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| Number | Title | Issue Date |
| 7989622 | Phosphatidylinositol 3-kinase inhibitors and methods of their use The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others.... | 08/02/2011 |
| 7432270 | N-aroyl cyclic amines This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3;... | 10/07/2008 |
| 7429585 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups The present invention relates to compounds of the general formula IC wherein R2, R′, R″, R3, R6, X1 and X1′ are as defined here... | 09/30/2008 |
| 7420056 | Substituted bicyclic imidazo-3-ylamine compounds Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these compounds for the production of pharmaceutical formulations and related metho... | 09/02/2008 |
| 7279493 | Therapeutic agents useful for treating pain A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an ef... | 10/09/2007 |
| 7279475 | Fluorinated di-aryl urea compounds Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus... | 10/09/2007 |
| 7273863 | Benzophenones as inhibitors of reverse transcriptase The present invention includes benzophenone compounds (I) which are useful in the treatment of HIV infections. ... | 09/25/2007 |
| 7262194 | Therapeutic agents useful for treating pain A compound of formula: wherein X is S or O and A, R1-R4, n, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Pyridazinylpiperazine Compound”), compositions c... | 08/28/2007 |
| 7241761 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups The present invention relates to compounds of the general formula I wherein R1 is the group and R2, R′, R″, R3... | 07/10/2007 |
| 7157462 | Therapeutic agents useful for treating pain A compound of formula: wherein Ar, Ar1, Ar2, R3–R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopip... | 01/02/2007 |
| 7071192 | Respiratory syncytial virus replication inhibitors The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a1=a2-a3=a4-represents a radical of formu... | 07/04/2006 |
| 7030125 | Isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of... | 04/18/2006 |
| 6972290 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory... | 12/06/2005 |
| 6969713 | Piperidine and piperazine acetamide derivatives The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy | 11/29/2005 |
| 6927214 | Non-peptide GLP-1 agonists Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an activation of... | 08/09/2005 |
| 6890926 | Heteroaryl derivatives and their use as medicaments The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors. ... | 05/10/2005 |
| 6858611 | Potassium channel inhibitors Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described. ... | 02/22/2005 |
| 6852712 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a pati... | 02/08/2005 |
| 6821967 | Substituted piperazine derivatives, the preparation thereof and their use as medicaments The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, ... | 11/23/2004 |
| 6723730 | Capsaicin receptor ligands Disclosed are diaryl piperazines and related compounds of the following Formula: wherein the variables are as defined in the specification. These compounds are selective modulators of capsaicin receptors, including human... | 04/20/2004 |
| 6683184 | Piperazine derivatives and process for the preparation thereof The present invention relates to a novel compound of formula (I) and its pharmaceutically acceptable acid addition salt, and process for the preparation thereof, which have strong antitumor activities and very low toxicity: ##STR1## wherein R | 01/27/2004 |
| 6620849 | Potassium channel inhibitors Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.... | 09/16/2003 |
| 6602863 | Irreversible inhibitors of tyrosine kinases The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compou... | 08/05/2003 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6548499 | Substituted quinoxaline derivatives as interleukin-8 receptor antagonists Quinoxaline compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in the treatment of a chemokine-mediated disease wherein the ... | 04/15/2003 |
| 6545155 | Fused heteroaromatic glucokinase activators Glucokinase activating amides useful for increasing insulin secretion in the treatment of type II diabetes are disclosed.... | 04/08/2003 |
| 6524347 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treatin... | 02/25/2003 |
| 6525054 | Cyanoiminoquinoxaline derivatives A cyanoiminoquinoxaline derivative of the formula (II) is useful as a preventive or therapeutic agent for diseases due to hyperexcitation of glutamate receptors. ##STR1## (wherein, X and Y each is independently O or NCN, provided that at least one of... | 02/25/2003 |
| 6482949 | Colormetric sensor compositions and methods The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as w... | 11/19/2002 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6448244 | Water soluble azoles as broad-spectrum antifungals The present invention concerns novel water-soluble azole compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof; as antifungals; their processes for preparation... | 09/10/2002 |
| 6391878 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists This invention involves compounds having the following structure: ##STR1## as described in the Claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmac... | 05/21/2002 |
| 6384224 | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof, wherein: X, Y and Z are the same or different and represent optionally substituted carbon or nitrogen; R1 and R2 independently represe... | 05/07/2002 |
| 6288082 | Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1## wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as... | 09/11/2001 |
| 6245760 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for trea... | 06/12/2001 |
| 6180632 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for trea... | 01/30/2001 |
| 6166205 | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: Ra represents ##STR2## where X, Y and Z are the same or different and represent CH or nitrogen; R1 R | 12/26/2000 |
| 6166041 | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH2 --CH2 --, --CH2 --, a single or ... | 12/26/2000 |
| 6162803 | Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression Compounds effective in treating disorders of the serotonin-affected neurological symptoms are provided, such compounds having the following formula: ##STR1## wherein: R1 and R5 are each, independently, hydrogen, halogen, lo... | 12/19/2000 |
| 6159978 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treatin... | 12/12/2000 |
