Did You Know...
...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8183372 | Substituted 9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydor-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazines The present invention is directed to a process for the preparation of a compound of formula 1b which compound is useful as a prodrug of HIV integrase inhibitors and therefore is useful in the inhibition of HIV replication, ... | 05/22/2012 |
| 8063214 | Polymorphic forms of tadalafil A process for preparing crystalline Form A of tadalafil (I), comprising crystallization from a solution of tadalafil in a solvent comprising a C3-C7 ester, a ketone, dimethylformamide, dimethylsulfoxide, ethanol, acetonitrile, a chlorinated hyd... | 11/22/2011 |
| 8058436 | Method for the preparation of enantiomerically pure mirtazapine The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with ... | 11/15/2011 |
| 7888506 | Composition, synthesis, and use of a new class of fluorophores A new class of fluorophores is presented. The fluorophores include a conjugated ring system, such as a dithiolone, a pyran, and a pyrazine containing ring system. The structure is designed with the flexibility to have multiple substitution patterns. The fluorophores... | 02/15/2011 |
| 7569689 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure ... | 08/04/2009 |
| 7419981 | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. A par... | 09/02/2008 |
| 7417044 | Tadalafil having a large particle size and a process for preparation thereof The present invention provides particulate tadalafil having a particle size of about 200 to about 600 microns and a process for controlling the particle size of tadalafil. ... | 08/26/2008 |
| 7417145 | Process for total synthesis of ecteinascidins and intermediates therefor An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2 of N12 site is trichloroethoxicarbonyl (Troc) to which various subs... | 08/26/2008 |
| 7355340 | Quinoxaline derivatives, organic semiconductor device and electroluminescent device The present invention is to provide quinoxaline derivatives, which have excellent electron transportation and hole blocking properties, and which can be formed into a film without being crystallized. According to the invention, quinoxaline derivatives represented by... | 04/08/2008 |
| 7345172 | Methods and compositions for detecting polynucleotide duplex damage and errors In accordance with the present invention there is provided a new class of sterically demanding metallo-intercalators. These compounds intercalate between bases in a duplex polynucleotide, but only where the bases are not fully complementary, for example, where there... | 03/18/2008 |
| 7312000 | Electrolytic solution for secondary battery and secondary battery containing the same A battery, which has excellent safety in an overcharged state and is excellent in low-temperature characteristics and cycle characteristics, is provided. The electrolytic solution of the secondary battery contains a compound which has a diazine N,N′-dioxide... | 12/25/2007 |
| 7285686 | Process for the preparation of 1,3-substituted indenes An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders. ... | 10/23/2007 |
| 7282586 | Dipyridine-based compound and the use thereof The present invention discloses a dipyridine-based compound which can be used as electron-transporting and/or hole blocking material or phosphorous host in organic electroluminescence devices is disclosed. The mentioned dipyridine-based compound is represented by th... | 10/16/2007 |
| 7265119 | Tartrate salts of 5,8,14-triazatetracyclo[10.3.1.0.0]-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene: and pharmaceutical compositions thereof. The present in... | 09/04/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7235662 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 06/26/2007 |
| RE39680 | Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7 | 06/05/2007 |
| 7223863 | Process for preparing Tadalafil and its intermediate The present invention relates an improved process for the preparation of tetrahydro-β-carboline derivative of formula (V) which is useful as an intermediate for the preparation of Tadalafil of formula (I). Moreover, the present invention relates to the process for ... | 05/29/2007 |
| 7205300 | Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthe... | 04/17/2007 |
| 7189724 | Quinoxaline derivatives having antiviral activity The invention provides substituted quinoxalines having the general formulas where R1, R2, R3, and R4 are, inter alia, alkyl, aryl, or heteroaryl groups; Z is NH or O; a... | 03/13/2007 |
| 7183282 | Substituted heterocycle fused γ-carbolines The present invention is directed to compounds useful for treating addictive behavior and sleep disorders represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1 | 02/27/2007 |
| 7144882 | Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthe... | 12/05/2006 |
| 7132419 | Pharmaceutical compounds A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I) wherein each of R1 to R4, which are the same or different, is selected from hydrogen, halogen, hydroxyl, C | 11/07/2006 |
| 7098209 | Pyrazino [1'2':1,6 ] pyrido [3, 4-b] indole-1,4-dione derivatives Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3′, 5′-monophosphate ... | 08/29/2006 |
| 7034027 | Fused heterocyclic derivatives as phosphodiesterase inhibitors Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 04/25/2006 |
| 7018738 | Electrode and battery using same An electrode including a compound acting as an electrode active material and represented by a general formula (1) having a diazine N,N′-dioxide structure. A novel battery with the higher specific density and the excellent charge and discharge stability can be prov... | 03/28/2006 |
| 6984641 | Carboline derivatives as PDE5 inhibitors Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed. ... | 01/10/2006 |
| 6962936 | Triazole-derived kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formula: where Ht, R2, T, and m are as described in the specification. The compounds are useful... | 11/08/2005 |
| 6962918 | Hexahydropyrazino[1'2';1,6]pyrido[3,4-b]indole-1,4-diones for the treatment of cardiovascular disorders and erectile dysfunction Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 11/08/2005 |
| 6960585 | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R | 11/01/2005 |
| 6951938 | Aryl fused azapolycyclic compounds Pharmaceutical compositions comprising compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, in combination w... | 10/04/2005 |
| 6933387 | Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles The present invention is directed to 1,2,3,4,10,10a-hexahydropyrazino [1,2-a]indole derivatives of formula (I): as well as pharmaceutically acceptable salts, hydrates and esters thereof, wherein the substituents have t... | 08/23/2005 |
| 6911542 | Pyrazino[1′,2′:1,6]pyrido[3,4b]indole derivatives Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 06/28/2005 |
| 6903099 | Condensed pyrazindione derivatives Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 06/07/2005 |
| 6897311 | Process for the preparation of decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]acenaphthylene and functionalized derivatives A process for the preparation of compound of formula (I A), decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]accnaphthylene and the corresponding functionalized compounds of general formula (I), intermediates for the preparation of 1,4,7,10-tetraazacyclododecane (II A) an... | 05/24/2005 |
| 6897310 | Aryl fused azapolycyclic compounds Pharmaceutical compositions comprising compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, in combination w... | 05/24/2005 |
| 6890927 | Tartrate salts of 5,8, 14-triazateracyclo[10.3.1.02,11 04.9]-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene: and pharmaceutical compositions thereof. The present inventio... | 05/10/2005 |
| 6878711 | Indole derivatives as PDE5-inhibitors Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 04/12/2005 |
| 6872721 | Derivatives of 2,3,6,7,12,12a-hexahydropyrazino-[1′,2′:1,6]pyrido[3,4b]-indole-1,4-dione Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 03/29/2005 |
| 6844345 | Piperazine derivatives The present invention provides piperazine derivatives in accordance with formula (I) as well as salts, hydrates and esters thereof. The substituent designations are as provided in the specification. The compounds of th... | 01/18/2005 |
