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| Number | Title | Issue Date |
| 5817836 | 2,4-pentadienoic acid derivatives having retinoid-like biological activity Compounds of Formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 | 10/06/1998 |
| 5817879 | Alicyclic peptidomimetics Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R | 10/06/1998 |
| 5808124 | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 09/15/1998 |
| 5795890 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 08/18/1998 |
| 5789422 | Substituted arylalkylamines as neurokinin antagonists Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof are disclosed, wherein: A1 is --CH2 R6, --OR6, --N(R6)(R7), --S(O)e R | 08/04/1998 |
| 5786478 | Process for preparing cyanopyrazine This invention relates to a vapor phase process for preparing cyanopyrazine, in particular which is reacting 2-methylpyrazine with ammonia and oxygen over molybdenum-phosphorus oxide-based catalyst of the following formula having the high selectivity and ... | 07/28/1998 |
| 5783576 | Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.... | 07/21/1998 |
| 5780647 | 2,4-Pentadienoic acid derivatives having retinoid-like biological activity Compounds of Formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 | 07/14/1998 |
| 5780470 | Melatonergic indanyl piperazines Certain indanyl piperazines are useful as melatonergic agents and can treat various CNS disorders. They are use useful in treating sleep disorders and other conditions related to circadian rhythms.... | 07/14/1998 |
| 5780437 | Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m... | 07/14/1998 |
| 5776363 | Compounds having side chains with multiple methyl branches and their use in liquid-crystal mixtures Compounds of the formula (I) having side chains with multiple methyl branches R1 (-A1 -M1)a (-A2 -M2)b (-A3 -M3)c (-A4)-G(--C.sub.* H(CH | 07/07/1998 |
| 5777162 | Intermediates for the preparation of fungicides Described herein are compounds of Formula (XX) and Formula (XXIV), shown below, and processes of making same. ##STR1## wherein p is 0 ##STR2## wherein p is 1, and Y is chlorine or bromine.... | 07/07/1998 |
| 5763144 | Color-photographic recording material The invention relates to a color-photographic recording material which comprises a magenta coupler and, as stabilizer, at least one compound of formula (Ia), (Ib) or (II), where the radicals are as defined in claim 1, and to the novel stabilizers.... | 06/09/1998 |
| 5756769 | Method for producing propargylamine compounds A method for producing a propargylamine compound represented by the general formula (I): ##STR1## which comprises reacting a propargyl compound represented by the general formula (II): ##STR2## with an aromatic aldehyde represented by the g... | 05/26/1998 |
| 5756532 | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino2 3-E!-indol-8-ones and derivatives The compounds of formula I: ##STR1## wherein R1 and R2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R1 and R2, taken together, are benzylidene optionally substituted with R3 as defin... | 05/26/1998 |
| 5741912 | Methods for preparing heteroatom-bearing ligands and metal complexes thereof Novel compounds containing a heteroatom-bearing bridge and novel complexes of these compounds with metals. The novel compounds and complexes are useful in diagnostic and therapeutic methods.... | 04/21/1998 |
| 5733912 | 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula ##STR1## wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mamm... | 03/31/1998 |
| 5723621 | Process for processing biaryl compound A novel process for producing a biaryl compound represented by formula (III), which is useful as a medicine, an agricultural chemical and an electrooptical liquid-crystal display material: Ar--Ar' (III) (where... | 03/03/1998 |
| 5723611 | Heteroarylpiperidines A compound of formula (VIII): ##STR1## in which Alk is a (C1 -C4)alkyl group, R.cndot. is hydrogen or a protecting group cleavable by hydrolysis and R is hydrogen, a protecting group cleavable by reduction or a heterocycle of st... | 03/03/1998 |
| 5723460 | Cyclo (alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR1, wherein R1 is an optionally substituted alkyl group; X is --O--, --S--, or --N(R6), wherein R6 is a hydr... | 03/03/1998 |
| 5716542 | Liquid crystal compound and liquid crystal composition containing the same A liquid crystal compound represented by formula (I) and a liquid crystal composition containing the same. The compound exhibits an antiferroelectric liquid crystal phase and has good compatibility with known liquid crystal compounds. ##STR1## w... | 02/10/1998 |
| 5710242 | High temperature epoxy resins from hydrogenated quinoxalines A multi-functional epoxy resin with good high temperature properties allowing prolonged service at temperatures above 120° C. is derived from a precursor of formula (I): ##STR1## in which R3 to R8 inclusive are independently se... | 01/20/1998 |
