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| Number | Title | Issue Date |
| 7419980 | Fused-aryl and heteroaryl derivatives and methods of their use The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms... | 09/02/2008 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6706745 | Biphenylamidine derivatives The present invention relates to a biphenylamidine derivative of the general formula (1): or a pharmaceutically acceptable salt thereof, which is a novel compound functioning as a clinically applicable FXa inhibitor.... | 03/16/2004 |
| 6387389 | Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions comprising the same, and a method of using such sustained-r... | 05/14/2002 |
| 6214848 | Pharmaceutical composition Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for p... | 04/10/2001 |
| 6130222 | Compounds with analgesic effect Compounds of the formula (I) ##STR1## as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain.... | 10/10/2000 |
| 5962507 | O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R1 and R2 | 10/05/1999 |
| 5962479 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having formulae (I), (II) or (III) wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the description, a... | 10/05/1999 |
| 5919777 | Compounds with growth hormone releasing properties The present invention relates to novel compounds of the general formula I ##STR1## which can be used for treating medical disorders resulting from a deficiency in growth hormone.... | 07/06/1999 |
| 5840896 | Method of preventing or limiting reperfusion damage There is disclosed a process for preparing (l)-(-)-2-aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-5,5-bis(4-fluor ophenyl)pentyl!-1-piperazineacetamide which comprises the steps of (a) cyclizing (-)-(S,S)-N1,N2 -bis(1-phenylethyl... | 11/24/1998 |
| 5432179 | Piperazine derivatives and pharmaceuticals containing the same A piperazine derivative represented by the following formula: ##STR1## or a pharmaceutically acceptable salt thereof. The compound according to the present invention has strong anti-histaminic and anti-allergic affects and a high degree of safety, an... | 07/11/1995 |
| 5324728 | Naphthoic acid derivative A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group,... | 06/28/1994 |
| 5308840 | Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A i... | 05/03/1994 |
| 5276035 | 1,4-disubstituted piperazines A disubstituted piperazine compound having the formula ##STR1## wherein R1 is halogen, methoxy, C1-6 -alkyl or trifluoromethyl, and R2 is methyl or substituted C1-8 -alkyl, C3-8 -alkenyl or C | 01/04/1994 |
| 5066680 | Novel substituted-acetamide compound and a process for the preparation thereof Compounds of the formula ##STR1## wherein R1 is aryl which may have one or more suitable substituent(s), R2 is aryl which may have one or more suitable substituent(s), lower alkyl or cyclo(lower)alkyl, R3 is hydrogen,... | 11/19/1991 |
| 5036098 | Butynylamine derivatives and their production Compounds of the formula (I): ##STR1## exhibit anti-cholingeric and calcium antagonistic action and are used for treating pollakiuria and incontinence in humans and animals.... | 07/30/1991 |
| 5028610 | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use Compounds of formula (I): A--M--B-- (I) (in which: M represents a saturated heterocyclic group having from 5 to 7 ring atoms of which 2 are nitrogen atoms, said group being unsubstituted or being substituted at ... | 07/02/1991 |
| 5026853 | 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide der... | 06/25/1991 |
| 4968684 | Method of improving sleep A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide der... | 11/06/1990 |
| 4957941 | Anti-spasmdoic agents having an acetylenic bond A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where Y is H or OH; j is an integer from 0 to 4; k is an integer from 0 to 4, and wherein m is an integer from 1 to 4; n is an i... | 09/18/1990 |
| 4918073 | Diarylalkyl-substituted alkylamines and medicaments containing them A compound I ##STR1## in which R1 is cycloalkyl, alkenyl, cycloalkenyl, phenyl, ##STR2## where J, L, M, and E are methine or nitrogen and J', L', M', and E' are methylene, carbonyl or imino; R2 is phenyl or phenylalkyl; a i... | 04/17/1990 |
| 4908365 | Benzhydryloxyethylpiperazine derivatives, processes for their preparation and pharmaceutical compositions in which they are present The present invention relates to benzhydryloxyethylpiperazine derivatives of the formula: ##STR1## It also relates to processes for the preparation of the said derivatives and pharmaceutical compositions in which they are present. The said deriv... | 03/13/1990 |
| 4882331 | 1-[(1,1-diphenyl)-1-alkenyl]piperazine derivatives, method of preparation and pharmaceutical compositions in which they are present The invention relates to 1-[(1,1-diphenyl)-1-alkenyl]piperazine derivatives corresponding to general formula I: ##STR1## in which R1, R2, R3, R4 and R5, which are identical or different, represen... | 11/21/1989 |
