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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8178673 | Phosphonic acid compounds as inhibitors of serine proteases The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders. ... | 05/15/2012 |
| 8129527 | Analogs of dehydrophenylahistins and their therapeutic use Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associ... | 03/06/2012 |
| 7858787 | Process for producing olefins A process for converting an olefin having x carbon atoms into an olefin having x+1 carbon atoms wherein the process comprises the steps of: (i) reacting an olefin having x carbon atoms with carbon monoxide and hydrogen in the prese... | 12/28/2010 |
| 7626020 | Protected forms of N-(3-methoxy-5-methylpiperazin-2-yl)-2-(4-[1,3,4,-oxadiazol-2-yl]phenyl)-pyridine-3-sulphonamide The invention relates to compounds such as where P is a nitrogen-protecting group, and to processes for preparing these compounds. ... | 12/01/2009 |
| 7608709 | 2, 3-bis(dialkylphosphino)pyrazine derivative, process of producing the same, and metal complex having the same as ligand An optically active 2,3-bis(dialkylphosphino)pyrazine derivative represented by formula (1) is disclosed. The pyrazine derivative is preferably a quinoxaline derivative represented by formula (2). In formula (1) and (2), R1 is preferably a t-butyl or adam... | 10/27/2009 |
| 7449577 | High purity piperazine pyrophosphate and process of producing same The present invention provides piperazine pyrophosphate represented by chemical formula (I) which has a sodium content of 10 ppm or lower and a process of producing the same. The piperazine pyrophosphate has high purity and provides a flame retardant composition exh... | 11/11/2008 |
| 7361786 | Bisphosphines as bidentate ligands The present invention relates to ligands of the general formula (I). In addition, a process for the production thereof and the use thereof are demonstrated. ... | 04/22/2008 |
| 7067501 | Aryloxyphenyl and arylsulfanylphenyl derivatives The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors. ... | 06/27/2006 |
| 7060290 | Phosphocholine linked prodrug derivatives Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substitute... | 06/13/2006 |
| 7001911 | Fused cyclic modulators of nuclear hormone receptor function The invention pertains to fused cyclic compounds having the formula, wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′ or NR10 | 02/21/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6916797 | α-arylethylpiperazine derivatives as neurokinin antagonists The invention relates to new α-arylethylpiperazine of the formula wherein Z represents 0 or S; n′ represents 1 or 2; R2 represents a hy... | 07/12/2005 |
| 6906074 | 2-phenylpiperazine derivatives A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof: wherein each of X1 and X3 is oxygen or two hydrogen atoms, X... | 06/14/2005 |
| 6800629 | Pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof Pyrazine derivatives represented by general formula [1]: wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating... | 10/05/2004 |
| 6706698 | α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and ver... | 03/16/2004 |
| 6699855 | Inhibitors of hepatitis C virus NS3 protease The present invention relates to compounds of Formula (I): ##STR1## wherein A1 is methylene, ethylene or propylene group and A2 is N or CR5, or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable ... | 03/02/2004 |
| 6645904 | Aminophosphonium compounds The present invention relates to compounds of the formula ##STR1## in which one, two or three of the radicals R1, R2, R3 and R4 are ##STR2## where m and n are an integer from 1 to 10, R5, R6 | 11/11/2003 |
| 6620934 | Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula ##STR1## wherein A is the no... | 09/16/2003 |
| 6608067 | Inhibitors of serine proteases, particularly HCV NS3 protease The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be... | 08/19/2003 |
| 6576760 | Processes for synthesis of cyclic and linear polyamine chelators containing N-monosubstituted coordinating arms Polyamines containing at least two nitrogen atoms monosubstituted with pendant arms capable of coordinating metal cations, or with precursors of such pendant arms, all nitrogen atoms of the polyamines except two being fully substituted and the remaining t... | 06/10/2003 |
