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| Number | Title | Issue Date |
| 8163906 | Dihydroquinone and dihydronaphthridine inhibitors of JNK Compounds of formula I are effective modulators of JNK: wherein X is CR11 or N; Y is —C(O)R3, 5-membered heteroaryl, or 5-membered heterocyclyl; | 04/24/2012 |
| 7820820 | Method of preparation of azaindole derivatives A method of preparing azaindole compounds for antiviral use having the formula ... | 10/26/2010 |
| 7777035 | Azaindazole compounds and methods of use Methods are provided for the synthesis of 1-[4-(substituted phenyl)-piperazin-1-yl ] -2- [3-(1H-imidazol-2-yl)-pyrazolo [3,4-b]pyridin-1-yl]-ethanone compounds via construction of the imidazole portion onto the corresponding aldehyde or nitrile compounds. ... | 08/17/2010 |
| 7745625 | Prodrugs of piperazine and substituted piperidine antiviral agents This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exis... | 06/29/2010 |
| 7598380 | Method of preparation of azaindole derivatives A method of preparing azaindole compounds for antiviral use having the formula ... | 10/06/2009 |
| 7459557 | Substituted isoindole-1,3-diones The present invention relates to substituted isoindole-1,3-dione compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of beni... | 12/02/2008 |
| 7417046 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. ... | 08/26/2008 |
| 7405217 | N-aroyl piperazine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals. ... | 07/29/2008 |
| 7405210 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, ... | 07/29/2008 |
| 7396830 | Piperazine amidines as antiviral agents This disclosure provides compounds of Formula I as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and a... | 07/08/2008 |
| 7393850 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S. ... | 07/01/2008 |
| 7393851 | Azaindole derivatives as inhibitors of p38 kinase The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through a piperidine or piperazine type linker to another cyclic moiety. ... | 07/01/2008 |
| 7390799 | Apoptosis promoters Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed. ... | 06/24/2008 |
| 7390811 | Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—CH═N... | 06/24/2008 |
| 7371755 | Antiviral agents This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties. ... | 05/13/2008 |
| 7365200 | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory fac... | 04/29/2008 |
| 7361760 | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: | 04/22/2008 |
| 7358249 | Heterocyclic compounds having inhibitory activity against HIV integrase A heterocyclic compound of the formula (I): wherein B1 is —C(R2)═ or —N═; R1′ is H, etc.; one of R1 and R2 is -Z1-Z2-Z3-R | 04/15/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7354924 | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral acti... | 04/08/2008 |
| 7351704 | Indazole-carboxamide compounds as 5-HTreceptor agonists The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 recep... | 04/01/2008 |
| 7351708 | Pyrrolo [2,3-b] pyridine derivatives The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the tr... | 04/01/2008 |
| 7348323 | Pyrrolo [2,3-c] pyridine derivatives The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the tr... | 03/25/2008 |
| 7309703 | Substituted pyrazoles Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described. ... | 12/18/2007 |
| 7297792 | Pyrazolopyridines and pyrazolopyridazines as antidiabetics The present invention includes compound of formula (I), or a derivative thereof, wherein Y is CH or N; R1 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substitut... | 11/20/2007 |
| 7259165 | Heterocyclyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 08/21/2007 |
| 7230099 | Heterocyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 and R10, W and Y are... | 06/12/2007 |
| 7220748 | Use of 4-(2-Flurophenyl)-6-methyl-2-(1-piperazinyl)thieno(2,3-D)-pyrimidine for treating of urinary incontinence 4-(2-Fluorophenyl)-6-Methyl-2-(1-Piperazinyl)-Thieno(2,3-D)pyrimidine or a salt thereof is useful for the treatment of urinary incontinence. ... | 05/22/2007 |
| 7189727 | Guanidino compounds Compounds having the general structure III are provided: where D is N or C; W is selected from Z1, Z2, and Z3 are independen... | 03/13/2007 |
| 7186724 | Heterocyclic substituted carbonyl derivatives and their use as dopamine Dreceptor ligands The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine... | 03/06/2007 |
| 7186716 | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors Compounds of Formula I are useful as mediators of protein kinases and have activity as cell proliferation inhibitors: where X, R1–R7 and R9 are as defined herein. ... | 03/06/2007 |
| 7183284 | Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with new aminium salts of 1,2,3-triazoles which can be used as prodrugs to improve the solubi... | 02/27/2007 |
| 7179811 | Respiratory syncytial virus replication inhibitors This invention concerns compounds of formula (I) prodrugs, addition salts, or stereochemically isomeric forms thereof for use as, inter alia, respiratory syncytial virus replication inhibitors; their preparation, c... | 02/20/2007 |
| 7176313 | Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient An anti acid-fast bacterial agent containing, as an active ingredient, a pyridonecarboxylic acid derivative represented by the following general formula (1), a salt thereof, or a hydrate thereof, which shows excellent antibacterial activity against Mycobacterium ... | 02/13/2007 |
| 7163948 | Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs The present invention relates to 1,4-dihydro-4-oxo-1,8-napthpyridine analogs of the formula and pharmaceutically acceptable salts, esters, and prodrugs thereof, wherein A, X, W and Y are ... | 01/16/2007 |
| 7160888 | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and i... | 01/09/2007 |
| 7135469 | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors The present application describes linear chain substituted monocyclic and bicyclic compounds and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof, P-M are rings substituted by a ... | 11/14/2006 |
| 7125888 | Tyrosine kinase inhibitors The present invention relates to imidazopyridine compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, ... | 10/24/2006 |
| 7109196 | 1,8 Naphthyridine derivatives and their use to treat diabetes and related disorders The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the inventio... | 09/19/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