| 4880808 | N-aryl-piperazinealkanamides useful for improving sleep A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide der... | 11/14/1989 |
| 4874765 | 1,4-Disubstituted piperazines having dopaminergic activity The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their prepar... | 10/17/1989 |
| 4868184 | Benzhydrylpiperazines pharmaceutical compositions thereof and method of use The invention relates to novel benzhydryl-piperazine derivatives of the general formula (I) and the acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formul... | 09/19/1989 |
| 4866062 | 1,4-disubstituted piperazines, pharmaceutical compositions thereof and method of use The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general fo... | 09/12/1989 |
| 4826844 | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols Compounds of the formula: ##STR1## in which m is one of the integers 1, 2 or 3; n is one of the integers 0, 1 or 2; o is one of the integers 0, 1 or 2; R1 and R2 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy... | 05/02/1989 |
| 4806685 | 1,1,2-triphenylpropane and -propene derivatives A novel 1,1,2-triphenylpropene derivative, namely: ##STR1## acts on the endocrine system of rats. It exerts oestrogenic or antioestrogenic effects of varying strength in rats, and furthermore inhibits the growth of the mammary tumor induced by 7... | 02/21/1989 |
| 4780495 | N -(substituted)--(3,5-dialkyl-4-hydroxyphenyl)-,-disu bstituted acetamides, and composition stabilized therewith N-(substituted)-1-(piperazinealkyl)--(3,5-dialkyl-4-hydroxyphenyl)-. alpha.,-disubstited acetamides, are novel compounds prepared by a novel modification of the ketoform process. The compounds are useful as stabilizers for organic materials s... | 10/25/1988 |
| 4757074 | Piperazinyl benzyl acids having antihistamine activity The present invention provides compounds of the formula (I): ##STR1## or salts, esters or amide derivatives thereof, wherein R1 is --CO2 H, --CH.dbd.CH--CO2 H, --(CH2)n CO2 H, or --O--... | 07/12/1988 |
| 4745191 | 1-((A-substituted phenyl-ω-substituted piperazinyl)alkenyl) cyclohexanol The compounds ##STR1## in which R1 is 3-hydroxy, 4-hydroxy, 3-methoxy, 4-methoxy or 3,4-methylenedioxy; n is 1 or 2; and R2 is ##STR2## where R3 is hydrogen, alkoxy of 1 to 6 carbon atoms, halo or trifluorom... | 05/17/1988 |
| 4618611 | 1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation and pharmaceutical compositions containing them The invention relates to new aminopropanol derivatives of the formula (I) ##STR1## wherein R1 is halogen, trihalomethyl, alkoxy having from one to 3 carbon atoms or alkyl having from one to 3 carbon atoms, R2 is alkyl having from one... | 10/21/1986 |
| 4504663 | 3-Hydroxyalkyl-3,4-dihydro-1-substituted isoquinolines The present invention concerns novel heterocyclic aminoalcoyl derivatives having the formula: ##STR1## wherein n=1, 2 or 3; A represents a nitrogen atom or the CH group, X=CH2 or CH2 O; R represents a phenyl nucleus possibly ... | 03/12/1985 |
| 4486349 | Process for preparing para-quinone or ortho-quinone derivatives, possibly alkoxylated or aryloxylated, respectively from the corresonding hydroquinone or pyrocatechic derivatives Process for preparing a para-quinone or ortho-quinone derivative, possibly alkoxylated or aryloxylated, which consists in oxidizing respectively the corresponding hydroquinone or pyrocatechic derivative, by means of the complex prepared, in situ or separa... | 12/04/1984 |
| 4476129 | 4-[2-[Bis(halophenyl)methoxy]-ethyl]--(substituted phenyl)-1-piperazinealkanol derivatives, processes for their preparation and pharmaceutical preparations containing them The invention relates to new piperazine derivatives of the general formula ##STR1## in which R' and R2 each represents 1, 2 or 3 halogen atoms, which may be the same or different, R3 represents a hydrogen atom or 1, 2 or 3 halogen at... | 10/09/1984 |
| 4431851 | 3-(Hydroxyalkyl)-3,4-dihydro-1-orthohalophenyl naphthalenes The present invention concerns compounds of the formula ##STR1## wherein n=1, 2 or 3; and R' represents phenyl or orthofluorophenyl. Said compounds are used as intermediates in the preparation of heterocyclic aminoalkyl derivatives which are useful ... | 02/14/1984 |
| 4372975 | Substituted 2-benzoyl-4-chloroglycinanilide derivatives, a process for their production, and their use as medicaments The invention relates to new substituted 2-benzoyl-4-chloroglycinanilide derivatives, to a process for their production and to their use as medicaments. The new derivatives according to the invention correspond to the general formula ##STR1## in... | 02/08/1983 |
| 4348505 | Adducts from amines and di- and polyepoxides A liquid adduct is prepared from the reaction of an amine, a polyepoxide compound with a functionality greater than 2, and, optionally, a diglycidyl ether of bisphenol A and/or the hydrogenated equivalent thereof, an accelerator or a suitable solvent; sai... | 09/07/1982 |
| 4289770 | 2-Benzoyl-4-nitroanilides and their use as medicaments New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments. The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a... | 09/15/1981 |
