Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8008492 | Compounds that act as a vehicle for delivery through the blood-brain barrier and charge delivery vehicle constructions Compounds of formula (I), where R1 and R3 are H or (C1-C4)-alkyl; R2 is H or a C-radical derived from one of the known ring systems with 1-4 rings; X1 is a (C1-C6)-alkyl biradica... | 08/30/2011 |
| 7714131 | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member ... | 05/11/2010 |
| 7384943 | Substituted chroman derivatives The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I) wherein X is N; Y is NR2CH2, CH2 | 06/10/2008 |
| 7208497 | Substituted piperazines and diazepanes A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of dis... | 04/24/2007 |
| 7176207 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where A, a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate... | 02/13/2007 |
| 7094895 | Tyrosyl derivatives and their use as P2X7 receptor modulators The present invention relates to compounds of the formula wherein R1 and R2 are independently hydrogen, C1–C4 alkyl, C1–C4 substituted alkyl, C1–C4 alkoxy, C1â... | 08/22/2006 |
| 7026323 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmace... | 04/11/2006 |
| 6872825 | Peptide β-turn mimetic compounds and processes for making them The subject invention involves compounds having structure (I), wherein: (a) R1 is hydrogen or alkyl; and R2 is selected from hydrogen, alkyl, aryl, heterocyclyl, carboxy and its esters and amides; or R1 and R2 are attached and are together alkylene or heteroalkylene... | 03/29/2005 |
| 6858599 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 02/22/2005 |
| 6818637 | Polyhydroxypyrazine derivatives, their preparation and the pharmaceutical compositions which comprise them The invention concerns novel derivatives of formula (I) wherein: R1 represents the stereoisomeric forms of the chain —(CHOH)3—CH2—O—COR (II) and either R2 represents ... | 11/16/2004 |
| 6809202 | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in... | 10/26/2004 |
| 6635786 | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the... | 10/21/2003 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6534509 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): ##STR1## wherein R1a, R2, R3, R4, R5, and R6 are descried herein. These derivatives ar... | 03/18/2003 |
| 6531476 | Piperazine derivatives inhibiting human immunodeficiency virus replication The invention concerns the use of a piperazine derivative of formula (I) ##STR1## wherein: A and B=C.dbd.O, C.dbd.S or CR7 R8 with R7 =H, methyl, cyano, cyanomethyl, CO2 CH3 or (C.dbd.O)CH3 and ... | 03/11/2003 |
| 6521619 | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents The present invention relates to novel cyclopropane-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or ... | 02/18/2003 |
| 6492368 | Benzamidine derivatives as factor XA inhibitors Novel compounds of the formula I ##STR1## in which X, Y, R1, R2 and R3 are as defined in Patent Claim 1 are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.... | 12/10/2002 |
| 6441172 | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl group and 6... | 08/27/2002 |
| 6399613 | Pyrazine derivatives, their preparation and medicaments containing them The invention concerns pyrazine derivatives of formula (1) in which a pharmaceutical composition comprising at least one compound of formula: ##STR1## in which R represents a nitrogen atom, R1 and R3 each represent the same radical s... | 06/04/2002 |
| 6344466 | Benzamide and sulfonamide substitued aminoguanidines and alkoxyguanidines as protease inhibitors The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: ##STR1## wherein X is O or NH, L is --O-- or --SO2 --, and R1 -R4, R9 -R19, Ra... | 02/05/2002 |
| 6340682 | Diamide compound and drugs containing the same The present invention provides diamide derivatives represented by the following general formula (1): ##STR1## wherein A is a phenyl group or the like, which may be substituted, B is --CH.dbd.CH--, --C.dbd.C--, --(CH.dbd.CH)2 --, --C.ident.... | 01/22/2002 |
| 6303611 | Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula having the structure: ##STR1## wherein R1, R2, and X Y, Z, Ar and n are as describe... | 10/16/2001 |
