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| Number | Title | Issue Date |
| 8158790 | Cyclic amine compound The present invention provides an excellent antihypertensive medicament. The medicament of the present invention comprises a compound having the general formula (I) and the like: [wherein R1 | 04/17/2012 |
| 7393852 | Piperazine derivatives and methods of use Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for... | 07/01/2008 |
| 7268140 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory... | 09/11/2007 |
| 7132539 | Melanocortin receptor ligands The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1–C12 linear or branched alkyl, C3–C8 cyc... | 11/07/2006 |
| 7115611 | Phenyl derivatives, their manufacture and use as pharmaceutical agents This invention relates to compounds of the formula wherein one of R5, R6 and R7 is | 10/03/2006 |
| 7109259 | Piperazinone derivatives A compound of the formula (I) wherein n is preferably 3; G1, G2, G3 and G4 are independently of one another e.g. C | 09/19/2006 |
| 7105507 | Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R | 09/12/2006 |
| 7041826 | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula I that makes use of a novel piperazine derivative, 4-Benzyl-1-methyl-2-oxo-3-phenylpiper... | 05/09/2006 |
| 7022851 | PNA monomer and precursor This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: | 04/04/2006 |
| 6911447 | Melanocortin receptor ligands Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic... | 06/28/2005 |
| 6906074 | 2-phenylpiperazine derivatives A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof: wherein each of X1 and X3 is oxygen or two hydrogen atoms, X... | 06/14/2005 |
| 6903128 | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases There is disclosed a genus of non-peptidyl compounds, wherein said compounds are VLA-4 inhibitors useful in treating inflammatory, autoimmune, and respiratory diseases, and wherein said compounds comprise a compound of Formula (1.0.0): | 06/07/2005 |
| 6858599 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 02/22/2005 |
| 6852855 | Synthesis of piperazine ring A novel process for preparing a compound of the formula I: wherein R1 denotes substituted or unsubstituted alkyl, alkoxy, aryl, aryloxy or arylalkoxy; R2 denotes substituted or unsubstit... | 02/08/2005 |
| 6818645 | Benzocycloalkylenylamine derivatives as muscarinic receptor antagonists This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S, or NR4, and the other substituents are as d... | 11/16/2004 |
| 6809202 | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in... | 10/26/2004 |
| 6787543 | Benzhydryl derivatives A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present in... | 09/07/2004 |
| 6770637 | Substituted 4-phenyl-pyridine compounds with activity as antagonists of neurokinin 1 receptors Substituted 4-phenyl-pyridine compounds with activity as antagonists of Neurokinin 1 receptors, methods of making these compounds and preparing. ... | 08/03/2004 |
| 6762226 | Compositions stabilized by dioxopiperazinyl derivatives Polyoxymethylene, blends of polycarbonate with acrylonitrile-butadiene-styrene terpolymer, and coatings based on a functional acrylate resin and a crosslinking agent, which are stabilized by addition of a compound of the formula I | 07/13/2004 |
| 6743915 | Poly (1,4-ethylene-2-piperazone) composition, method for production of a poly(1,4-ethylene-2-piperazone), composition TCE-detecting method and sensor A composition of matter has the formula: where n is an integer equal or greater than 1. The composition of matter possesses characteristic absorbance behavior with respect to infrared and visible energy, which is used to... | 06/01/2004 |
| 6730783 | Process for preparing aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 05/04/2004 |
| 6677336 | Substituted piperazine compounds Novel compounds of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subse... | 01/13/2004 |
| 6642383 | Oxopiperazinyl derivatives and light stabilized compositions Compounds of the formula (I) ##STR1## wherein p is zero or 1; q and r, independently of each other, are an integer from 1 to 6; and s is a number ranging from 1 to 8; X is --O-- or, when p is 1, X is also a group ##STR2## Rw, R | 11/04/2003 |
| 6638931 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 10/28/2003 |
| 6579881 | Indoles A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3 | 06/17/2003 |
| 6518310 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 02/11/2003 |
| 6515159 | S,S-ethylenediamine-N,N'-disuccinic acid iron alkali salt and a process for production thereof An S,S-ethylenediamine-N,N'-disuccinic acid iron alkali salt which contains a lactam compound represented by the following general formula (1): ##STR1## wherein M is an ammonium ion or an alkali metal ion, and an ethylenediaminemonosuccinic acid represent... | 02/04/2003 |
| 6509337 | Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors A compound of the formula ##STR1## wherein R1 -R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidem... | 01/21/2003 |
| 6498162 | Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula ... | 12/24/2002 |
| 6472397 | Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof The compounds represented by the formula (I), and pharmacologically acceptable salts and solvates thereof are disclosed. The compound is hydrolyzed in organisms into a compound represented by the formula in which W represents a hydrogen atom, and D repres... | 10/29/2002 |
| 6448243 | 1,4-substituted cyclic amine derivatives A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R1, R2, R3, ... | 09/10/2002 |
| 6441172 | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl group and 6... | 08/27/2002 |
| 6387389 | Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions comprising the same, and a method of using such sustained-r... | 05/14/2002 |
| 6376428 | Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production The dihalopropene compounds of the general formula [I] have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.... | 04/23/2002 |
| 6369225 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6369063 | Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 04/09/2002 |
| 6316623 | Ethylenediamine compound libraries Libraries of ethylenediamine compounds having the general formula (I): ##STR1## wherein R1 to R6, m, n, o and p are as defined herein, are prepared using solid phase combinatorial chemistry techniques. A heterocyclic alcohol is reacted with an ethylenedia... | 11/13/2001 |
| 6288038 | Depsipeptide derivatives bearing piperazinone rings The present invention provides a new depsipeptide derivative having a piperazinone ring within the molecule which is represented by formula (1) ##STR1## wherein X1 represents N(R4)--CO, N(R5)--CH2, CH2 --C... | 09/11/2001 |
| 6274584 | Compounds with growth hormone releasing properties Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (1): ##STR1## wherein a, b, A, R1, L1, D... | 08/14/2001 |
| 6235778 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 14 R4, R6 -R9, R11, R12, Ra, Rb, R | 05/22/2001 |
