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| Number | Title | Issue Date |
| 7569691 | Protected piperazino group-bearing organoxysilane compound and making method A novel organoxysilane compound bearing a protected piperazino group is provided. It can impart rigidity, high mechanical strength, and transparency in the UV region when used in paints, adhesives and the like. ... | 08/04/2009 |
| 7442692 | Indanyl-piperazine compounds A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a be... | 10/28/2008 |
| 7378446 | Compound having anti-HCV activity and process for producing the same The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV,... | 05/27/2008 |
| 7368448 | 2-(arylalkoxy)-1-phenylethylamine derivatives as NKantagonist and serotonin reuptake inhibitors Compounds of the following formula (I) wherein R1 R2, n, Ar1 and A2 are as defined in the specification, in vivo-hydrolysable precursors thereof, pharmaceutically acceptable salts thereof, the use in therapy and pharmaceut... | 05/06/2008 |
| 7307169 | Isotopically enriched N-substituted piperazines and methods for the preparation thereof In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines. ... | 12/11/2007 |
| 7297697 | 4-(diarylmethyl)-1-piperazinyl derivatives A compound of formula I wherein X, Y, X′ & Y′ are selected from hydrogen, halogen, substituted or unsubstituted alkyl (linear, branched or cyclo), aryl, alkyloxy and haloalkyl group; R1, R2, R... | 11/20/2007 |
| 7285553 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 10/23/2007 |
| 7268140 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory... | 09/11/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7135473 | Cyclic diamine compound with condensed-ring groups A cyclic diamine compound of formula (1): wherein R1 and R2 are individually a hydrogen atom or a methoxy group, provided R1 is a methoxy group when R2 is a hydrogen at... | 11/14/2006 |
| 7122294 | Photoacid generators with perfluorinated multifunctional anions Photoacid generators (PAGs) comprising photoactive moieties and perfluorinated, multifunctional anionic moieties (or incipient anionic moieties) are disclosed which provide photoacids with high acid strength, low volatility and low diffusivity. The present invention... | 10/17/2006 |
| 7115610 | Substituted heterocyclic compounds Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri... | 10/03/2006 |
| 7074820 | Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like protease... | 07/11/2006 |
| 7056567 | Fiber-reinforced composite structure A fiber-reinforced composite structure has two molded outer polymeric layers spaced apart from each other and defining a cavity therebetween. Each molded outer polymeric layer defines a sealing surface extending about a periphery of the respective layer, and the opp... | 06/06/2006 |
| 7049306 | Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4. Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 05/23/2006 |
| 7019007 | CCR-3 receptor antagonists (I) The invention provides compounds of Formula (I): wherein: R1–R4, A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions c... | 03/28/2006 |
| 6919482 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 07/19/2005 |
| 6916797 | α-arylethylpiperazine derivatives as neurokinin antagonists The invention relates to new α-arylethylpiperazine of the formula wherein Z represents 0 or S; n′ represents 1 or 2; R2 represents a hy... | 07/12/2005 |
| 6906163 | Prepolymer catalysts suitable for preparing spandex fibers Segmented polyurethane/ureas useful for the production of spandex, particularly spandex fibers, are made from isocyanate-terminated prepolymers formed by reacting excess isocyanate with an isocyanate-reactive component satisfying specified compositional requirements... | 06/14/2005 |
| 6903179 | Polyurethane/ureas useful for the production of spandex and a process for their production Segmented polyurethane/ureas useful in the production of spandex are produced by chain extending an isocyanate-terminated prepolymer in the presence of a solvent. The isocyanate-terminated prepolymer is formed by reacting a stoichiometric excess of an isocyanate wit... | 06/07/2005 |
| 6900350 | Method for the production of ω-aminoalkylsulphonic acids The invention relates to a method for the production of ω-aminoalkylsulphonic acids of general formula (I), where R1 and R2=optionally substituted alkyl groups with 1 20 C atoms and n=a whole number from 2 6, whereby an amine of formula (II), where R1 and R2 have t... | 05/31/2005 |
| 6900243 | Phenylheteroalkylamine derivatives There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their pre... | 05/31/2005 |
| 6887885 | Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands A compound of formula I, or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 a... | 05/03/2005 |
| 6884803 | Phenylalkynes Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and us... | 04/26/2005 |
| 6846813 | Compounds to treat alzheimer's disease The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases. | 01/25/2005 |
| 6844366 | Sulfonamide hydroxamates This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds. ... | 01/18/2005 |
| 6747027 | Thiol sulfonamide metalloprotease inhibitors This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes ... | 06/08/2004 |
| 6706745 | Biphenylamidine derivatives The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically applicable FXa inhibitor.... | 03/16/2004 |
| 6703425 | Sulfonamide derivatives The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders ##STR1##... | 03/09/2004 |
| 6686353 | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists Cyclic diamines of formula (I) or their pharmacologically acceptable acid addition salts, and their medical applications are described. These compounds inhibit the action of chemokines such as MIP-1a and/or MCP-1 on target cells, and are useful as a thera... | 02/03/2004 |
| 6649616 | Substituted phenylcyclohexanecarboxamides and their use The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) ##STR1## to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.... | 11/18/2003 |
| 6608066 | Tissue factor antagonists and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treating or prophylaxis of undesi... | 08/19/2003 |
| 6579881 | Indoles A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3 | 06/17/2003 |
| 6569929 | Method to prepare phosphoramides, and resin compositions containing them The present invention relates to a method for preparing phosphoramides having a glass transition temperature in one embodiment of at least about 0° C., in another embodiment of at least about 10° C., and in still another embodiment of at least about 20Â... | 05/27/2003 |
| 6552025 | Diimino-piperazine derivatives for use as modulators of cell regulation Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(ω-aminobutyl)-3,5-diimino... | 04/22/2003 |
| 6541475 | , ଲ-unsaturated sulfones for treating proliferative disorders , ଲ-Unsaturated sulfones of the following formulae are provided, which are useful as antiproliferative agents, including, for example, anticancer agents: ##STR1##... | 04/01/2003 |
| 6525099 | N-substituted sulfonamide derivatives The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 02/25/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6489327 | Tryptase inhibitors The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.... | 12/03/2002 |
| 6479495 | Aminoalkylphenol derivatives and related compounds Novel aminoalkylphenols, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the aminoalkylphenols or compositions thereof are disclosed.... | 11/12/2002 |
