Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 7439238 | Antiparasitic artemisinin derivatives (endoperoxides) This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substitued derivatives of artemisinin, processes f... | 10/21/2008 |
| 7312242 | Use of parthenolide derivatives as antileukemic and cytotoxic agents Compounds of the formula having anti-tumor activity, wherein R1 and R2 are as described herein ... | 12/25/2007 |
| 7244730 | 2-iminopyrrolidine derivatives A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, et... | 07/17/2007 |
| 7189757 | Treatment of sleep disorders using CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder. Furthermore, the invention provides methods of treating sleep disorders using c... | 03/13/2007 |
| 6984640 | Antiparasitic artemisinin derivatives (endoperoxides) This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substituted deriviatives of artemisinin, processes... | 01/10/2006 |
| 6699858 | Halogen substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2, 3, 4, 5 or 6; X is CH2 or O; R1 | 03/02/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6514967 | Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same The invention relates to compounds of the following general formula (I): ##STR1## in which: R1 and R2 represent a hydrogen atom, or form a ring, especially a benzene ring, R3 represents a hydrogen atom or an alkyl group, e... | 02/04/2003 |
| 6462041 | Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by the general Formulae I-III: ##STR1## wherein R1 -R5 are defined herein. The present invention also relates to the discovery that comp... | 10/08/2002 |
| 6458803 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 10/01/2002 |
| 6455520 | Benzamide derivatives and their use as cytokine inhibitors The invention concerns amide derivatives of formula (I) ##STR1## wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R | 09/24/2002 |
| 6340704 | Cell differentiation inducing amide derivatives, their production and use The present invention provides a compound represented by the formula: ##STR1## wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which m... | 01/22/2002 |
| 6323206 | Chemokine receptor antagonists and methods of use therefor Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following st... | 11/27/2001 |
| 6153611 | Piperazinyl-cyclohexanes and cyclohexenes Novel non-dopaminergic antiischemic compounds have Formula I: ##STR1## wherein R=R1 and is independently H, C1-4 alky C1-4 alkoxy, C1-4 trihaloalkyl or halogen, or R and R1 may be taken together ... | 11/28/2000 |
| 6113812 | Photochromic articles A photochromic article that includes a host material and a photochromic amount of a benzopyran compound, the benzopyran compound represented by one of the formulas: ##STR1## wherein R1, R2, R3, R4, R5 | 09/05/2000 |
| 6100265 | Thiopyran derivatives A thiopyran derivative represented by the following formula (I) or (I'), or the salt thereof. ##STR1## wherein A is S or --CH.dbd.CH--; the dotted line indicates that the bond may be either present or absent; Z and Z' are typically ##STR2## ... | 08/08/2000 |
| 5869490 | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one The compounds of formula I: ##STR1## wherein X is H2 or O; R1 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or di-alkylamino, alkanamido or alkanesulfonamido; Z... | 02/09/1999 |
| 5869520 | Carbamoyloxylabdanes Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 02/09/1999 |
| 5869662 | Photochromic benzopyran compounds Benzopyran compounds represented by the formulas: ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are selected from hydrogen, a stab... | 02/09/1999 |
| 5847167 | Carbamoyloxlabdanes Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 12/08/1998 |
| 5847168 | Photochromic compounds A photochromic article that includes a host material and a photochromic amount of a naphthopyran compound, the naphthopyran compound represented by the formula: ##STR1## wherein R1 ', R2 ', R3 ', R4 ', R | 12/08/1998 |
| 5798350 | Dopamine receptor ligands Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select... | 08/25/1998 |
| 5759450 | Photochromic naphthopyran compounds A naphthopyran compound represented by the formula: ##STR1## wherein R5, R6, R8, R9, and R10 are each selected from hydrogen, a first stable organic radical, an organic heterocyclic group, haloge... | 06/02/1998 |
