Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7417043 | Modulators of dopamine neurotransmission A 3-substituted 4-(phenyl-N-alkyl)-piperazine compound of the following formula: wherein R1 is selected from the group consisting of OSO2CF3, OSO2CH3, SO2R | 08/26/2008 |
| 7390812 | N, N'-disubstituted piperazine compounds and their use as analgesics N,N′-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N′-disubstituted piperazine compounds for the production of pharmaceutical preparations and in related methods... | 06/24/2008 |
| 7256289 | Process for making chiral 1,4-disubstituted piperazines A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set f... | 08/14/2007 |
| 7241765 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 07/10/2007 |
| 7226925 | Compounds, their use and preparation The invention relates to compounds of the general Formula (I): The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related ... | 06/05/2007 |
| 7186277 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring In one embodiment, the disclosure relates to a composition for dyeing keratin fibres, for example, human keratin fibres such as the hair, comprising at least one para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring, the nitr... | 03/06/2007 |
| 7153858 | Arylpiperazinyl compounds The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formulae I: and II, and synthesis and uses of those compounds for treating diseases including those mediated directly or indirectly by 5-HT rec... | 12/26/2006 |
| 7105521 | Eugenosedin-A based pharmacoligical agents The present invention provides isoeugenol derivative compounds having the moiety and having α2-adrenergic/5-HT2A antagonist, 5-HT re-uptake inhibition, and anti-oxidant activities. ... | 09/12/2006 |
| 7090703 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers The disclosure relates to novel para-phenylenediamine derivatives containing a cyclic diaza group, substituted with a cationic radical, as well as to the dye compositions comprising them, and to the method of dyeing keratin fibers using these compositions. Th... | 08/15/2006 |
| 7071197 | N,N-disubstituted diazocycloalkanes N,N-Disubstituted diazocycloalkanes of the formula I (R1=halogen, R2=(C3–C8)-cycloalkyl, R3=(C1–C4)-alkoxy... | 07/04/2006 |
| 7067501 | Aryloxyphenyl and arylsulfanylphenyl derivatives The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors. ... | 06/27/2006 |
| 7019137 | Process for making chiral 1,4-disubstituted piperazines A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth h... | 03/28/2006 |
| 6964963 | Preparation of 4-amino-1-naphthol ethers The present invention describes a process for preparing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are first prepared from 1-naphthols, the former are then converted to the corresponding 4-acetamino-1-naphthol ethers and then the acyl g... | 11/15/2005 |
| 6953801 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 10/11/2005 |
| 6894052 | Diarylalkylpiperazines active on the lower urinary tract Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the administration of the novel compounds of the invention, and other compound... | 05/17/2005 |
| 6887878 | KMST isoeugenol derivatives and pharmaceutical activity A compound having the following formula I: where R1 is an alkyl group or an alkenyl group, X represents R2 is selected from... | 05/03/2005 |
| 6887876 | Benzamidine derivatives Benzamidine derivatives are useful delta-opioid receptor modulators, agonists useful as analgesics and antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psy... | 05/03/2005 |
| 6780994 | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia This invention relates to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively ... | 08/24/2004 |
| 6686360 | N-benzylpiperazine compounds The present invention relates to a compound selected from those of formula (I): ##STR1## wherein: R1 represents alkyl, R2 represents hydroxy, alkoxy, or amino, n represents an integer from 1 to 12 inclusive, R3 represents: hydr... | 02/03/2004 |
| 6660859 | Arylpiperazines having activity at the serotonin 1A receptor Described herein is a series of aryl piperazine compounds of the formula: ##STR1## wherein Ar' is a mono or bicyclic aryl or heteroaryl radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1 -... | 12/09/2003 |
| 6569861 | Melanin concentrating hormone receptor ligands Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein Q, X, Y, Z, and R1 R9, and R12 -R19 are defined herein. These compounds are selective modulators of MCH 1 rec... | 05/27/2003 |
| 6544996 | 1-phenyl-4-(1-[2-aryl]cyclopropyl) methylpiperazines: dopamine receptor ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof wherein: R1, R2, R3 R4 and R5, R6, R7, and R8 represent organic and/o... | 04/08/2003 |
