Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 8119801 | HIV inhibiting 2-(4-cyanophenyl)-6-hydroxylaminopyrimidines HIV replication inhibitors of formula pharmaceutically acceptable addition salts; or stereochemically isomeric forms thereof, wherein R1 is halo; R2 and R3 each independently are C1-6 | 02/21/2012 |
| 8101752 | Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile This invention relates to a process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)-amino]benzonitrile (I) starting from a 4-oxo-1,6-dihydro-pyrimidinylcarboxylic acid ester (II) or starting from a guanidine derivative which is reacted with an alkoxy-methylene ma... | 01/24/2012 |
| 8003789 | HIV replication inhibiting pyrimidines This invention concerns the use of compounds of formula the N-oxides, pharmaceutically acceptable addition salts, quaternary amines, stereochemically isomeric forms thereof, wherein -a1=a2-a3 | 08/23/2011 |
| 7897763 | Process for the preparation of substituted phenylalanines Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: ... | 03/01/2011 |
| 7442705 | HIV replication inhibiting pyrimidines and triazines This invention concerns HIV replication inhibitors of formula (I), The N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, their use as a medicine, their processes for preparation and pharm... | 10/28/2008 |
| 7429594 | Substituted heterocyclic compounds and methods of use The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 ato... | 09/30/2008 |
| 7427681 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula II: wherein Z1 is nitrogen or CR8; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, whe... | 09/23/2008 |
| 7423148 | Small molecule PI 3-kinase inhibitors and methods of their use Compounds having formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable ca... | 09/09/2008 |
| 7414011 | Phenylsulfonyl ureas, process for their preparation and their use as herbicides and plant growth regulators Disclosed are compounds of the formula (I) or salts thereof in which R1, R2, R3, R4, I, R5, Q, R4, W, X, Y, V and Z, are as defined in the specification, whi... | 08/19/2008 |
| 7378413 | 2-amino-3-(alkyl)-pyrimidone derivatives A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C1-6 alkyl group which may be substituted by a C6,10 aryl group; ... | 05/27/2008 |
| 7355044 | Self-assembling dyes A novel dye according to formula (I): capable of self-assembling thus forming supra-molecular structures. These self-assembling dyes may be advantageously used in an ink-jet ink for improving the stability of ink-jet ink im... | 04/08/2008 |
| 7345050 | Pyrimidine compounds The present invention relates to new compounds of the formula (I) a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, as well as intermediates used in the p... | 03/18/2008 |
| 7335672 | Vanilloid receptor ligands and their use in treatments Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inf... | 02/26/2008 |
| 7282469 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines A description is given of 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines of the formula (I) and of their use as herbicides. In this formula (I), R1, R2, R3 and R | 10/16/2007 |
| 7276510 | HIV replication inhibitors This invention concerns HIV replication inhibitors of formula the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, provided that whe... | 10/02/2007 |
| 7268141 | Xanthine phosphodiesterase V inhibitors A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: | 09/11/2007 |
| 7265222 | Process of making di-aryl urea compounds Disclosed is a process of making compounds of formula(I): wherein R1, R2, R3, R4 and Ra of formula(I) are defined herein. The product compounds inhibit production of cy... | 09/04/2007 |
| 7265221 | Pyrrolo[2,3-d]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as i... | 09/04/2007 |
| 7256199 | Pyrimidone derivatives A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein R1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; R | 08/14/2007 |
| 7250420 | Method of treatment of transplant rejection A method of treating or preventing chronic organ transplant rejection comprising administering a compound of the formula wherein R1, R2 and R3 are as defined above. ... | 07/31/2007 |
| 7247633 | Pyrimidine compounds and their use A compound of the general formula (I): wherein R1, R2, X, Y and Z are as described in the specification. ... | 07/24/2007 |
| 7241458 | Antiviral compositions The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture co... | 07/10/2007 |
| 7230104 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered h... | 06/12/2007 |
| 7208499 | Pyrimidine derivatives for the treatment of abnormal cell growth The present invention relates to a compound of the formula 1 wherein A and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals... | 04/24/2007 |
| 7183287 | Substituted pyrimidinones Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating ... | 02/27/2007 |
| 7153964 | Pyrimidine compounds Pyrimidine derivatives of formula (I) wherein: Qh1 and Q2 are independently selected from aryl or carbon linked heteroaryl optionally substituted as defined within; and one of Q1 and Q2 or both Q1 and Q2 | 12/26/2006 |
| 7141531 | Combinations of phenylsulfonylurea herbicides and safeners The invention relates to combinations of sulfonylurea herbicides (A) and their salts in which R2 is H, OH, aliphatic hydrocarbon radical or hydrocarbon-oxy radical, and R1 is an acyl radical... | 11/28/2006 |
| 7115601 | HIV integrase inhibitors Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating HIV infection and AIDS. ... | 10/03/2006 |
| 7109204 | Tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogen... | 09/19/2006 |
| 7091208 | Pyrrolo[2,3-D]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as i... | 08/15/2006 |
| 7087597 | Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof Compounds of the formula wherein R1, R2, R3, R4, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be use... | 08/08/2006 |
| 7078410 | 2-arylamino-pyrimidines for the treatment of GSK3-related disorders An aqueous solution for prophylactic treatment of teats of lactating mammals, comprising as a first component at least partially deacetylated chitosan, or an acid addition salt thereof, in a concentration of up to about 2% by weight of chitosan, the solution having ... | 07/18/2006 |
| 7067522 | 2,4,DI (hetero-) arylamino (-oxy)-5-substituted pyrimidines as antineoplastic agents Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compos... | 06/27/2006 |
| 7057043 | Processes for preparing aminophenylsulfonylureas, and intermediates therefor The invention relates to the preparation of compounds (I) in which A=H or acyl and R1, R2, R3, R, n, X, Y and Z are as defined in claim 1 by halogenation and rearrangement ... | 06/06/2006 |
| 7037917 | HIV replication inhibiting pyrimidines This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2 | 05/02/2006 |
| 7038060 | Synthesis of 2-butyl-3-(2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspiro[4.4]-non-ene-4-one Provided is a novel method of making 2-butyl-3-[[2′(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan. ... | 05/02/2006 |
| 7034019 | Prodrugs of HIV replication inhibiting pyrimidines The present invention concerns compounds of formula (A1)(A2)N—R1 (I),the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is sub... | 04/25/2006 |
| 7001910 | Thiazolidinedione derivatives as antidiabetic agents The present invention refers to compounds of the general formula (I), to their possible pharmaceutically acceptable salts and tautomeric forms. The present invention also refers to a process for their production and to their use as antidiabetic and *hypoglycemic age... | 02/21/2006 |
| 6960688 | Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ... | 11/01/2005 |
| 6943252 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5-... | 09/13/2005 |
