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| Number | Title | Issue Date |
| 5414010 | Dimeric benzimidazoles as central nervous system agents Dimeric benzimidazoles are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as antipsychotic agents and for the treatment of disorders w... | 05/09/1995 |
| 5413999 | HIV protease inhibitors useful for the treatment of AIDS Compounds of formula ##STR1## where R1 and R2 are independently hydrogen or optionally-substituted C1-4 alkyl or aryl, or R1 and R2 are joined together to form a monocyclic or bicyclic ring syste... | 05/09/1995 |
| 5410057 | 1-heteroarylazetidines and -pyrrolidines The present invention relates to new 1-heteroarylazetidines and new 1-heteroarylpyrrolidines endowed with 5-HT3 agonist activity of formula (IV): ##STR1## The substituents A, R', R1 and P, and the variables n and m, are as ... | 04/25/1995 |
| 5403845 | Muscarinic agonists Substituted 1,4,5,6 -tetrahydropyrimidine compositions, substituted 1,2,3,6 -tetrahydropyrimidine compositions and substituted 3,4,5,6 -tetrahydropyridine compositions are disclosed. They are useful for stimulating muscarinic receptors including, for exam... | 04/04/1995 |
| 5399558 | Isoflavonoid antibacterial compounds, compositions and use Methods, compounds and compositions are provided for inhibiting the growth of mycobacteria and gram-positive organisms in vitro and of treatment of mycobacterial and gram-positive infections in vivo using compounds of the formula (I) or (II): ##STR1#... | 03/21/1995 |
| 5399689 | Chlorophenylalkoxyalkyl compounds The present invention is concerned with novel chlorophenylalkoxyalkyl compounds of the general formula ##STR1## wherein R denotes an alkyl residue with 1 to 12 carbon atoms; n is a whole number of 2 to 7, ring A denotes trans-1,4-cyclohexylene or 1,4... | 03/21/1995 |
| 5393889 | Water soluble bis-dioxopiperazine derivatives A pharmaceutically-acceptable acid addition salt of a bis-dioxopiperazine derivative of the formula (I): ##STR1## which derivative exhibits anti-tumor potency and is water-soluble, wherein R1 is a C1-6 alkyl group, R2... | 02/28/1995 |
| 5385904 | Organic salts of N,N'-diacetyl cystine New crystalline organic salts of N,N'-diacetyl cystine with immunomodulating effect, processes for their preparation, pharmaceutical compositions containing them and methods of their pharmacological use.... | 01/31/1995 |
| 5384319 | Aminoalkylphenyl compounds Aminoalkylphenyl derivatives of formula I ##STR1## wherein alk, R1 -R6, X and Y are as defined in the description, and salts thereof, exhibit properties inhibiting the biosynthesis of interleukin-1 (IL-1) and analgesic propertie... | 01/24/1995 |
| 5382583 | Piperazine derivatives Piperazine derivatives of formula: ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula, n is 1 or 2; R and R5 are hydrogen or lower alkyl, R1 is substituted or unsubstituted aryl or a... | 01/17/1995 |
| 5380844 | Nitrogen-containing perfluoroalkanoyl peroxide and method for production thereof A nitrogen-containing perfluoroalkanoyl peroxide is provided which is represented by the formula: ##STR1## wherein Rf1 and Rf2 independently stand for an alkyl group of 1 to 5 carbon atoms, provided that Rf1 and Rf | 01/10/1995 |
| 5364924 | Substituted ureas containing cyclic amines as chain extenders in polymeric systems Diamino ureas having the formula ##STR1## wherein each ring is saturated and includes 3-5 carbon atoms and n alkyl substituents R of 1-4 carbon atoms each and n for each ring is 1-4, a method of using these materials as chain extending agents in the ... | 11/15/1994 |
| 5354500 | Optically active carboxylic esters of oxygen-containing heterocycles as doping substances in liquid crystal mixtures and liquid crystal mixtures containing them Use of optically active carboxylic esters of oxygen-containing heterocycles as doping substances in liquid crystal mixtures and liquid crystal mixtures containing them. Optically active 1,3-dioxolane-4-carboxylic esters and oxirane-2-carboxylic esters of ... | 10/11/1994 |
