Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7893263 | Structural analogs of corosolic acid having anti-diabetic and anti-inflammatory properties This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. Th... | 02/22/2011 |
| 7427632 | Factor Xa inhibitors Compounds of formula (I) in which R1, n, Z, R3 and R4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment of ... | 09/23/2008 |
| 7384943 | Substituted chroman derivatives The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I) wherein X is N; Y is NR2CH2, CH2 | 06/10/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7271168 | Piperazine derivatives having SST1 antagonistic activity The invention provides compounds of formula (1) wherein X, R1 and R2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety an... | 09/18/2007 |
| 6916812 | Alpha-aminoamide derivatives as melanocortin agonists Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of the melanocortin receptors. The compounds of the present inven... | 07/12/2005 |
| 6916816 | Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents Disclosed are compounds of formula (I) wherein: L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than hydrogen; A is CH2, SO2 or C═O; X is CO2... | 07/12/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6858599 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 02/22/2005 |
| 6846925 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1; R2 and R3 are each independently hydroxy, phosphoryloxy (—OP3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydro... | 01/25/2005 |
| 6831084 | Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, diabetic per... | 12/14/2004 |
| 6828324 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT1A activity This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, diabetic per... | 12/07/2004 |
| 6821967 | Substituted piperazine derivatives, the preparation thereof and their use as medicaments The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, ... | 11/23/2004 |
| 6818644 | Substituted piperazine derivatives, the preparation thereof and their use as medicaments The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc Rf, Rg and m, n and X ... | 11/16/2004 |
| 6730784 | Urea derivatives useful as synthetic intermediates Objects of the present invention are to create compounds having urea structure as basic structure and having a sulfur atom and an amide bond in side chains and to find pharmacological effects thereof, particularly TNF-α production inhibitory effects. The pre... | 05/04/2004 |
| 6720323 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1, R2 and R3 are each independently hydroxy, phosphoryloxy (—OPO3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydr... | 04/13/2004 |
| 6713651 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 03/30/2004 |
| 6703385 | Tricyclic compounds having sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): ##STR1## wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocycl... | 03/09/2004 |
| 6683115 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and prem... | 01/27/2004 |
| 6593497 | 댢-adrenergic receptor agonists The present invention is directed to multibinding compounds which are 댢 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the... | 07/15/2003 |
| 6541669 | 댢-adrenergic receptor agonists Disclosed are multibinding compounds which are 댢 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and prem... | 04/01/2003 |
| 6492355 | Adamantane derivatives The invention provides compounds of general formula ##STR1## in which m, A, R1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the phar... | 12/10/2002 |
| 6451801 | Compounds and methods for treatment of asthma, allergy and inflammatory disorders The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well... | 09/17/2002 |
| 6387389 | Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions comprising the same, and a method of using such sustained-r... | 05/14/2002 |
| 6323206 | Chemokine receptor antagonists and methods of use therefor Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following st... | 11/27/2001 |
| 6274583 | Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These ... | 08/14/2001 |
| 6184224 | Antitumor dibenzofluorene derivatives Dibenzofluorene derivatives having a formula selected from the group consisting of ##STR1## and salts thereof have antitumor activity. At least one of R1 -R13 in formula (I) or R1 -R12 in formula (II) is --... | 02/06/2001 |
| 6133268 | 1,4-disubstituted piperazines The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ... | 10/17/2000 |
| 6130221 | Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions Compositions comprising a pharmaceutically effective amount of a compound that impedes disruption of intact dense microspheres (DMS) by acting on DMS either to prevent disruption, or if disrupted, act on pre-disrupted DMS in such a way that, when the comp... | 10/10/2000 |
| 6130220 | Sulfamide-metalloprotease inhibitors This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 10/10/2000 |
| 6096888 | Anthracyclinone derivatives and their use in amyloidosis The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and p... | 08/01/2000 |
| 6063924 | Soluble chromophores containing solubilising groups which can be easily removed Compounds of formula A(B)x (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxa... | 05/16/2000 |
| 6057441 | Substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R1 and R | 05/02/2000 |
| 6048877 | Tetralone derivatives as antiarrhythmic agents Tetralone derivatives of the formula ##STR1## where R1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, ... | 04/11/2000 |
| 6025493 | N-piperazinylalkyl-2-anthracenecarboxamides Disclosed arm compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R | 02/15/2000 |
| 6015900 | N-aminoalkylfluorenecarboxamides Disclosed are compounds of formula (I) or the pharmaceutically acceptable salts thereof wherein: ##STR1## G represents a group of the formula (a), (b) or (c) where Ra and Rb represent hydrogen, or organic or inorganic substituen... | 01/18/2000 |
| 5998615 | Anthracyclinone derivatives The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and p... | 12/07/1999 |
| 5998412 | Sulfamide-metalloprotease inhibitors This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 12/07/1999 |
| 5994543 | Antibiotic bravomicins A novel class of antibiotics, designated bravomicins, is obtained by fermentation of a strain of Micromonospora polytrota. Six bioactive compounds, designated bravomicins A, B, C, D, E and F, are obtained and found to be useful in the treatment of a wide ... | 11/30/1999 |
