process of reforming an alkyleneamine feedstock or a mixture of such feedstocks to an alkyleneamine or a mixture of alkyleneamines which is different from the feedstock or feedstock mixture. The process is catalyzed by one of the following: Group VB met... | 09/10/1996 |
| 5492913 | N-benzylpiperazine compounds The compounds are N-(unsubstituted or substituted) N'-benzylpiperazine compounds and pharmaceutically tolerable salts thereof, useful for treating neuronal disorders resulting from the dysfunctioning of oxidative metabolism. A compound disclosed is: N-eth... | 02/20/1996 |
| 5491263 | Aminoethylation process for production of substituted ethylene diamines A process is disclosed for producing a substituted ethylenediamine, the process comprising reacting an oxazolidinone with a secondary amine or an alkanolamine. The process includes, in one aspect, reacting precursors of the oxazolidinone in situ.... | 02/13/1996 |
| 5476969 | Highly reactive polyoxyalkylene-polyols containing tertiary amino groups in bonded form, their preparation, and their use for the preparation of polyisocyanate polyaddition products The invention relates to highly reactive polyoxyalkylene-polyols prepared by oxyalkylation of an initiator molecule containing, in bonded form, at least 2 reactive hydrogen atoms and at least one tertiary amino group bonded via a spacer bridge, which pref... | 12/19/1995 |
| 5472984 | 1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebro... | 12/05/1995 |
| 5464941 | Biphenyl pyrazine compounds The present invention provides novel substituted biphenyl pyrazines or pyrazine derivatives ("BPD") which are functional and have useful application as a monomer for a variety of high performance polymers such as polyester, polyarylate, polycarbonate, pol... | 11/07/1995 |
| 5455352 | Preparation of N-(2-hydroxyethyl)-piperazine Preparation of N-(2-hydroxyethyl)-piperazine by reacting triethanolamine with ammonia in the presence of hydrogen at from 100° to 500° C. and from 10 to 500 bar over a heterogeneous catalyst in which the catalytically active material contains from 20 to... | 10/03/1995 |
| 5410086 | Selective preparation of diethylenetriamine This invention relates to a method for controlling the weight ratio of diethylenetriamine to piperazine in a process in which ethylenediamine, or a mixture of ethylenediamine and monoethanolamine, and hydrogen are maintained in the presence of a hydrogena... | 04/25/1995 |
| 5410087 | Catalytic reforming of alkyleneamines A process of reforming an alkyleneamine feedstock or a mixture of such feedstocks to an alkyleneamine or a mixture of alkyleneamines which is different from the feedstock or feedstock mixture. The process is catalyzed by one of the following: Group VB met... | 04/25/1995 |
| 5409931 | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and a... | 04/25/1995 |
| 5371088 | 1-aryl-4-piperazinylcyclohexanecarbonitriles, the preparation and use thereof Compounds of the formula ##STR1## where Ar, R1, R2, P and Q have the meanings indicated in the description, and the preparation thereof are described. The compounds have antihypoxic and antiischemic action and are suitable for t... | 12/06/1994 |
| 5367050 | Polyether polyol production of a flexible urethane foam and shaped article therefrom A polyether polyol produced by using an N-amino-ethylpiperazine-ethylene oxide aduct as an initiator and addition-polymerizing an alkylene oxide thereto and having a molecular weight of about 2000 to 7000; a process for producing a flexible urethane foam ... | 11/22/1994 |
| 5352677 | Cinnamamide derivative Cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide deri... | 10/04/1994 |
| 5326762 | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase Amides of the formula ##STR1## wherein R1 and R2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl; and in addition, one of R1 and R... | 07/05/1994 |
| 5292910 | Use of hydrophobized hydrotalcites as catalysts for ethoxylation or propoxylation A process for the catalyzed ethoxylation or propoxylation of compounds selected from the group consisting of organic compounds containing active H atoms, esters of fatty acids containing 2 to 22 carbon atoms with monoalkanols containing 1-22 carbon atoms ... | 03/08/1994 |