| 5348955 | N,N-diacylpiperazines Diacylpiperazines of general structural formula: ##STR1## are: angiotensin II (A-II) antagonists with affinity for both AT1 and AT2 receptors useful in the treatment of hypertension, congestive heat failure, cerebrovascular, cog... | 09/20/1994 |
| 5346902 | Fungicidal diazinyl dioxime Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein Y is a specified small group or single atom and R1 and R2 are selected from a wide range of specified substituents.... | 09/13/1994 |
| 5346896 | 1-(aryl or heteroaryl)-4[ω-(aryl or heteroaryl)ω-(aryl or heteroaryl)alkylene]piperazines Disclosed herein are piperazine derivatives of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein W is (CH2)m, CHOH or O, m is one of the integers 1 or 2, A is an alkylene chain of 1 to 3 carbon... | 09/13/1994 |
| 5344830 | N,N-diacylpiperazine tachykinin antagonists Diacylpiperazines of general structure ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma, and calcium channel blockers useful in the treatment of cardiovascular conditions such... | 09/06/1994 |
| 5342837 | Fungicides dizinyl oxime ethers Fungicidal compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl... | 08/30/1994 |
| 5340822 | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present The invention relates to polycyclic amine compounds of formula (I) ##STR1## where Y. m. Ar', n, p, Q, T, q and Z are defined herein. The invention also relates to methods of making the compounds of formula (I) and pharmaceutical compositions which co... | 08/23/1994 |
| 5340812 | Piperazine derivatives Piperazine derivatives of formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R1 is an aryl or nitrogen containing heteroaryl radical, R2 | 08/23/1994 |
| 5332816 | Piperazine-piperidine compounds for use as stabilizers for organic materials The present invention relates to novel piperazine-piperidine compounds of the general formula (I) ##STR1## in which R1 is e.g. hydrogen or methyl, R2 is e.g. ethylene, m is zero or 1 and n is e.g. 1, and when n is 1, A is e.g. ... | 07/26/1994 |
| 5332732 | Thiophene and pyridine antipsychotic agents Compounds of the general formula I ##STR1## wherein A is N; Ar is aryl, substituted aryl or benzofuranyl, wherein the substituents are selected from C1 -C8 alkoxy; B is CO or CH2 and HET is selected from any of piperi... | 07/26/1994 |
| 5328916 | Heterocyclic compounds useful for inhibition of renin New heterocyclic compounds of the formula X--W--CR1 R2 --CO--Y--NR3 --CHR4 --CR5 --CH2 --(CR6 R7)r --Z--Het I in which R1 to R7 | 07/12/1994 |
| 5326783 | Cholesterol lowering compounds This invention is directed to compounds of formula (I) which are novel C3- or C5-acyl sulfonamide, carboxamic acid or tetrazolyl analogs of the Zaragozic acids. These compounds inhibit the enzyme squalene synthase and are useful as cholesterol lowering ag... | 07/05/1994 |
| 5314889 | Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them A 2-Acylaminothiazole of formula: ##STR1## in which R1 is H, an alkyl or a substituted alkyl; RIV is a cycloalkyl, an aromatic group such as phenyl or a heterocyclic group which are unsubstituted or substituted; RV is... | 05/24/1994 |
| 5314887 | 2-amino-1, 4-dihydropyridine derivatives with calcium agonist and alpha.sub. -antagonist activity There are provided novel 1,4-dihydropyridine compounds possessing both calcium agonist and alpha1 -antagonist activity useful for treating congestive heart failure, pharmaceutical compositions containing them and methods of using these compound... | 05/24/1994 |
| 5310767 | Tetramethylpiperidine compounds for use as stabilizers for organic materials The present invention relates to novel tetramethylpiperidine compounds of the formula (I) ##STR1## in which R1 is e.g. hydrogen or methyl, R2 and R3 are e.g. --(CH2)2 --, R4 is e.g. --... | 05/10/1994 |
