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Actor Marlon Brando has four patents, all named "Drumhead tensioning device and method."
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| Number | Title | Issue Date |
| 8188277 | Aromatic compounds for suppressing the generation of collagen The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general for... | 05/29/2012 |
| 8058437 | (Pyrroloquinoxalinyl) pyrazinecarbohydrazide-oxalic acid co-crystal for treatment of cancer and other diseases A novel co-crystal of N′-(7-fluoropyrrolo[1,2a]quinoxalin-4-yl)pyrazine-2-carbohydrazide with oxalic acid is disclosed. The disclosed oxalic acid co-crystal demonstrates cancer cell growth inhibition and is more bioavailable than the corresponding free base when a... | 11/15/2011 |
| 7807833 | Method for total synthesis of ecteinascidins and intermediate compounds thereof An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2 of N12 site is trichloroethoxicarbonyl (Troc) to which various subs... | 10/05/2010 |
| 7417145 | Process for total synthesis of ecteinascidins and intermediates therefor An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2 of N12 site is trichloroethoxicarbonyl (Troc) to which various subs... | 08/26/2008 |
| 7371861 | Process for preparing ring-fluorinated aromatics The present invention relates to an improved process for preparing ring-fluorinated aromatics of the general formula (I) by a halogen exchange reaction (halex reaction) of a plurality of halogen substituents in one stage in... | 05/13/2008 |
| 7355340 | Quinoxaline derivatives, organic semiconductor device and electroluminescent device The present invention is to provide quinoxaline derivatives, which have excellent electron transportation and hole blocking properties, and which can be formed into a film without being crystallized. According to the invention, quinoxaline derivatives represented by... | 04/08/2008 |
| 7273869 | Inhibitors of Akt activity The present invention is directed to compounds comprising a ring-fused quinoxalinyl moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inven... | 09/25/2007 |
| 7253281 | Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the fo... | 08/07/2007 |
| 7250511 | Process for the preparation of cyclopenta[g]quinazoline derivatives Cyclopenta[g]quinazolines of formula (I), and esters and amides thereof may be made by reacting an ester or amide of formula (II); or a protected derivative thereof with a complex containing the (propargyl)Co2(CO)6+ion | 07/31/2007 |
| 7244843 | Modulators of serotonin receptors The present invention provides modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metab... | 07/17/2007 |
| 7230139 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid... | 06/12/2007 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7217844 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid... | 05/15/2007 |
| 7208490 | Tricyclic tetrahydroquinoline antibacterial agents The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens ... | 04/24/2007 |
| 7189724 | Quinoxaline derivatives having antiviral activity The invention provides substituted quinoxalines having the general formulas where R1, R2, R3, and R4 are, inter alia, alkyl, aryl, or heteroaryl groups; Z is NH or O; a... | 03/13/2007 |
| 7173038 | Quinazoline derivatives as VEGF inhibitors The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C | 02/06/2007 |
| 7160732 | Fluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 01/09/2007 |
| 7153859 | Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceuti... | 12/26/2006 |
| 7145009 | Pirazino(aza)indole derivatives Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous syste... | 12/05/2006 |
| 7041826 | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula I that makes use of a novel piperazine derivative, 4-Benzyl-1-methyl-2-oxo-3-phenylpiper... | 05/09/2006 |
| 7034105 | FLT4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor. ... | 04/25/2006 |
| 6960587 | Condensed pyrazindione derivatives as PDE inhibitors Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 11/01/2005 |
| 6953791 | Dipeptide derivatives This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which inc... | 10/11/2005 |
| 6933387 | Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles The present invention is directed to 1,2,3,4,10,10a-hexahydropyrazino [1,2-a]indole derivatives of formula (I): as well as pharmaceutically acceptable salts, hydrates and esters thereof, wherein the substituents have t... | 08/23/2005 |
| 6930104 | Heterocyclic derivatives The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular disorder-induced neuronopathy. More specifically, the present inventio... | 08/16/2005 |
| 6844345 | Piperazine derivatives The present invention provides piperazine derivatives in accordance with formula (I) as well as salts, hydrates and esters thereof. The substituent designations are as provided in the specification. The compounds of th... | 01/18/2005 |
| 6800627 | Pirazino indole derivatives Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous system; damag... | 10/05/2004 |
| 6780862 | Aryl and aminoaryl substituted serotonin receptor agonist and antagonist ligands The present invention is directed to certain novel compounds represented by structural Formula (I): Sag-Tag (I) or a pharmaceutically acceptable salt thereof, wherein Sag and Tag are de... | 08/24/2004 |
| 6756376 | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein E is N or C—R4; G is N or C—R25; R1 ... | 06/29/2004 |
| 6703385 | Tricyclic compounds having sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): ##STR1## wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocycl... | 03/09/2004 |
| 6703401 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/09/2004 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6608199 | Synthesis of chlorinated pyrimidines The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl2). The imidoyl chloride compounds can be supplied as starting materials or can be produced b... | 08/19/2003 |
| 6552018 | Pyrazole derivatives The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): ##STR1## wherein G represents a nitrogen containing saturated heterocyclic structure ... | 04/22/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6524347 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treatin... | 02/25/2003 |
| 6482949 | Colormetric sensor compositions and methods The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as w... | 11/19/2002 |
| 6458792 | Compounds The present invention provides inhibitors of protein kinase C, of formula (I) ##STR1## wherein: one of: R1 and R2, R2 and R3 or R3 and R4, together form a 5 or 6 membered ring and the two groups of R1, R2, R3 and R4 not forming a ring, are H; and salts th... | 10/01/2002 |
| 6423716 | Nitrogenous heterocyclic compounds The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): ##STR1## wherein W represents 1,4-piperazinediyl, etc.; U represents NR1 R2 (wherein R1 represents a hydrogen atom, a ... | 07/23/2002 |
| 6413956 | Substituted 4-oxo-quinoline-3-carboxamides Disclosed are compounds of Formula I: ##STR1## or the pharmaceutically acceptable salts thereof where, R1, R2, and W are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain r... | 07/02/2002 |