| 6143893 | 1,4-bis{ଲ-[N-methyl-N-(2-hydroxyethyl)amino]propionyl}piperazine and process for its preparation The compound of formula is useful as chain extender in the preparation of polymers, in particular of linear and cross-linkable, heparinizable, biocompatible polymers.... | 11/07/2000 |
| 6057323 | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formula I, having the structure: ##STR1## wherein R1, R2 ... | 05/02/2000 |
| 6022873 | Metalloproteinase inhibitors Compounds of formula (I) ##STR1## wherein n, V, R1, R2, R3 and R4 are as defined in the specification are matrix metalloproteinase inhibitors.... | 02/08/2000 |
| 6001835 | Inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 12/14/1999 |
| 5977114 | Selective thrombin inhibitors The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R1 represents acetyl substituted with aryl or aryloxy, or repres... | 11/02/1999 |
| 5929077 | Thioproline-containing inhibitors of farnesyl protein transferase Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected b ##STR1## its enantiomers, diastereomers, and pharmaceutically acceptable salts and solvates thereof.... | 07/27/1999 |
| 5892039 | Piperazino derivatives as neurokinin antagonists The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.... | 04/06/1999 |
| 5886181 | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives Optically active piperazine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein R1 and R2 are inter alia hydrogen, alkyl or acyl and X is alkoxy or a (substituted) amino group, are prepared by asymmetric ... | 03/23/1999 |
| 5869554 | Polycarbonate compositions comprising hindered amine light stabilizers and ultraviolet light absorbers Weatherable polycarbonate compositions (formulations or blends) comprise at least one of a piperazinone and piperazine dione based HALS, and at least one of a benzotriazole, benzophenone, triazine, oxanilide, and cyanoacrylate based UVA. The combination o... | 02/09/1999 |
| 5756504 | Tocolytic oxytocin receptor antagonists Compounds of the formula X--Y--R, or the pharmaceutically acceptable salts and esters thereof, wherein X is ##STR1## Y is --SO2 --, --(CH2)p -- or --CO--(CH2)p --; R is unsubstituted or substitut... | 05/26/1998 |
| 5756742 | Polymerizable compounds Polymerizable compounds based on N-acylamido-piperazines are provided. Such compounds have the formula: ##STR1## wherein: a, b, c and d are independently 0 or 1 and the sum of a, b, c and d is at least 3. R1, R2, and R3 | 05/26/1998 |
| 5756505 | N-acylpiperazine derivative, antibacterial drug and anti-ulcer drug An N-acylpiperazine derivative or a salt thereof in accordance with the present invention is represented by the following formula 1: ##STR1## wherein R1 represents a lower alkyl, hydroxy lower alkyl, lower acyl, or arylcarbonyloxy lower al... | 05/26/1998 |
| 5736539 | Inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 04/07/1998 |
| 5670505 | Piperazine derivatives A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl; Y is a direct bond or lower alkylene; and R1, R2, R3, R4 are as defined herein. The compounds are advantageously used as Tachyki... | 09/23/1997 |
| 5654465 | Process for the production of cyanocinnamamides This invention provides a process for producing cyanocinnamamides. More particularly, the invention provides a process for condensing an cyanoacetamide with a carbonyl-containing compound to produce cyanocinnamamides in good yield.... | 08/05/1997 |
| 5650412 | HIV protease inhibitors useful for the treatment of AIDS Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ... | 07/22/1997 |
| 5646151 | Kappa agonist compounds and pharmaceutical formulations thereof Compounds, compositions and method of treating hyperalgesia comprising a compound of formula I, II, III and IV as defined in the specification.... | 07/08/1997 |
| 5612479 | Polyphenols containing mesogenic moieties as lateral substituents Novel polycyanate compositions containing one or more mesogenic moieties as lateral substituents are disclosed which provide improved processability relative to polycyanates containing one or more mesogenic moieties in the main chain of the molecule. Mole... | 03/18/1997 |
