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| Number | Title | Issue Date |
| 8067594 | Process for the production of benzopyran-2-ol derivatives The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; compris... | 11/29/2011 |
| 7528250 | Chroman derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for pre... | 05/05/2009 |
| 7459558 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A method of treating in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the disclosure. ... | 12/02/2008 |
| 7371756 | Use of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and its physiologically acceptable salts 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine or a physiologically acceptable salt thereof, for the treatment of sub-type anxiety disorders chosen from the sub-types: panic disorder with or without agoraphobia, agoraphobia, obsessive-comp... | 05/13/2008 |
| 7339059 | Benzofurans and indols Compounds of formula (I) wherein X is a fluorine or a chlorine atom; the methyl groups located at the 2- and 5-position of the piperazine ring are in trans-configuration to each other; | 03/04/2008 |
| 7335660 | Isochroman compounds for treatment of CNS disorders This invention relates to compounds of formula (I) where R1 to R12, —W—V—, —X—Y—, p and n have the values defined in claim 1, their preparation and use as pharmaceuticals for the tre... | 02/26/2008 |
| 7214679 | Piperidine/piperazine-type inhibitors of p38 kinase Compounds of the formula: wherein the substituents are as defined herein are useful for treating conditions mediated by p38 kinase. ... | 05/08/2007 |
| 7208497 | Substituted piperazines and diazepanes A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of dis... | 04/24/2007 |
| 7208495 | Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof A compound represented by the formula: (wherein, R1 and R2 are the same or different and each represents a hydrogen atom, hydrocarbon group or heterocyclic group, or R1 and R... | 04/24/2007 |
| 7189726 | Benzofuran derivatives as inhibitors of p38-α kinase The invention is directed to methods to inhibit p38-α kinase using compounds which contain an aromatic residue coupled to an benzofuran moiety through a piperidine. ... | 03/13/2007 |
| 7186724 | Heterocyclic substituted carbonyl derivatives and their use as dopamine Dreceptor ligands The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine... | 03/06/2007 |
| 7144883 | Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obe... | 12/05/2006 |
| 7135473 | Cyclic diamine compound with condensed-ring groups A cyclic diamine compound of formula (1): wherein R1 and R2 are individually a hydrogen atom or a methoxy group, provided R1 is a methoxy group when R2 is a hydrogen at... | 11/14/2006 |
| 7115607 | Substituted piperazinyl amides and methods of use Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceuti... | 10/03/2006 |
| 7094779 | Piperazine oxime dervatives having NK-1 receptor antagonistic activity The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity. The invention relates to compounds of the general formula (1) wherein: X represents phenyl or pyridyl substituted with 1 or 2 substituents f... | 08/22/2006 |
| 7084144 | Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction A compound having the general formula (I): wherein: X is N or C; R0 is H, a lower alkyl group, a lower O-alkyl group, lower alkyl group, a benzyl ... | 08/01/2006 |
| 7067513 | Phenylpiperazines The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances ... | 06/27/2006 |
| 7056921 | Substituted chroman derivatives The present invention relates to new new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives compound having the formula (I) wherein X is N or CH; Y is NR2 | 06/06/2006 |
| 7037913 | Bicyclo 4.4.0 antiviral derivatives This invention provides compounds of Formula I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activi... | 05/02/2006 |
| 7030241 | Mesylates of piperazine derivatives and process for their preparation The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine rin... | 04/18/2006 |
| 7026352 | Physiologically active substances The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incuba... | 04/11/2006 |
| 7026314 | Therapeutic chromone compounds Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds ... | 04/11/2006 |
| 6967201 | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1... | 11/22/2005 |
| 6953801 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 10/11/2005 |
| 6916812 | Alpha-aminoamide derivatives as melanocortin agonists Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of the melanocortin receptors. The compounds of the present inven... | 07/12/2005 |
| 6916797 | α-arylethylpiperazine derivatives as neurokinin antagonists The invention relates to new α-arylethylpiperazine of the formula wherein Z represents 0 or S; n′ represents 1 or 2; R2 represents a hy... | 07/12/2005 |
| 6855822 | Benzo[b]furan dimers Benzo[b]furan dimers and processes for their preparation are provided. The invention provides a synthetic process for the preparation of benzo[b]furan dimer using mild reaction conditions, which provides a high substituent tolerance and is appropriate for use in sol... | 02/15/2005 |
| 6846825 | Antibacterial agents Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substituted... | 01/25/2005 |
| 6825202 | Arylsulfonyl derivatives with 5-HT6 receptor affinity This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein Ar, R1, R2, R3 or R4 are as defined in the ... | 11/30/2004 |
| 6825201 | Indole, azaindole and related heterocyclic amidopiperazine derivatives The invention comprises substituted indole, azaindole and related heterocyclic amidopiperazine derivatives of general Formula I wherein: Q is | 11/30/2004 |
| 6780859 | Benzofuran and dihydrobenzofuran derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel benzofuran and dihydrobenzofuran compounds, pharmaceutical compositions containing such compounds, and methods of treating beta-3 adrenoreceptor-mediated conditions with such compositions. ... | 08/24/2004 |
| 6770650 | Cyclic amine derivatives-CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 08/03/2004 |
| 6767907 | 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the other one is CH2, O or S; Z is N, C, CH or COH;... | 07/27/2004 |
| 6762300 | Method for producing 5-(1-piperazinyl)-benzofuran-2-carboxamide by transition metal-catalyzed amination Process for the preparation of 5-(1-piperazinyl)benzofuran-2-carboxamide in which, as intermediate step, 5-bromosalicylaldehyde or one of its derivatives is reacted in a transition metal-catalysed amination with R2-piperazine, in which R2 is as... | 07/13/2004 |
| 6753331 | Heterocyclic derivatives which inhibit factor Xa The invention relates to heterocyclic derivatives of formula (I), or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also rela... | 06/22/2004 |
| 6730670 | 7-phenyl-benzo[b]thiophen amide derivatives A compound of the formula Compounds of formula I have a good affinity to the A2A receptor and are useful for the treatment of diseases mediated by this receptor. ... | 05/04/2004 |
| 6723730 | Capsaicin receptor ligands Disclosed are diaryl piperazines and related compounds of the following Formula: wherein the variables are as defined in the specification. These compounds are selective modulators of capsaicin receptors, including human... | 04/20/2004 |
| 6716987 | Derivatives of benzofuran or benzodioxazole compounds An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1 | 04/06/2004 |
| 6699864 | Substituted phenyl-piperazine derivatives, their preparation and use The present invention provides compounds of the formula: ##STR1## wherein R1 -R8, X, Y, Z, n and m are defined in the application. The compounds of the invention have affinity for the 5-HT1A receptor.... | 03/02/2004 |
| 6700025 | Process for stereoselective synthesis of prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.... | 03/02/2004 |
