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| Number | Title | Issue Date |
| 7432267 | Fused cyclic modulators of nuclear hormone receptor function Disclosed are compounds having the formula (I): including compounds of formulae (Ia) and (Ib): wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker,... | 10/07/2008 |
| 7420056 | Substituted bicyclic imidazo-3-ylamine compounds Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these compounds for the production of pharmaceutical formulations and related metho... | 09/02/2008 |
| 7268215 | Photoprotein derived from okinawan squid and gene encoding the photoprotein By using a bioluminescence, a method for detection of a monovalent cation is provided and the method is a high sensitive and simple method. According to the present invention, an amino acid sequence of symplectin and a base sequence encoding the protein are provided... | 09/11/2007 |
| 7208494 | 5HT2c receptor agonists The present invention provides piperazine derivatives of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in the desc... | 04/24/2007 |
| 7202245 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines The present invention provides compounds of formula (I) the prodrugs thereof, and the pharmaceutically acceptable salts of the compounds and prodrugs, wherein Ra, Rb, R1, and R | 04/10/2007 |
| 7144887 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y—X where L-Y is a linking portion and X is generally an a... | 12/05/2006 |
| 7109351 | Fused pyrrolecarboxamides; GABA brain receptor ligands Substituted pyrrolecarboxamide compounds are disclosed. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors ... | 09/19/2006 |
| 7098229 | (+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions and uses thereof The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and metho... | 08/29/2006 |
| 7098338 | 2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives This invention provides compounds of formula I, wherein R is hydrogen or alkyl of 1–6 carbon atoms; R′ is hydrogen, alkyl of 1–6 carbon atoms, acyl of 2â€... | 08/29/2006 |
| 7098337 | 1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene and 1,2,3,4-tetrahydro-2,4a,5-triaza-fluorene derivatives The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts, solvates and esters thereof. These compounds can be used to prepare pharmaceutical compositions for the trea... | 08/29/2006 |
| 7060694 | High potency dihydroergotamine compositions The present invention is directed to improved formulations for dihydroergotamine in which the drug is present at a concentration of at least 2.9 mM. The invention encompasses methods for using these formulations in treating patients for migraine headaches and the pa... | 06/13/2006 |
| 6998485 | Polyazido compounds The compound 3a,8a-bis-azidomethyl-3a,4,8a,9-tetrahydro-3H,8H-bis-[1,2,3]triazolo[1,5-a;1″,5″-d]pyrazine, whose structure is depicted below, is disclosed: ... | 02/14/2006 |
| 6967202 | Method of synthesizing diketopiperazines The invention provides a method of synthesizing a diketopiperazine of the formula: wherein: R1 is —CH2COR3, or —CH2CH2COR | 11/22/2005 |
| 6953801 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 10/11/2005 |
| 6933294 | Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, hal... | 08/23/2005 |
| 6869955 | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating anxiety, depression, and other psychiatric and neurological disorders. ... | 03/22/2005 |
| 6759524 | Photoprotein derived from okinawan squid and gene encoding the photoprotein By using a bioluminescence, a method for detection of a monovalent cation is provided and the method is a high sensitive and simple method. According to the present invention, an amino acid sequence of symplectin and a base sequence encoding the protein are provided... | 07/06/2004 |
| 6723721 | CRF receptor antagonists and methods relating thereto Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke. The compounds of this invention have the following structures: ... | 04/20/2004 |
| 6673927 | Farnesyl transferase inhibitors The present invention is directed to compounds of the ##STR1## wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumors and restenosis.... | 01/06/2004 |
| 6653470 | Process for the preparation of 1,4,7,10-tetraazacyclododecane 1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.... | 11/25/2003 |
| 6638934 | Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7 | 10/28/2003 |
| 6630472 | Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic [3.3.1], [4.3.1] or polycyclic az... | 10/07/2003 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6555538 | 5-arylsulfonyl-imidazo[1',2':1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds This application is directed to a compound of Formula I ##STR1## wherein a, X, R1, R2, R3 and R4 are as defined herein, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, infla... | 04/29/2003 |
| 6545149 | Synthesis and crystallization of piperazine ring-containing compounds The present invention is directed to methods for the preparation of piperazine ring-containing compounds, particularly mirtazapine. According to the present invention, the mirtazapine intermediate 1-(3-carboxypyridyl-2)-4-methyl-2-phenyl-piperazine is mad... | 04/08/2003 |
| 6531475 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this in... | 03/11/2003 |
| 6514984 | Treatment for alzheimer's disease A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA2 inhibitor.... | 02/04/2003 |
| 6492364 | Triazolo and derivatives as chemokine inhibitors Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These are useful as therapeutic agents for allergic diseases such... | 12/10/2002 |
| 6489315 | Cyclic compounds, their production and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C | 12/03/2002 |
| 6465465 | Process for the treatment of erectile dysfunction and product therefor The invention relates to the use of pyrido[3,2-e]-pyrazinones of formula 1 as inhibitors of phosphodiesterase 5 for the treatment of erectile dysfunction (impotence).... | 10/15/2002 |
| 6451796 | Fused pyrazine compounds The compound of the formula (I): ##STR1## wherein all the symbols are meaning the same as descriptions of the specification; and salts thereof. The compounds of the formula (I) have inhibitory activity of adhesion molecules expression, and are useful for ... | 09/17/2002 |
| 6423715 | Thiazolobenzoheterocycles, their preparation and medicaments containing them Compounds of formula (I): ##STR1## their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them are discussed.... | 07/23/2002 |
| 6399609 | Therapeutic usage of tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders Corticotropin releasing factor (CRF) antagonists of formula I: ##STR1## and their use in treating anxiety, depression, and other psychiatric and neurological disorders.... | 06/04/2002 |
| 6348466 | CRF receptor antagonists and methods relating thereto Compounds are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, including stroke. The compounds of this invention have the following s... | 02/19/2002 |
| 6251905 | Tricyclic compounds, their production and use Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optiona... | 06/26/2001 |
| 6242437 | Cephem derivatives A compound represented by the following formula (I) is disclosed. This compound has potent antimicrobial activity against a wide spectrum of bacteria from Gram-positive bacteria to Grame-negative bacteria including ଲ-lactamase producing bacteria. In... | 06/05/2001 |
| 6239133 | Imidazoquinoxaline protein tyrosine kinase inhibitors Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.... | 05/29/2001 |
| 6235740 | Imidazoquinoxaline protein tyrosine kinase inhibitors Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.... | 05/22/2001 |
| 6124287 | Imidazo[1,2-a]quinoxalin-4-amines active as adenosine antagonists, process for their preparation and pharmaceutical compositions thereof Imidazo[1,2-a]quinoxalin-4-amines derivatives of formula (I) ##STR1## are described, and salt thereof active as adenosine antagonists and a process for their preparation and pharmaceutical compositions containing them as therapeutically active compou... | 09/26/2000 |
| 6121265 | Heterocyclic substituted imidazoloquinoxalinones, their preparation and their use Imidazoloquinoxalinones of the formula ##STR1## where R1 -R5, A and B have the meanings stated in the description, and their preparation are described. The novel substances are suitable for controlling diseases.... | 09/19/2000 |