| 6562783 | Phosphinylmethyl and phosphorylmethyl succinic and glutauric acid analogs as ଲ-secretase inhibitors The invention provides a compound of formula (I): ##STR1## or salts or hydrates thereof, useful as beta-secretase inhibitors. The invention further relates to a method of reducing plaque formation, particularly useful in the treatment of Alzheimer's disea... | 05/13/2003 |
| 6498161 | Pyrrolidine modulators of chemokine receptor activity The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4, R5, R6 and n are defined herein) which are useful as modulators of chemokine r... | 12/24/2002 |
| 6486165 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formula I ##STR1##... | 11/26/2002 |
| 6465643 | Aminophosphonium compounds The present invention relates to compounds of the formula ##STR1## in which one, two or three of the radicals R1, R2, R3 and R4 are ##STR2## where m and n are an integer from 1 to 10, R5, R6 | 10/15/2002 |
| 6455530 | 2R,4S,S,S- and 2S,4R,S,S-hydroxyitraconazole A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containin... | 09/24/2002 |
| 6451824 | Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 09/17/2002 |
| 6448401 | Process for water soluble azole compounds An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antif... | 09/10/2002 |
| 6399782 | Benzimidazole inhibitors of fructose 1,6-bisphosphatase Novel benzimidazole compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described ##STR1##... | 06/04/2002 |
| 6395749 | Carboxamide compounds, methods, and compositions for inhibiting PARP activity The present invention provides carboxamine compounds, methods and compositions for inhibiting PARP activity.... | 05/28/2002 |
| 6365592 | Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1B (PTP-1B) The invention encompasses compounds represented by formula I: ##STR1## as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.... | 04/02/2002 |
| 6362172 | Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula ##STR1## wherein A is the no... | 03/26/2002 |
| 6340758 | Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents Described are neuroprotective agents of Formula I ##STR1## wherein R is an amino acid or nitrogen heterocyclic ring which is saturated or unsaturated of from 5 to 8 members which may have additional oxygen or sulfur atoms therein. The other provisions or ... | 01/22/2002 |
| 6333424 | Therapeutic derivatives of diphosphonates Compounds having utility in achieving the foregoing objects of the invention are prepared by reacting a 2,2-bis-(disubstituted-phosphoryl)-ethylsulfanyl-acetic acid compound with a pharmaceutically active chemical entity effective to treat the underl... | 12/25/2001 |
| 6313294 | Process for preparing amides The present invention provides a process for preparing an amide, which comprises reacting an amine with an ester in a molten form in the absence of a solvent.... | 11/06/2001 |
| 6291700 | Method for preparing sterically hindered phosphoramidates Sterically hindered phosphoramidates such as N,N'-bis[di-(2,6-xylyl)phosphoryl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing at le... | 09/18/2001 |
| 6277988 | Solvent-free method for preparing sterically hindered phosphoramidates Sterically hindered phosphoramidates such as N,N'-bis[di-(2,6-xylenoxy)phosphinyl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing ... | 08/21/2001 |
| 6248816 | Thermoplastic polymer composition containing dye compositions The present invention relates to a polymeric composition suitable for use in films, molded articles and fibers, including microdenier fibers. The polymeric composition comprises a thermoplastic resin in an amount from about 50 weight percent to about 99.9... | 06/19/2001 |
| 6211182 | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms This invention discloses novel imidazoles substituted with a six or seven membered heterocyclic ring which contains two nitrogen atoms as part of the heterocyclic ring structure. These compounds have excellent histamine-H3 receptor antagonist a... | 04/03/2001 |
| 6191276 | Method for preparing sterically hindered phosphoramidates Sterically hindered phosphoramidates such as N,N'-bis[di-(2,6-xylenoxy)phosphoryl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing ... | 02/20/2001 |
| 6177528 | Substituted aminomethylphosphines, compositions and coordination complexes of same, their synthesis and processes using same Novel aminomethylphosphine ligands have particular substituents on the central carbon atom. Such ligands form coordination complexes that may be catalysts for the polymerization of monomers or other catalytic induced reactions.... | 01/23/2001 |
