Class 544/400 - Acyclic nitrogen bonded directly to the -C(=X)- group

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein acyclic nitrogen is bonded directly to
No. of patents: 299
Last issue date: 03/20/2012

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Number	Title	Issue Date
8138341	Intermediate compounds useful for the manufacture of dihydropteridinones Disclosed are processes and intermediate compounds for preparing dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and in the specification...	03/20/2012
7442692	Indanyl-piperazine compounds A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a be...	10/28/2008
7439358	Specific salt, anhydrous and crystalline form of a dihydropteridione derivative The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pt...	10/21/2008
7427632	Factor Xa inhibitors Compounds of formula (I) in which R1, n, Z, R3 and R4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment of ...	09/23/2008
7407959	Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s...	08/05/2008
7375134	Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s...	05/20/2008
7358395	Crystalline form V of agomelatine, a process for its preparation and pharmaceutical compositions containing it Crystalline form V of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful in the treatment of melatoninergic disorders. ...	04/15/2008
7358359	Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria...	04/15/2008
7351719	Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t...	04/01/2008
7304065	Melanin concentrating hormone antagonists The present invention relates to compounds capable of serving as moderators of human and mammalian appetite and as such provides a means for reducing body mass. The compounds of the present invention are selective against melanin concentrating hormone and do not hav...	12/04/2007
7282608	Inhibitors of histone deacetylase The invention provides compoods and methods for treating cell proliferative-diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, ...	10/16/2007
7232817	α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	06/19/2007
7227022	Use of 2-amino-thiazoline derivatives as inhibitors of inducible no-synthase The present invention relates to a process for preparing 2-amino-thiazoline derivatives of formula (II): in which either Y is a methylene (CH2) and X is chosen from the following groups: O, NH, (C1–C...	06/05/2007
7205303	Substituted heterocyclic compounds Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, m particular cardiovascular diseases such as atrial and ventricular arrhythmias, inter...	04/17/2007
7199158	Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,...	04/03/2007
7160887	Aromatic amine derivatives, their production and use Compounds of a formula: wherein Ring A represents an optionally-substituted aromatic ring; Ring B represents an optionally-substituted cyclic hydrocarbon group; Z represents an optionally-substituted cyclic group...	01/09/2007
7115610	Substituted heterocyclic compounds Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri...	10/03/2006
7105507	Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R	09/12/2006
7074820	Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like protease...	07/11/2006
RE39088	Amide compounds and use of the same An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 ...	05/02/2006
7030122	1,4-disubstituted piperazine ligands for neurotransmitter receptors One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including serotonin receptors and dopamine recepto...	04/18/2006
7026323	Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmace...	04/11/2006
6995269	Guanidinobenzamides Compounds of formula IIA and IIB are novel guanidine compounds where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and ...	02/07/2006
6992081	Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases. ...	01/31/2006
6964963	Preparation of 4-amino-1-naphthol ethers The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl g...	11/15/2005
6960588	Tryptase inhibitors Compounds of formula (I) in which M, B1, B2, B3, B4, B5, B6, A1, A2, A3, A4, A5, A6, K1 and K2 have the meanings as indicated in the description, are novel effective tryptase inhibitors. ...	11/01/2005
6906073	Piperazine CCR-3 receptor antagonists The invention provides compounds of Formula (I): wherein: R1-R4, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions co...	06/14/2005
6887876	Benzamidine derivatives Benzamidine derivatives are useful delta-opioid receptor modulators, agonists useful as analgesics and antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psy...	05/03/2005
6887903	N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them The compounds of formula 1 wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN ...	05/03/2005
6878707	Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion Compounds of formula (I) wherein R2—C, R3—C, R4—C or R5—C may be replaced by N; and wherein n is 1, 2 or 3; R1 is aryl, heteroaryl or (aryl or heteroaryl)-lo...	04/12/2005
6852723	Aralkyl substituted piperazine compounds Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to pr...	02/08/2005
6846824	Bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them Compounds of formula (I) its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates can be used to prevent or treat diabetes caused by ins...	01/25/2005
6844299	Polyol ester derivatives of polyamines and use in turbine oils to improve cleanliness This invention generally relates to new polyol ester derivatives of polyamines for use as dispersant additives compatible in synthetic ester-based turbo oils. The dispersant additives of the present invention consist of a hydrocarbon acid, a polyol, an amine carrier...	01/18/2005
6838460	Substituted phenylamidines medicaments containing said compounds and method for production thereof The present invention relates to phenylamidines of general formula wherein R6 and R7 are defined as in claim 1, the tautomers, the stereoisomers including...	01/04/2005
6770649	1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds, process for their preparation and pharmaceutical compositions containing them Novel 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]-piperazine compounds which are antagonistic to tachykinin receptors, of the general formula I, wherein R6, R7, A and Z have the meanings given in the...	08/03/2004
6753327	Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: ...	06/22/2004
6747027	Thiol sulfonamide metalloprotease inhibitors This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes ...	06/08/2004
6686360	N-benzylpiperazine compounds The present invention relates to a compound selected from those of formula (I): ##STR1## wherein: R1 represents alkyl, R2 represents hydroxy, alkoxy, or amino, n represents an integer from 1 to 12 inclusive, R3 represents: hydr...	02/03/2004
6677336	Substituted piperazine compounds Novel compounds of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subse...	01/13/2004
6638927	Guanidinobenzamides Compounds of formula IA and IB are new ##STR1## where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceut...	10/28/2003

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Class 544/400 - Acyclic nitrogen bonded directly to the -C(=X)- group