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| Number | Title | Issue Date |
| 7245073 | Quinoxaline derivatives, and light emitting element using thereof It is an object to provide an organic compound that has a bipolar property and also a light emitting property, and further has heat resistance. A quinoxaline derivative represented by a general formula (1) is provided. In the formula, A represents any one of ... | 07/17/2007 |
| 7189724 | Quinoxaline derivatives having antiviral activity The invention provides substituted quinoxalines having the general formulas where R1, R2, R3, and R4 are, inter alia, alkyl, aryl, or heteroaryl groups; Z is NH or O; a... | 03/13/2007 |
| 7135468 | Antibacterial compounds Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, composit... | 11/14/2006 |
| 6974872 | Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; | 12/13/2005 |
| 6967079 | Pyrimidine derivatives for labeled binding partners Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R1 is a binding partner, a linker or H; | 11/22/2005 |
| 6919458 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ... | 07/19/2005 |
| 6916925 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules. ... | 07/12/2005 |
| 6706707 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles This invention relates to a compound and the use of the compound of the formula wherein R1, R2, R3, R4 and R5 are as defined in the description, A signifies —CH═... | 03/16/2004 |
| 6703371 | Preparations for reducing oxygen consumption during physical efforts The invention relates to pharmaceutically active substances from the group comprising midazolam and compounds with a methyl-substituted nitrogen atom that is the ring atom of a nitrogenous heterocycle. These substances are used to reduce the oxygen consum... | 03/09/2004 |
| 6642222 | Pyrano, piperidino, and thiopyrano compounds and methods of use ##STR1## The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.... | 11/04/2003 |
| 6608048 | Tricyclic protein kinase inhibitors This invention provides compounds of Formula (I), ##STR1## where A", Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.... | 08/19/2003 |
| 6608194 | Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them A compound of Formula (Ih) ##STR1## The compounds may be used, inter alia, for preparing beta aryl-alpha-oxy substituted alkylcarboxylic acids.... | 08/19/2003 |
| 6583138 | Heterocyclic-ring condensed benzothiazine compound The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of t... | 06/24/2003 |
| 6548666 | Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them A compound of Formula (Ig) ##STR1## The compounds may be used, inter alia, for preparing beta aryl-alpha-oxy substituted alkylcarboxylic acids.... | 04/15/2003 |
| 6518423 | Benzopiperidine derivatives Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: ##STR1## wherein the variables are as described in the specification. These compounds are useful as ... | 02/11/2003 |
| 6468996 | Substituted hetero-polycyclic compounds as PPAR and PPARγ activators The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 10/22/2002 |
| 6462038 | Androgen receptor modulator compounds and methods Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for ... | 10/08/2002 |
| 6455534 | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: ##STR1## where: one of A or E is nitrogen, with rema... | 09/24/2002 |
| 6452011 | Process for production of piperidine derivatives The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: ##STR1## where Z is ##STR2## or ##STR3## and where m is 1 or 4-6; Q and Y are the... | 09/17/2002 |
| 6444824 | Process for production of piperidine derivatives The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: ##STR1## where Z is ##STR2## and where m is 1 or 3-6; Q and Y are the same or differen... | 09/03/2002 |
| 6440960 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this in... | 08/27/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6372904 | Process for manufacture of in vivo stain composition A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N'-dimethyl-.rho.-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not... | 04/16/2002 |
| 6235731 | Fused imidazopyridine derivatives as antihyperlipidemic agents A novel compound of the formula: ##STR1## wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is --Y0 --Z0, and the other tow groups are a hydrogen, a halogen, an optionally sub... | 05/22/2001 |
| 6191140 | Pyrano, piperidino, and thiopyrano compounds and methods of use The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.... | 02/20/2001 |
| 6071947 | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation The present invention relates to substituted (1H-indol-2-yl)-5[(2H-pyrrol-2-ylidene) methyl]-1H-pyrrole compounds and their use as immunomodulating agents, to the preparation of the compounds and to pharmaceutical compositions comprising them.... | 06/06/2000 |
| 6054453 | Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them Novel ଲ-aryl--oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. ##STR1## The compounds have hypolipidemic, antihyperglycemic uses.... | 04/25/2000 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5955460 | Oxazolidinone antibacterial agent with tricyclic substituents This invention provides novel oxazolidinone derivatives represented by chemical Formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein X is NR1, CR2 R3, O, S, SO, or SO2 ; and Z is NR | 09/21/1999 |
| 5910586 | Tricyclic aminoalkylcarboxamides; dopamine D3 receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: R1 -R4 represent organic or inorganic groups; A represents an alkylene group of 2 to 6 carbon atoms optionally ... | 06/08/1999 |
| 5728693 | Arthropodicidal oxadiazine-thiadiazine-or triazine-carboxanilides Arthropodicidal compounds, compositions and use of compounds having the formula ##STR1##... | 03/17/1998 |
| 5690906 | Dopamine D-3 and serotonin (5-HT1A) receptor ligands and imaging agents Tetralin derivatives, such as 7-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)-amino!tetralin and 8-hydroxy-2-(N-n-propyl-N-3 '-iodo-2'-propenyl)amino-tetralin, are disclosed which have affinity and specificity for dopamine D-3 and/or serotonin 5-HT1A... | 11/25/1997 |
| 5539107 | Method for the production of azaphenothiazines A process for the production of azophenothiazine derivatives having either of the following structures: ##STR1## where X and Y include alkyl, alkoxy, halogen, hydrogen, carboxy, or carboxy alkyl substituents. These compounds are precursors to ph... | 07/23/1996 |
| 5527908 | Pyrazolothiazolopyrimidine derivatives Pyrazolothiazolopyrimidine derivatives represented by the Formula ##STR1## and pharmaceutically acceptable salts thereof are useful as anti-inflammatory, analgesic, immunomodulatory and anti-ulcer agents.... | 06/18/1996 |
| 5512564 | Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them The present invention concerns thiazolo- 2,3-a!pyrrole and oxazolo- 1,2-a!pyrrole derivatives of formula I ##STR1## in which HET represents a heterocyclic ring with 3-7 ring atoms which can be substituted by one, two or three residues R1 w... | 04/30/1996 |
| 5446148 | Method for the production of azaphenothiazines 6-aza-benzo[b]-phenothiazine derivatives having the formula, ##STR1## wherein X and Y can be any of hydrogen, lower alkyl, lower haloalkyl, carboxyl or carboxy alkyl are obtained through a reaction of 2-quinioline derivatives having the formula ... | 08/29/1995 |
| 5418231 | Pyrimido-benzothiazines This invention relates to novel pyrimido-benzothiazine derivative compounds. ##STR1## The compounds of the present invention inhibit the action of the lipoxygenase enzyme and are useful in the treatment or alleviation of inflammatory diseases, a... | 05/23/1995 |
| 5380718 | Arthropodicidal fused tetrahydropyridazines Arthropodicidal tetrahydropyridazines of Formulae I and II, ##STR1## wherein Q,X,X1 Y, and G are as defined in the text, compositions containing them and their use in the control of arthropods.... | 01/10/1995 |
| 5308840 | Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A i... | 05/03/1994 |
| 5276039 | Substituted indazole arthropodicides Indazole arthropodicides, compositions containing them and a method for controlling arthropods employing these indazoles as the active ingredient. The indazoles have the following general formula wherein Q, X, Y, R1 and m are as defined in the ... | 01/04/1994 |
