Did You Know...
...that on Dec. 15, 1836, the Patent Office was completely destroyed by fire? Lost were some 7,000 models, 9,000 drawings, and 230 books plus all records of patent applications and grants.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8030489 | Ornithine derivative Provided is a compound which is useful as a therapeutic agent for chronic renal insufficiency and a therapeutic agent for diabetic nephropathy. The present inventors have made extensive studies on an ornithine derivative having an antagonistic action against ... | 10/04/2011 |
| 7968713 | Method of synthesizing quinoxaline derivative by microwave irradiation There is disclosed a method of synthesizing a quinoxaline derivative in which toxicity, corrosiveness and permeation are low and which is excellent in safety and which attains a reduced reaction time, a greatly improved yield and excellent economical efficiency. The... | 06/28/2011 |
| 7947834 | Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators The present invention is related to a compound of formula (I): wherein i, j, n, o, p, q, r, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R | 05/24/2011 |
| 7432270 | N-aroyl cyclic amines This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3;... | 10/07/2008 |
| 7405217 | N-aroyl piperazine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals. ... | 07/29/2008 |
| 7399884 | Histone deacetylase inhibitors Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consist... | 07/15/2008 |
| 7378448 | Diphenylether amide derivatives as opioid receptor antagonists A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3′, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mi... | 05/27/2008 |
| 7348324 | Cyclic amine compounds as CCR5 antagonists A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic ... | 03/25/2008 |
| 7294716 | Process for preparing isomerically pure prodrugs of proton pump inhibitors Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description. ... | 11/13/2007 |
| 7253168 | Substituted 1-benzyl-4-substituted piperazine analogues Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment... | 08/07/2007 |
| 7241745 | Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds as well as their m... | 07/10/2007 |
| 7173027 | Receptor selective cannabimimetic aminoalkylindoles Disclosed are cannabimimetic aminoalkylindole compounds and methos for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoinds. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compoun... | 02/06/2007 |
| 7154002 | Histone deacetylase inhibitors Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each ... | 12/26/2006 |
| 7132418 | Peptidyl heterocyclic ketones useful as tryptase inhibitors The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particul... | 11/07/2006 |
| 7101886 | Phenylalkyl and pyridylalkyl piperazine derivatives This invention relates to compounds of the formula 1 wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containi... | 09/05/2006 |
| 7094919 | Preparation of substituted aromatic carboxylic acid esters Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: Additionally the inventio... | 08/22/2006 |
| 7034049 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3–C6 cycloalkyl group optionally substituted by a straight or branched C1–C6 alkyl or arylalkyl group; R1 is a straig... | 04/25/2006 |
| 7030125 | Isothiazole and isoxazole compounds as transforming growth factor (TGF) inhibitors Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of... | 04/18/2006 |
| 7019003 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 03/28/2006 |
| 6979737 | Quinoxaline-containing AB monomer for hyperbranched aromatic poly(ether-ketones) A novel AB2 monomer, 2,3-bis(4-phenyloxyphenyl)-6-quinoxaline carboxylic acid. ... | 12/27/2005 |
| 6953800 | Use of selective antagonists of the α1B-adrenergic receptor for improvement of sexual dysfunction Described is the use in the treatment of either male or female sexual dysfunction of selective antagonists of the α1B-adrenergic receptor and the pharmaceutical compositions containing them as compounds capable of helping the sexual act avoiding at the s... | 10/11/2005 |
| 6927214 | Non-peptide GLP-1 agonists Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an activation of... | 08/09/2005 |
| 6916803 | 3-(Heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents The present invention relates to novel Syn isomers of racemates and optical isomers of 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids of the following formula: and their use in treating infections caused by ... | 07/12/2005 |
| 6914160 | Oxytocin inhibitors This invention relates to compounds of formula (I) ... | 07/05/2005 |
| 6878706 | Cyanamides useful as reversible inhibitors of cysteine proteases Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B... | 04/12/2005 |
| 6858744 | Dihydoxyhexanoic acid derivatives, their intermediates, and methods of making This invention relates to dihydroxyhexanoic acid derivatives and their intermediates, as well as to methods of preparing such compounds. Additionally, present invention relates to removing a protecting group from a protected amine wherein the method comprises reacti... | 02/22/2005 |
| 6750344 | Amine compounds and combinatorial libraries comprising same The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with build... | 06/15/2004 |
| 6723730 | Capsaicin receptor ligands Disclosed are diaryl piperazines and related compounds of the following Formula: wherein the variables are as defined in the specification. These compounds are selective modulators of capsaicin receptors, including human... | 04/20/2004 |
| 6713472 | Thiazine or pyrazine derivatives A compound which is a chymase inhibitor and which is represented by a formula [I] and salts thereof. In the formula [I], X is R6—(A2)n—N, R1 and R2 are H, alkyl, cycloalkyl or aryl, R3 and R4... | 03/30/2004 |
| 6689886 | Quinoxalinyl carboxylic acid derivatives A compound of the formula XXXI ##STR1## or the pharmaceutically acceptable salt thereof; wherein R1, R2, and R3 are as defined herein and the compound is useful in the preparation or use of compounds that treat inflammatio... | 02/10/2004 |
| 6673801 | Dihydroxyhexanoic acid derivatives Dihydroxyhexanoic acid derivatives of the general formula ##STR1## are useful to treat inflammation and other immune disorders.... | 01/06/2004 |
| 6573268 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically accep... | 06/03/2003 |
| 6548671 | Quinoxalinyl amide derivatives A compound of the formula ##STR1## or the pharmaceutically acceptable salt thereof; wherein R1, R2, R3 and R4 are as defined above useful to treat inflammation and other immune disorders.... | 04/15/2003 |
| 6531474 | Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1ଲ converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The c... | 03/11/2003 |
| 6521621 | 1-(1,2-disubstituted piperidinyl)-4-substituted piperazine derivatives This invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; p is 1 or 2; .dbd.... | 02/18/2003 |
| 6495547 | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties The present invention of compounds of formula (I) ##STR1## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk1 is C1-6 alkanediyl optionally subs... | 12/17/2002 |
| 6495551 | Substituted phenyloxazolidinones and their use as antibiotics The invention concerns compounds of formula (I), ##STR1## wherein, for example, R1 is of the formula --NHC(.dbd.O)Ra wherein Ra is (1-4C)alkyl; R2 and R3 are independently hydrogen or fluoro; R5... | 12/17/2002 |
| 6492553 | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.... | 12/10/2002 |
| 6482949 | Colormetric sensor compositions and methods The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as w... | 11/19/2002 |
| 6472404 | HIV protease inhibitors The present invention discloses novel isoquinoline carboxamide derivatives which are HIV protease inhibitors or prodrugs thereof, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the co... | 10/29/2002 |
