Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 7932388 | Isotopically enriched N-substituted piperazines and methods for the preparation thereof In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines. ... | 04/26/2011 |
| 7829711 | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-C]pyridine-3-yl]-ethane-1,2-dione The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical composition... | 11/09/2010 |
| 7825247 | N-phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 11/02/2010 |
| 7750156 | Method of producing aminophenol compounds The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a method of producing an aminophenol... | 07/06/2010 |
| 7723519 | Hybrid 2-aminoterailin and aryl-substituted piperazine compounds and their use in altering CNS activity Hybrid compounds containing an aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially hig... | 05/25/2010 |
| 7718802 | Substituted melanocortin receptor-specific piperazine compounds Melanocortin receptor-specific compounds of the general formulas and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, L is a linker, W is a heteroat... | 05/18/2010 |
| 7659395 | Urea derivatives as calcium channel blockers Urea derivatives which comprise compounds of the formula wherein A is H, B is piperidine and each Ar is phenyl are disclosed as useful in treating conditions such as pain, epilepsy, diabetes or prostate cancer. ... | 02/09/2010 |
| 7649092 | Urea derivatives as calcium channel blockers Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity. ... | 01/19/2010 |
| 7605261 | Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use The invention relates to new products of formula (I): in which: Y represents oxygen or sulphur, Z represents C═CH2, CH—CH3 or CH2, R1 represents hydrogen, morpholinyl or the | 10/20/2009 |
| 7605259 | Structurally rigid dopamine d3 receptor selective ligands and process for making them A family of structurally rigid dopamine D3 receptor selective ligands is described. The family of structurally rigid dopamine D3 receptor selective ligands has the formula wherein A is cis or trans —CH═CH—, —C═C—, or cyclohexyl. B is cis or trans —CH... | 10/20/2009 |
| 7605260 | Process for producing imide compound The present invention provides an excellent industrial process for producing an imide compound hydrochloride. The process for producing an imide compound hydrochloride of the formula (2): or an enantiomer thereof, | 10/20/2009 |
| 7569690 | Process for producing oxycarbonyl-substituted piperazine derivative If an organic solvent with a water content of 15% or less is used when an oxycarbonyl-substituted piperazine derivative is produced from a piperazine derivative, the piperazine derivative can be oxycarbonylated. ... | 08/04/2009 |
| 7534886 | Fluorine-containing amide compound and method for preparing the same A fluorine-containing amide compound represented by the following formula (1): wherein Rf is a divalent perfluoropolyether group, and each of R1 and R2 is a substituted or unsubstituted diva... | 05/19/2009 |
| 7507823 | Process of making aripiprazole particles A method of preparation of crystalline aripiprazole monohydrate includes the use of solution enhanced dispersion by supercritical fluid. Specifically, water is introduced to a stream of supercritical fluid which is then allowed to mix with a stream including a mixtu... | 03/24/2009 |
| 7468437 | Phenyl pyrrolidine ether tachykinin receptor antagonists The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations... | 12/23/2008 |
| 7456283 | N-phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 11/25/2008 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7425572 | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions of one or more of... | 09/16/2008 |
| 7423147 | Pyridine compounds as histamine H3 modulators Certain non-imidazole heterocyclic compounds are Histamine H3 modulators in the treatment of Histamine H3 receptor mediated diseases. ... | 09/09/2008 |
| 7423149 | Substituted n-aryl amidines as selective D dopamine receptor antagonists for the treatment of obesity and CNS disorders The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 receptor antag... | 09/09/2008 |
| 7417042 | Compounds for enzyme inhibition Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited b... | 08/26/2008 |
| 7417045 | Heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prod rug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general ... | 08/26/2008 |
| 7414054 | 3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 08/19/2008 |
| 7414067 | Ophthalmic compositions for treating ocular hypertension This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such co... | 08/19/2008 |
| 7405262 | Preparation of functionalized anionic polymerization initiators A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound. ... | 07/29/2008 |
| 7393978 | Method for producing ethylene-amines Process for the preparation of ethylenamines, in particular diethylenetriamine (DETA), by continuous reaction of ethylenediamine (EDA) in the presence of a heterogeneous catalyst, where the reaction is carried out in a reaction column. ... | 07/01/2008 |
| 7393849 | Substituted sulfonamides and ureas useful for inhibiting kinase activity Sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formul... | 07/01/2008 |
| 7388026 | Prodrugs of CC-1065 analogs Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the pr... | 06/17/2008 |
| 7381727 | Pyrrole derivatives, their preparation and their therapeutic use The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The in... | 06/03/2008 |
| 7381821 | Piperazine derivatives and their use as synthesis intermediates The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically... | 06/03/2008 |
| 7371777 | Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ... | 05/13/2008 |
| 7371743 | Carboxylic acid amides, the preparation thereof and their use as medicaments The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers,... | 05/13/2008 |
| 7345168 | Process for the preparation of polyphosphates of organic bases A simple and economical process for the preparation of polyphosphates of organic bases consists of reacting a mixture of phosphorus pentoxide and at least one organic nitrogen base with at least one compound which releases water accompanied by decomposition under th... | 03/18/2008 |
| 7332495 | Aralkyl-ketone piperazine derivatives and their uses as new antalgic or ataractic agent Arylalkyl ketone piperazine derivatives of the formula: and pharmaceutical compositions comprising the same. Also disclosed are methods for using the compounds as analgesic and sedative agents. The compounds of t... | 02/19/2008 |
| 7326710 | Aralkyl formyl-alkyl piperazine derivatives and their uses as a cerebral nerve protective agent Aralkyl formyl alkyl piperazine derivatives Pharmaceutical compositions comprising the same, and methods of using them as a neuroprotective agent. Pharmaceutical results indicate that these compounds have excelle... | 02/05/2008 |
| 7321041 | 1,6 Naphthyridines useful as inhibitors of SYK kinase Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating disease... | 01/22/2008 |
| 7320978 | Oxazole derivatives, preparation and therapeutic use thereof This invention relates to compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as described herein. The i... | 01/22/2008 |
| 7317010 | Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R1, R2, R4, R5, R6, R6a, R7, R8, A and ... | 01/08/2008 |
| 7317101 | Antibacterial cephalosporins A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent. ... | 01/08/2008 |
| 7307169 | Isotopically enriched N-substituted piperazines and methods for the preparation thereof In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines. ... | 12/11/2007 |