| 6525199 | Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: ##STR1## wherein R1 to R4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R5 represents... | 02/25/2003 |
| 6514976 | Arylpiperazines having activity at the serotonin 1A receptor Described herein is a compound of the formula ##STR1## wherein Ar' is a mono or bicyclic aromatic or heteroaromatic radical substituted with one to three substituents selected from the group consisting of hydrogen, (C1 -C6)alkyl, (C | 02/04/2003 |
| 6469010 | Medicament for the alleviation or treatment of symptom derived from the ischemic disease and compound useful thereof A medicine having the following basic structure, for the alleviation or treatment of symptoms derived from ischemic diseases and seizures, epilepsy, and migraine, having a powerful action in suppressing cytotoxic Ca2+ overload and free from sid... | 10/22/2002 |
| 6423717 | Sulphonamide derivatives, process for their preparation, and their use as medicaments Novel sulphonamide derivatives having CNS activity, processes for their preparation and their use as medicaments are disclosed. The present compounds are of formula (I) or a salt thereof: ##STR1## wherein: P isbenzothiophene, benzothiadiazole, quinoline, ... | 07/23/2002 |
| 6407099 | Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: ##STR1## wherein R1 to R4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R5 represents... | 06/18/2002 |
| 6395739 | N-phenyl-N'-phenylpopylpiperazine derivatives and process for the preparation The present invention is directed to an N-phenyl-N'-phenylpropylpiperazine derivative represented by formula (1): ##STR1## (wherein R1 represents a lower alkyl group; R2 represents a lower alkoxy group; and R3 represents a... | 05/28/2002 |
| 6376495 | Antidiabetic piperazine derivatives, processes for their preparation and compositions containing them Piperazine derivatives of formula (I) ##STR1## wherein Z, X, n, Ar and i have the meanings defined herein are usefull in the treatment of pathologies associated with insulin-resistance syndrome.... | 04/23/2002 |
| 6362338 | Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia This invention relates to a series of substituted piperazines of Formula II, as well as enantiomers thereof ##STR1## These compounds are useful in the manufacture of pharmaceutical compositions.... | 03/26/2002 |
| 6358515 | Hydroquinone derivatives A hydroquinone compound is represented by the following formula ##STR1## or a pharmacologically acceptable salt thereof with W, R, R1-4, and B1-2 defined herein.... | 03/19/2002 |
| 6331629 | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof, wherein: X, Y and Z are the same or different and represent optionally substituted carbon or nitrogen; R1 and R2 independently represe... | 12/18/2001 |
| 6313297 | Base-catalyzed synthesis of 1-aryl-4-(aryl ethyl)piperazines from aromatic olefins and 1-arylpiperazines A process for preparing a 1-aryl-4-(arylethyl)piperazine of the formula (I) ##STR1## by reacting a 1-arylpiperazine of the formula (II) ##STR2## with an aromatic olefin of the formula (III) Ar'CR1.dbd.CHR.sup.2 (III) in an inert solvent in the pres... | 11/06/2001 |
| 6245767 | Monohydrates of aminobenzenesulfonic acid derivatives and method for preparing thereof A monohydrate of an aminobenzenesulfonic acid derivative represented by the following formula (I), for example, 2-(1-piperazinyl)-5-methylbenzenesulfonic acid, is substantially free from weight change due to moisture absorption and can be weighed accurate... | 06/12/2001 |
| 6239135 | Arylpiperazines having activity at the serotonin 1A receptor A series of aryl piperazine compounds of the formula: ##STR1## or the pharmaceutically acceptable salts thereof, are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds ar... | 05/29/2001 |
| 6218394 | 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1## wherein one of X and Y is CH2, and the other one is CH2, O or S; ... | 04/17/2001 |
| 6197770 | Alkenyl- and alkynl-containing metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): #... | 03/06/2001 |
| 6194414 | Radioprotectors A compound of the formula: ##STR1## is disclosed. This compound is useful in methods of protecting a subject of of protecting biological materials from radiation damage.... | 02/27/2001 |
| 6166020 | Aryl and heteroaryl alkoxynaphthalene derivatives Compounds of the formula ##STR1## wherein R1, R2, R4, R23, R24, R25 and R26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent sero... | 12/26/2000 |
| 6121267 | Substituted piperazines and piperidines as central nervous system agents Di- and tri-Methoxybenzyl substituted piperazines and piperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly ... | 09/19/2000 |