| 5702645 | Photochromic chromene derivatives Described herein are photochromic compounds or a structural isomer of the photochromic compound, the photochromic compounds represented by the formula: ##STR1## wherein R1, R2, R4, R5, R6, R... | 12/30/1997 |
| 5646175 | Carbamoyloxylabdane compounds Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 07/08/1997 |
| 5543427 | Carbamoyloxylabdanes Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 08/06/1996 |
| 5541183 | Ginkgolide derivatives The present invention is directed to new ginkgolide derivatives, which may be used for the prevention or treatment of various PAF-induced diseases, and the pharmaceutical uses of these derivatives. The present invention is also directed to a process for p... | 07/30/1996 |
| 5538965 | Dopamine receptor ligands Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select... | 07/23/1996 |
| 5428043 | Tricyclic-cyclic amines as novel cholinesterase inhibitors Compounds of the formula ##STR1## wherein ring A, ring B, ring D, R2, R3, R4, R5, R6,R11, R12, R13, E, G, X and P are as defined below. The compounds of formula I... | 06/27/1995 |
| 5424455 | Heterocyclic compounds for making red disperse dyes A heterocyclic compound of the formula, ##STR1## wherein A and B are each hydrogen, halogen, alkyl or alkoxy, R1 is alkylene having upto 6 carbon atoms, X is direct linkage or divalent group such as --O--, --S--and the like, T and U are ea... | 06/13/1995 |
| 5374650 | Carbamoyloxylabdanes Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 12/20/1994 |
| 5332811 | Etopside analogs Compounds which are analogs of etoposide and which exhibit anti-tumor activity are disclosed. These compounds having the following structure: ##STR1## wherein R is selected from ##STR2## wherein R1, R2, R3, R | 07/26/1994 |
| 5286881 | Process for producing benzodifuranone compounds useful for dyeing or printing hydrophobic fiber materials A benzodifuranone compounds of the formula, ##STR1## wherein R1 and R2 are each independently a naphthyl group or an unsubstituted or substituted phenyl group, which is useful for dyeing or printing hydrophobic fiber materials, ... | 02/15/1994 |
| 5246930 | 9-substituted compounds of 3, 11-epoxy-3,4,5,5a,6,7,8,8a,9,11,11a-undecahydro-3ଲ,6.al pha.,9-trimethylfurano[3,4-j][1,2]benzodioxepin, processes for their preparation and their use as antiprotozoal and antiviral agents Compounds of formula I ##STR1## in which the substituted R has the given meaning, have an antimalarial and a antiviral activity.... | 09/21/1993 |
| 5238939 | Isochromane derivatives The invention concerns an isochromane derivative having the general formula I ##STR1## in which R1 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy (1-4 C), halogen, or CF3, or ... | 08/24/1993 |
| 5225436 | Aryl substituted naphthalene derivatives Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation.... | 07/06/1993 |
| 5225427 | 10-substituted ether derivatives of dihydroartemisinin, process for their preparation and their use as antiprotozoal agents 10-substituted ether derivatives of 3, 12-Epoxy-3,4,5 5a, 6,7,8,8a,9,10,12ଲ, 12a-dodecahydro-10-hydroxy-3ଲ,6,9ଲ-trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroqui... | 07/06/1993 |
| 5223616 | Heterocyclic disperse dye compound, their production and their use for dyeing or printing of hydrophobic fibers A heterocyclic compound which is useful for dyeing or printing hydrophobic fiber materials and which has the following formula (I), ##STR1## wherein A1, A2, A3 and A4 are each hydrogen, halogen, alkyl, alkoxy or... | 06/29/1993 |
| 5180717 | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol Bivalent ligand compounds synthesized from a tether composition joining two heterocyclic groups comprising furochromones, furobenzoxazinones, and benzobisdifurans. These compounds show pharmacological activity in blocking ACAT enzymes which are major regu... | 01/19/1993 |
| 5053408 | Hexitol derivatives having vasodilative activity Disclosed is a hexitol derivative represented by the formula (I): ##STR1## wherein Q represents a formula selected from the group consisting of ##STR2## wherein a represents NH, O or S; each of b, c and d independently represents CH or N; each of R | 10/01/1991 |
