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| Number | Title | Issue Date |
| 7229998 | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors The present invention provides a compound of formula (I): wherein R1–R5, R25, R26, Y and X2 are as defined herein. The compounds a... | 06/12/2007 |
| 7205330 | Inhibitors of hepatitis C virus NS3 protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 04/17/2007 |
| 7196080 | Phenylpyridinecarbonylpiperazinederivative The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein ... | 03/27/2007 |
| 7192960 | Sodium channel blockers The present invention relates to a compound represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): ... | 03/20/2007 |
| 7192958 | Sodium channel blockers The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): ... | 03/20/2007 |
| 7186715 | Piperazine- and piperidine-derivatives as melanocortin receptor agonists The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction ... | 03/06/2007 |
| 7176311 | Process for preparing pharmaceutically active compounds A process for the preparation of Compounds of the formula (1): wherein R1, R2, R4 and R13 are as defined or a pharmaceutically or veterinarily acceptable salt or polymo... | 02/13/2007 |
| 7173035 | Arylsulfonamide compounds The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II... | 02/06/2007 |
| 7173034 | Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein -a1=a2-a3=a4- is a radical of for CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—CH═N— wherein each ... | 02/06/2007 |
| 7163948 | Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs The present invention relates to 1,4-dihydro-4-oxo-1,8-napthpyridine analogs of the formula and pharmaceutically acceptable salts, esters, and prodrugs thereof, wherein A, X, W and Y are ... | 01/16/2007 |
| 7157462 | Therapeutic agents useful for treating pain A compound of formula: wherein Ar, Ar1, Ar2, R3–R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopip... | 01/02/2007 |
| 7157464 | Substituted piperazines Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful ... | 01/02/2007 |
| 7153858 | Arylpiperazinyl compounds The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formulae I: and II, and synthesis and uses of those compounds for treating diseases including those mediated directly or indirectly by 5-HT rec... | 12/26/2006 |
| 7153856 | Cyclic protein tyrosine kinase inhibitors Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders. ... | 12/26/2006 |
| 7129354 | Process for the preparation of stable acid addition salt of 2,3-disubstituted pyrazine compounds The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): | 10/31/2006 |
| 7122551 | Metalloproteinase inhibitor compounds Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13. ... | 10/17/2006 |
| 7119203 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop... | 10/10/2006 |
| 7119086 | Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopress... | 10/10/2006 |
| 7109259 | Piperazinone derivatives A compound of the formula (I) wherein n is preferably 3; G1, G2, G3 and G4 are independently of one another e.g. C | 09/19/2006 |
| 7109200 | Carbamate derivatives, process for producing the same and use thereof Novel carbamate derivatives which are useful as drugs because of inhibiting activated blood coagulation factor X and thus exerting an anticoagulant effect. Compounds represented by the formula: wherein R1 | 09/19/2006 |
| 7105519 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: ... | 09/12/2006 |
| 7101886 | Phenylalkyl and pyridylalkyl piperazine derivatives This invention relates to compounds of the formula 1 wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containi... | 09/05/2006 |
| 7094779 | Piperazine oxime dervatives having NK-1 receptor antagonistic activity The present invention relates to a group of novel piperazine oxime derivatives having interesting NK-1 antagonistic activity. The invention relates to compounds of the general formula (1) wherein: X represents phenyl or pyridyl substituted with 1 or 2 substituents f... | 08/22/2006 |
| 7091199 | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d antagonists The compounds are of the class of thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These condi... | 08/15/2006 |
| 7071180 | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2... | 07/04/2006 |
| 7071182 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in repro... | 07/04/2006 |
| 7064118 | Heteroaryl diazacycloalkanes, their preparation and use The present invention relates to novel heteroaryl diazacycloalkane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of... | 06/20/2006 |
| 7049460 | Selective inhibitors of the urokinase plasminogen activator The present invention relates to novel selective inhibitors of the urokinase plasminogene activator (uPA, EC 3.4.21.31) of the aryl guanidine type. ... | 05/23/2006 |
| 7026314 | Therapeutic chromone compounds Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sleep disorders. The compounds ... | 04/11/2006 |
| 7015325 | Tryptase inhibitors Compounds of the formula (I), in which M, A1, A2, K1 and K2 have the meanings indicated in the description are novel active tryptase inhibitors. ... | 03/21/2006 |
| 7008946 | CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13 ... | 03/07/2006 |
| 6995156 | Platelet adenosine diphosphate receptor antagonists Compounds of the following formula (I): where a, b, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmace... | 02/07/2006 |
| 6995161 | Substituted arylpyrazines Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affinity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases as... | 02/07/2006 |
| 6995151 | Isophthalic acid derivatives as matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1 | 02/07/2006 |
| 6992086 | Antagonists of MCP-1 function and methods of use thereof The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifica... | 01/31/2006 |
| 6979738 | Quadruplex stabilizer This invention relates to carbazole compounds of the following formula: In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is... | 12/27/2005 |
| 6972289 | Cell division inhibitor and a production method thereof The present invention relates to a cell division inhibitor comprising various dehydrodiketopiperazines such as dehydrophenylahistin, or analogs thereof as an active ingredient, and a dehydrogenase and a method for producing the same inhibitor. ... | 12/06/2005 |
| 6969713 | Piperidine and piperazine acetamide derivatives The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy | 11/29/2005 |
| 6960474 | Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator Selective androgen receptor modulators (SARMs) having antagonist activity in hormone-dependent tumors while exhibiting no activity or agonist activity against other nontumor tissues containing the androgen receptor as well as methods for identifying, designing and u... | 11/01/2005 |
| 6960580 | Nitrogenous heterocyclic substituted quinoline compounds The present invention relates to nitrogen-containing heterocyclic quinoline compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also r... | 11/01/2005 |