| 5306728 | Substituted amine derivatives having antihyperlipemia activity Substituted amine derivatives represented by the general formula ##STR1## wherein Q is -C-D-E- F-G-M- or -N-H-I-J-K-L- [C, D, E, F, G, H, I, J, K and L are each O, S, a carbonyl group, -CHR2 -, -Rb = or -NRc - (R... | 04/26/1994 |
| 5306719 | Carbostyril derivatives and salts thereof Novel carbostyril derivatives and salts thereof having useful pharmacological activities such as myocardial contraction increasing activity (positive inotropic activity), coronary blood flow increasing activity, hypotensive activity, activity for inhibiti... | 04/26/1994 |
| 5300647 | O-carbonyl N-hydroxy hindered amine stabilizers Hindered amines based on various 2,2,6,6-tetraalkylated nitrogen-containing heterocyclic moieties wherein the hindered nitrogen atom on the ring is substituted with O-acyl, O-carbamoyl or O-carbonate substituents and the 4-position of the ring is substitu... | 04/05/1994 |
| 5300643 | Quinolonecarboxylic acid derivatives New quinolone-carboxylic acids of the general formula (I) ##STR1## wherein the definitions for R1 -R9 are given in the description, a process for their preparation and their use as medicaments, in particular as antiviral agents.... | 04/05/1994 |
| 5300642 | , -disubstituted aromatics and heteroaromatics as cognition enhancers Cognitive defeciencies or neurological dysfunction in mammals are treated with ,-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: ##STR1## or a salt thereof wherein X and Y are taken together to form a... | 04/05/1994 |
| 5300584 | Low viscosity diprimary amine reactive modifiers for epoxy resins A low viscosity, diprimary amine-terminated reactive liquid polymer with low residual amine content, comprising the reaction product of a diprimary amine having the following formula H2 N--R--NH2 wherein --NH2 is a primary term... | 04/05/1994 |
| 5292726 | N,N-diacylpiperazines Diacylpiperazines of general structure ##STR1## are: angiotensin II (A-II) antagonists selective for the type 2 (AT2) subtype useful in the treatment of cerebrovascular, cognitive, and CNS disorders; tachykinin receptor antagonists useful ... | 03/08/1994 |
| 5286728 | Amino-substituted piperazine derivatives Amino-substituted piperazine derivatives of formula I ##STR1## wherein R1 -R6, X and Y are as defined in the description, and salts thereof, have properties inhibiting the biosynthesis of interleukin-1 (IL-1) as well as analgesi... | 02/15/1994 |
| 5266699 | NIR dyes, methods of preparing them and their use The compounds of the formula I ##STR1## in which Y and Y1 are each, independently of one another, O, S, NH or N-alkyl, N-cycloalkyl, N-phenyl or N-benzyl, or Y and Y1 are together N-alkylene-N, R and R1 are each, independe... | 11/30/1993 |
| 5256786 | Catalytic reforming of cyclic alkyleneamines A process of reforming cyclic alkyleneamines to amine-extended cyclic alkyleneamines involving contacting a cyclic alkyleneamine or mixture of cyclic alkyleneamines in the liquid phase with a catalyst under reaction conditions. The catalyst is selected fr... | 10/26/1993 |
| 5256785 | Smoking compositions containing an oxalate flavorant-release additive In one embodiment this invention provides smoking compositions which contain a novel oxalate ester flavorant-release additive. Under cigarette smoking conditions, a combustible filler additive such as methyl 2-pyrazinyl-2-propanyl oxalate or di(2-pyrazinyl-2-p... | 10/26/1993 |
| 5250528 | New aminopiperazine derivatives This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity and represented by the general formula [I]: ##STR1## wherein R1 is lower alkyl, aryl, ar(lower)alkoxy or a heterocyclic grou... | 10/05/1993 |
| 5247087 | Epoxy modified water clarifiers Dithiocarbamic salts made from the reaction products of certain polyamines and epoxides have been found to be useful to clarify water, particularly the oil-in-water emulsions which accompany crude oil production. The water clarification may be accomplishe... | 09/21/1993 |
