Class 544/336 - 1,4-diazines

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the six-membered hetero ring has nitrogens
No. of patents: 810
Last issue date: 05/22/2012

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Number	Title	Issue Date
7259163	4-(6-membered)-heteroaryl acyl pyrrolidine derivatives as HCV inhibitors Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl...	08/21/2007
7259179	Kinase inhibitors A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states usin...	08/21/2007
7256188	3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam...	08/14/2007
7250414	Diphenylmethyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, e, m, n, Ar1, R1, R2, R3, R4a, R4b, R5 and R6 are as defined ...	07/31/2007
RE39754	Benzamide derivatives and pharmaceutical compositions containing same The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune...	07/31/2007
7229988	Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen spe...	06/12/2007
7223762	Beta-amino acid derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su...	05/29/2007
7220753	2,7-substituted octahydro-1H-pyrido[1,2-a]pyrazine derivatives as ligands for serotonin receptors Substituted pyrido[1,2-a]pyrazines of general formula I; wherein Ar and Ar1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO2, CHOH, C═O, or —(CR3R4); and n is 0–2, as well as ...	05/22/2007
7220741	1,4-diazabicycloalkane derivatives, their preparation and use This invention relates to novel 1,4-diazabicycloalkane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the mono...	05/22/2007
7220783	Para-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do...	05/22/2007
7220740	1,4-diazabicyclo[3.2.2]nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof Compound corresponding to the general formula (I) in which X represents an oxygen or sulphur atom or an NH group and R1, R2, R3 and R4 each represent a hydrogen or halo...	05/22/2007
7220735	Benzimidazolone histamine Hantagonists Disclosed are novel compounds of the formula wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally s...	05/22/2007
7217714	CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m...	05/15/2007
7214701	Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ...	05/08/2007
7208169	Biphenyl carboxamides The invention relates to novel biphenylcarboxamides of the formula (I) in which R1, R2, m, n, R3, Y and A are as defined in the disclosure, to a plurality...	04/24/2007
7205302	Heterocyclic compound derivatives and medicines The present invention provides a compound which is useful as a PGI2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]...	04/17/2007
7202244	Chk-1 inhibitors Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy. ...	04/10/2007
7202368	Process for the preparation of 4-(benzimidazolymethylamino) benzamidines A process for preparing an optionally substituted 4-benzimidazol-2-ylmethylamino)benzamidine, the process comprising: (a) condensing an optionally suitably substituted diaminobenzene with 2-[4-(1,2,4-oxadiazol-5-on-3-yl)phenylamino...	04/10/2007
7196084	Cdc25 phosphatase inhibitors The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected amon...	03/27/2007
7186847	Process for the direct preparation of pyrrolo[3,4-c]pyrroles The present invention relates to a process for the direct preparation of pyrrolo[3,4-c]pyrroles (DPPs) of the formula (1), pigment compositions containing them and their use for coloring high molecluar weight organic materials, such as plastics and paints. The obtai...	03/06/2007
7186843	Aminomethylpyrrolidine derivatives having aromatic substituents This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of th...	03/06/2007
7179807	5-substituted-2-arylpyrazines Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators or CRF receptors. Compounds of the invention are provided by the following formula: The 5-substituted-2-aryl...	02/20/2007
7176200	Derivatives of sulphonamides, their preparation and use as medicaments The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the ph...	02/13/2007
7176312	Kinase inhibitor scaffolds and methods for their preparation General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, bor...	02/13/2007
7173131	Anthryl derivative group substituted compound, and organic luminescent device making use of same An anthryl derivative group substituted compound having a specific chemical structure is provided. This compound is used for producing an organic luminescent device which can emit luminescent hues with a very high purity and effect light emission with a high lumines...	02/06/2007
7160872	Methods to treat conditions mediated by chemokine receptors The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as othe...	01/09/2007
7160896	Therapeutic acridone and acridine compounds The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is a double bon...	01/09/2007
7153868	N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a c...	12/26/2006
7153815	Insecticide containing hydrazone derivative as the active ingredient and novel hydrazone derivative A insecticide characterized by containing as active ingredient a hydrazone derivative of formula (I) wherein A and Q are an aryl or a heterocyclic group, W is oxygen atom, an aminylene, an alkylene group, an oxya...	12/26/2006
7153857	Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13. ...	12/26/2006
7148311	Liquid crystal polymers Liquid crystal polyester derived from phenylene-naphthalene monomers and one or more comonomers display an improved balance of properties, including low melt viscosity, fast cycle time in molding, very low mold shrinkage, high tensile and/or flexural strength, solve...	12/12/2006
7145004	Method for the production of monohydro-perfluoroalkanes, bis(perfluoroalkyl)phosphinates and perfluoroalkylphosphonates The present invention relates to a process for the preparation of monohydroperfluoroalkanes, bis(perfluoroalkyl)phosphinates and perfluoroalkylphosphonates which comprises at least the treatment of at least one perfluoroalkylphosphorane with at least one base in a s...	12/05/2006
7135499	Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form...	11/14/2006
7125878	Substituted pyrroline kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. ...	10/24/2006
7122550	Protein kinase inhibitors A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms of diastereomers thereof is described. A method of treating protein kinase-associated disease states usin...	10/17/2006
7119203	Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop...	10/10/2006
7105505	Benzimidazole derivatives useful as histamine H3 antagonists Disclosed are novel compounds of the formula wherein R1 is optionally substituted benzimidazolyl or a derivative thereof; R2 is optionally substituted aryl or heteroaryl; M1 and M...	09/12/2006
7105671	Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of...	09/12/2006
7102014	Pigment dispersants based on diketopyrrolopyrrole compounds and pigment preparations The invention provides novel pigment dispersants of the formula (I): in which Q is a radical of the formula (Ia): s is a number from 0.1 to 4.0 and n is a...	09/05/2006
7101915	P-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do...	09/05/2006

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Class 544/336 - 1,4-diazines