Famous Patents
3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7619085 | Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)pi... | 11/17/2009 |
| 7435851 | Puleganic amides The present invention provides substituted puleganic amides and compositions thereof, which are both useful as a topical treatment for skin, such as a repellant for insects and arthropods. ... | 10/14/2008 |
| 7396834 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders Compounds of general formula: wherein R1 and R2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the ma... | 07/08/2008 |
| 7381821 | Piperazine derivatives and their use as synthesis intermediates The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically... | 06/03/2008 |
| 7378412 | Pharmaceutical compounds Compounds or their salts having general formula: A-B—C—NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical. ... | 05/27/2008 |
| 7375106 | Synergistic combination of an opioid analgesic and a NSAID The invention relates to a combined pharmaceutical preparation comprising an opioid diarylmethyl piperazine compounds and a NSAID. Such a preparation in which the compounds are either given sequentially or simultaneously can be used for the treatment of pain diminis... | 05/20/2008 |
| 7312336 | Compounds with analgesic effect Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use ... | 12/25/2007 |
| 7304048 | Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds containing an aromatic system coupled through a 7-membered heterocycle to an indole-type system. ... | 12/04/2007 |
| 7253173 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders Compounds of general formula (I) wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in pa... | 08/07/2007 |
| 7241764 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders Compounds of general formula:[Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions includin... | 07/10/2007 |
| 7238712 | Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wh... | 07/03/2007 |
| 7229994 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; R2 is independently selected from ethyl and isopropyl; R3 is indepen... | 06/12/2007 |
| 7199241 | Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide The present invention relates to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide by separation of a racemic mixture using multiple column chromatography. ... | 04/03/2007 |
| 7189726 | Benzofuran derivatives as inhibitors of p38-α kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain an aromatic residue coupled to an benzofuran moiety through a piperidine. ... | 03/13/2007 |
| 7160513 | Batch reactor with injection system An apparatus and method for injection of one or more chemical components into a reaction chamber are disclosed. The apparatus includes a reaction chamber for receiving one or more libraries in a fixed position relative to the chamber and configured to form a sealed ... | 01/09/2007 |
| 7141573 | Polypharmacophoric agents One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polyphamacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists, D-3 agonists, D-4 agonists, ... | 11/28/2006 |
| 7122539 | Nitric esters and nitrate salts of specific drugs Nitric acid salts with medicines active in the respiratory system pathology treatment. ... | 10/17/2006 |
| 7115664 | Peptidomimetic ligands for cellular receptors and ion channels One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands—agonists or antagonists—for various cellular receptors, e.g., G-protein-co... | 10/03/2006 |
| 7045625 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organometallic compounds to chiral su... | 05/16/2006 |
| 7030124 | Method of treating depression with delta receptor agonist compounds Methods for treatment of depression or other affective mood disorders, such as bipolar manic depression or seasonal affective disorder, are disclosed by administration to a subject suffering or susceptible to same, of therapeutically effective diarylpiperazine compo... | 04/18/2006 |
| 6977301 | Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide The present invention relates to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide by separation of a racemic mixture using multiple column chromatography. ... | 12/20/2005 |
| 6908999 | Process for the preparation of {2-[4-α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor The invention refers to a novel process for the preparation of {2-[-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid, which comprises hydrolyzing an N,N-disubstituted {2-[-(α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetamide, wherein said substituent... | 06/21/2005 |
| 6897305 | Calcium channel drugs and uses Novel multibinding compounds are disclosed. The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel , thereby modulating the biological activities ... | 05/24/2005 |
| 6869974 | Pharmaceutical compounds Compounds or their salts having general formulas (I) and (II): wherein s is an integer equal to 1 or 2, A is the radical of a drug that satisfies certain pharmacological tests, C and C1 are bivalent radicals, and precursors of the radicals B and B1 | 03/22/2005 |
| 6867209 | Indole-type derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein | 03/15/2005 |
| 6821965 | Amidobenzamide derivatives which are useful as cytokine inhibitors The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluor... | 11/23/2004 |
| 6803465 | Optically active 4-(tert-butoxycarbonyl)piperazine compound, and method for producing the same A method for producing 1-[(substituted phenyl)phenylmethyl]piperazines useful as intermediates for pharmaceuticals and the like, more particularly, for example, to an intermediate for the production of antiallergic pharmaceuticals. A 4-(tert-butoxycarbonyl)piperazin... | 10/12/2004 |
| 6797713 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihis... | 09/28/2004 |
| 6787543 | Benzhydryl derivatives A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present in... | 09/07/2004 |
| 6686353 | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists Cyclic diamines of formula (I) or their pharmacologically acceptable acid addition salts, and their medical applications are described. These compounds inhibit the action of chemokines such as MIP-1a and/or MCP-1 on target cells, and are useful as a thera... | 02/03/2004 |
| 6680321 | Compounds with analgesic effect Compounds of the formula (I) ##STR1## as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain.... | 01/20/2004 |
| 6608066 | Tissue factor antagonists and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treating or prophylaxis of undesi... | 08/19/2003 |
| 6451801 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well... | 09/17/2002 |
| 6436942 | Enantiomers of 1[(4-chloro-phenyl) phenylmethyl]-4-[(4-methylphenyl) sulfony]piperazine Levorotatory and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine of the formula ##STR1## their preparation and use for the preparation of substantially optically pure enantiomers of 1-[(4-chloroph... | 08/20/2002 |
| 6335331 | Pseudopolymorphic forms of 2-[2-[4-[Bis (4-fluorophenyl) methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochlor... | 01/01/2002 |
| 6274583 | Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These ... | 08/14/2001 |
| 6265579 | Process for preparing piperazine-substituted aliphatic carboxylates A process is disclosed for the preparation of a piperazine-substituted aliphatic carboxylate having the formula ##STR1## where m and n are individually an integer of from 1 to 6, R and R' are the same or different and are hydrogen, C1 to C... | 07/24/2001 |
| 6262057 | Pseudopolymorphic forms of 2-[2-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochlori... | 07/17/2001 |
| 6255487 | Process of preparing [2-(1-piperazinyl)ethoxy]methyl compounds The present invention relates to novel substituted [2-(1-piperazinyl)-ethoxy]methyl compounds of formula ##STR1## in which R1 represents a --CONH2, --CN, --COOH, --COOM or --COOR3 group, M being an alkali metal and R3... | 07/03/2001 |
| 6239277 | Process for preparing piperazine-substituted aliphatic carboxylates A process is disclosed for the preparation of a piperazine-substituted aliphatic carboxylate having the formula ##STR1## where m and n are individually an integer of from 1 to 6, R and R' are the same or different and are hydrogen, C1 to C... | 05/29/2001 |