| 5708123 | Electroactive materials, a process for their preparation as well as the use thereof Stable, electroactive material which when a potential is applied from the outside is subjected to one or more reversible redox reactions, for use in devices with an electrochromic display or another electrochromic color change or in batteries. The materia... | 01/13/1998 |
| 5693809 | Substituted 4-aza-5-androstan-ones as 5-reductase inhibitors Described are new 16-substituted and 7,16-disubstituted 4-aza-5-androstan-3-ones and related compounds as 5-reductase inhibitors.... | 12/02/1997 |
| 5691356 | Disubstituted heterocyclic thrombin inhibitors Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q is a single bond or ##STR3## and Z... | 11/25/1997 |
| 5686484 | Milbemycin derivatives, their preparation and their use Compounds of formula (I): ##STR1## and of formula (I)w : ##STR2## in which: A represents group having one of the following formulae: ##STR3## wherein R2, R3 and R4 are independently selected from ... | 11/11/1997 |
| 5684152 | Preparation of carboxyalkyl derivatives as inhibitors of matrix metalloproteinases Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal u... | 11/04/1997 |
| 5679793 | Process for the preparation of substituted pyrazines Process for the preparation of substituted pyrazines comprising the reaction of a dihydroxyketone of formula ##STR1## wherein R1 et R2 each represent a hydrogen atom, a saturated or unsaturated, linear or branched, hydrocarbon r... | 10/21/1997 |
| 5670453 | Herbicidal hydroxybenzyl-substituted heteroaryl compounds and derivatives thereof Herbicidal substituted hydroxybenzyl-heteroaryl compounds and derivatives thereof of the formula ##STR1## wherein Ar is a substituted or unsubstituted 5- or 6-membered heteroaryl group having 2 or 3 ring nitrogen atoms or a substituted or unsubstitut... | 09/23/1997 |
| 5668137 | N-heterocyclic sulfonamides having endothelin receptor activity The invention concerns pharmaceutically useful compounds of the formula I, in which R1, R2, R3, n, m and Het have any of the meanings defined herein, and their pharmaceutically-acceptable salts, and pharmaceutical composit... | 09/16/1997 |
| 5668176 | Phenoxyphenylacetic acid derivatives Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral... | 09/16/1997 |
| 5668281 | Process for preparing tertiary amine-N-oxide A process for preparing a tertiary amine-N-oxide which comprises reacting a tertiary amine with a peroxide in the presence of a catalyst comprising an oxide containing silicon and titanium atoms. According to the process of the present invention, a tertia... | 09/16/1997 |
| 5665270 | Optically active trifluorolactic acid derivative and liquid crystal composition An optically active compound derived from a novel trifluorolactic acid, useful as a component of a ferroelectric liquid crystal composition, and a liquid crystal composition. A compound represented by general formula (I), wherein R1 represents ... | 09/09/1997 |
| 5662828 | Compound having unsaturated side chain, process for preparing the same, liquid crystalline polymer prepared from the same, liquid crystal mixture and display element A compound having an unsaturated side chain represented by the formula: ##STR1## in which A and B are the same and different and represent an aromatic or heterocyclic group or either one of A and B represents a single bond; X1, X2 | 09/02/1997 |
| 5659039 | Quinophthalone compounds Novel quinophthalone compounds, which are represented by the following formula (1): ##STR1## R1 -R5 each independently represents a hydrogen or halogen atom or a hydroxy, linear or branched alkyl, substituted or unsubstituted ... | 08/19/1997 |
| 5658489 | Diphenylacetylene compound, process for preparing the same and liquid crystal composition and element comprising the same A diphenylacetylene compound of the formula [1]: ##STR1## wherein R is a C1 -C12 alkyl group, a C2 -C12 alkenyl group or a C2 -C16 alkoxyalkyl group; X1, X2, X3 | 08/19/1997 |
| 5658907 | Compounds and methods for inhibition of HIV and related viruses Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.... | 08/19/1997 |
| 5658924 | 1,8-naphthyridin-2-one derivative and use thereof The present invention relates to 1,8-naphthyridin-2-one derivatives, pharmaceutically acceptable acid addition salts and therapeutic agents comprising said compound as an active ingredient, which are used for the diseases such as circulatory diseases and ... | 08/19/1997 |
| 5654428 | Substituted heteroarylphenyloxazolidinones The present invention discloses novel substituted aryl- and heteroarylphenyloxazolidinones which are useful as anti-bacterial agents. More specifically, the substituted aryl- and heteroarylphenyloxazolidinones of the invention are characterized by ox... | 08/05/1997 |
| 5654306 | Piperidine derivative and pharmaceutical composition A piperdine derivative having the formula (I) or a pharmacologically acceptable salt thereof: R1 --X--A--R2 (I) wherein R1 is selected from the group consisting of substituted or unsubstituted... | 08/05/1997 |
