Class 544/382 - Nitrogen attached directly to the piperazine ring by nonionic bonding

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein nitrogen is attached directly to the piperazine
No. of patents: 111
Last issue date: 06/24/2008

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Number	Title	Issue Date
7390908	Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or preventio...	06/24/2008
7199239	Chemical compounds A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, Wherein: R1 and R2 are independently hydrogen or C...	04/03/2007
7153858	Arylpiperazinyl compounds The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formulae I: and II, and synthesis and uses of those compounds for treating diseases including those mediated directly or indirectly by 5-HT rec...	12/26/2006
7084144	Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction A compound having the general formula (I): wherein: X is N or C; R0 is H, a lower alkyl group, a lower O-alkyl group, lower alkyl group, a benzyl ...	08/01/2006
7049306	Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4. Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su...	05/23/2006
7034110	Method of identifying chemical compounds having selected properties for a particular application A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reac...	04/25/2006
6992081	Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases. ...	01/31/2006
6897218	Nitric oxide donors based on metallic centers A metal complex of a piperazineNONOate derivative of the formula: wherein a) R1 and R2 independently represent hydrogen, linear or branched (C1-C4) alkyl, optionally substitu...	05/24/2005
6762178	Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and de...	07/13/2004
6713651	β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor....	03/30/2004
6683115	댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and prem...	01/27/2004
6680317	IL-8 receptor antagonists This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8)....	01/20/2004
6667309	Cyclobutene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the ...	12/23/2003
6596863	Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ...	07/22/2003
6593497	댢-adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댢 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the...	07/15/2003
6552025	Diimino-piperazine derivatives for use as modulators of cell regulation Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The preferred derivative is 2,6-bis-(ω-aminobutyl)-3,5-diimino...	04/22/2003
6545152	R-isomers of nonnucleoside inhibitors Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT...	04/08/2003
6541669	댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and prem...	04/01/2003
6528514	IgE antibody production inhibitors and autoimmune diseases inhibitors The present invention relates to an IgE antibody production inhibitor and an autoimmune disease suppressant containing a heterocyclic amide compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an activ...	03/04/2003
6498162	Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds The invention relates to new arylglycinamide derivatives of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula ...	12/24/2002
6479485	Benzamidine derivatives and their use as anti-coagulants This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states...	11/12/2002
6451792	Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof....	09/17/2002
6420560	H1--histamine receptor antagonists This invention relates to novel multibinding compounds (agents) that are H1 histamine receptor antagonists and pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions of this invention...	07/16/2002
6369225	Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##...	04/09/2002
6355800	Process for producing aminopiperazine derivatives A new industrial process excellent in yield and purity for preparing a compound of the formula: ##STR1## or a salt thereof in a less number of steps with a synthetic pathway without proceeding via nitroso compounds, wherein R1 is lower aryl, ar...	03/12/2002
6291464	Aminopiperazine derivatives This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity, etc., and represented by general formula [I]. ##STR1## wherein R1 is lower alkyl, etc., R2 is aryl, etc., A is ##STR2## or --SO	09/18/2001
6248743	Butadiene derivatives and process for preparing thereof A novel butadiene derivative of the formula: ##STR1## wherein Ring A is heterocycle, or benzene being optionally substituted by lower alkyl, alkoxy, nitro, hydroxy, substituted or unsubstituted amino or halogen, Ring B is heterocycle, or benzene being opt...	06/19/2001
6242600	2-piperazinone-1-acetic acid derivatives and their use The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention inhibit platelet aggregation action without remarkable...	06/05/2001
6147079	N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide hydrate Hydrates of N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide, which are stable against heat, light, and humidity, are described. The material is easy to handle under ordinary interior humidity conditions. N-(4-acetyl-1-piperazinyl)-4-fluorobenzamide hydrate i...	11/14/2000
6130221	Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions Compositions comprising a pharmaceutically effective amount of a compound that impedes disruption of intact dense microspheres (DMS) by acting on DMS either to prevent disruption, or if disrupted, act on pre-disrupted DMS in such a way that, when the comp...	10/10/2000
6114325	1,2-di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same A 1,2-di-substituted benzene-carboxamide derivative or a salt thereof expressed by the following Formula (I); ##STR1## wherein each of A and B is R1 or --(CH2)n-NR2 R3, wherein when A is R1, B is...	09/05/2000
6054457	Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower...	04/25/2000
6043247	Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel substituted acrylic acids, to methods for their preparation, compositions containing them, and their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to...	03/28/2000
6017917	Guanidine derivatives Guanidine derivatives of the formula: ##STR1## wherein R1 is [di(lower)alkylamino](lower)alkyl, morpholinyl(lower)alkyl, lower alkylpiperazinyl or [lower alkylpyrrolidinyl](lower)alkyl, R2 is halogen, lower alkyl or lower alkoxy...	01/25/2000
5962487	Antipicornaviral compounds and methods for their use and preparation Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating p...	10/05/1999
5919777	Compounds with growth hormone releasing properties The present invention relates to novel compounds of the general formula I ##STR1## which can be used for treating medical disorders resulting from a deficiency in growth hormone....	07/06/1999
5917044	Phenolic amides and their use as stabilizers Phenolic amides, useful as stabilizers for organic materials such as polyols and polyurethanes, possess the general formula ##STR1## wherein n is 0 to 3, R1, is alkyl of from 1 to about 6 carbon atoms, R2 is hydrogen or alkyl of...	06/29/1999
5914351	Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a...	06/22/1999
5912244	Benzopyrans A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein X is O, S or NH; R and R1 are each independently selected from H and C1 -C4 alkyl or taken together represent C2 -C...	06/15/1999
5814656	Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tiss...	09/29/1998

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Class 544/382 - Nitrogen attached directly to the piperazine ring by nonionic bonding