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| Number | Title | Issue Date |
| 8178671 | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases tha... | 05/15/2012 |
| 8030487 | 2-amino—5-substituted pyrimidine inhibitors Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases. ... | 10/04/2011 |
| 7880000 | Protein kinase modulators and method of use The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating vari... | 02/01/2011 |
| 7855291 | Process for the preparation of substituted phenylalanines Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: ... | 12/21/2010 |
| 7427681 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula II: wherein Z1 is nitrogen or CR8; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, whe... | 09/23/2008 |
| 7423148 | Small molecule PI 3-kinase inhibitors and methods of their use Compounds having formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable ca... | 09/09/2008 |
| 7414011 | Phenylsulfonyl ureas, process for their preparation and their use as herbicides and plant growth regulators Disclosed are compounds of the formula (I) or salts thereof in which R1, R2, R3, R4, I, R5, Q, R4, W, X, Y, V and Z, are as defined in the specification, whi... | 08/19/2008 |
| 7378413 | 2-amino-3-(alkyl)-pyrimidone derivatives A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C1-6 alkyl group which may be substituted by a C6,10 aryl group; ... | 05/27/2008 |
| 7371858 | Guanidinopyrimidinone compounds and phase change inks containing same Compounds of the formulae wherein, provided that at least one of R1, R2, and R3 is not a hydrogen atom, R1, R2, and R3 each, independently of the other, is h... | 05/13/2008 |
| 7365073 | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, a... | 04/29/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7355044 | Self-assembling dyes A novel dye according to formula (I): capable of self-assembling thus forming supra-molecular structures. These self-assembling dyes may be advantageously used in an ink-jet ink for improving the stability of ink-jet ink im... | 04/08/2008 |
| 7335672 | Vanilloid receptor ligands and their use in treatments Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inf... | 02/26/2008 |
| 7288547 | CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I or If as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases. ... | 10/30/2007 |
| 7282469 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines A description is given of 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines of the formula (I) and of their use as herbicides. In this formula (I), R1, R2, R3 and R | 10/16/2007 |
| 7281125 | Securing sensitive configuration data remotely A method, computer program product and computer system for securing alterable data. A computer that is remotely managed may be equipped with a protected storage that is accessible only by BIOS code. The protected storage may have the capacity to store a symmetrical ... | 10/09/2007 |
| 7279469 | Diaminotriazoles useful as inhibitors of protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... | 10/09/2007 |
| 7265222 | Process of making di-aryl urea compounds Disclosed is a process of making compounds of formula(I): wherein R1, R2, R3, R4 and Ra of formula(I) are defined herein. The product compounds inhibit production of cy... | 09/04/2007 |
| 7256199 | Pyrimidone derivatives A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein R1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; R | 08/14/2007 |
| 7247633 | Pyrimidine compounds and their use A compound of the general formula (I): wherein R1, R2, X, Y and Z are as described in the specification. ... | 07/24/2007 |
| 7241458 | Antiviral compositions The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture co... | 07/10/2007 |
| 7230104 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered h... | 06/12/2007 |
| 7211581 | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives The invention relates to a 2-(diaza-bicyclo-alkyl)-pyrimidone derivative represented by formula (I): wherein: R1 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R2 repres... | 05/01/2007 |
| 7208596 | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression | 04/24/2007 |
| 7208499 | Pyrimidine derivatives for the treatment of abnormal cell growth The present invention relates to a compound of the formula 1 wherein A and Ar are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals... | 04/24/2007 |
| 7205265 | Cleaning compositions and methods of use thereof A remover composition and method for removing resists from substrates containing nucleophilic amine and at least one solvent is described. Optionally, a chelating agent can also be included in the remover composition. The remover composition is especially suitable f... | 04/17/2007 |
| 7183287 | Substituted pyrimidinones Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating ... | 02/27/2007 |
| 7176312 | Kinase inhibitor scaffolds and methods for their preparation General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, bor... | 02/13/2007 |
| 7160892 | Pyrimidone compounds and pharmaceutical compositions containing the same The invention provides novel pyrimidone compounds exhibiting excellent antagonism against adenosine receptors (A1, A2A, and A2B receptors), particularly, compounds represented by the general formula (1), salts thereof, or solvates of... | 01/09/2007 |
| 7138404 | 4-aminopyrimidine derivatives This invention is 4-aminopyrimidine derivatives of the formula wherein R1, R2, R3 and R4 are as defined in the specification or a pharmaceutically acceptable salt there... | 11/21/2006 |
| 7135467 | HIV integrase inhibitors Compounds useful for treating HIV are disclosed having the general formula wherein R1, R2, and B are as defined in the specification. Compositions containing the compounds and methods for us... | 11/14/2006 |
| 7115601 | HIV integrase inhibitors Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating HIV infection and AIDS. ... | 10/03/2006 |
| 7087597 | Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof Compounds of the formula wherein R1, R2, R3, R4, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be use... | 08/08/2006 |
| 7087614 | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, Z, J and L are described herein, and analogs thereof are provided which are useful in treating T-ce... | 08/08/2006 |
| 7060827 | Intermediates useful for making 2,4-pyrimidinediamine compounds The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a... | 06/13/2006 |
| 7049318 | Substituted heterocyclic compounds and methods of use The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1,... | 05/23/2006 |
| 7037916 | Pyrimidine derivatives as IL-8 receptor antagonists Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q... | 05/02/2006 |
| 7026326 | Substituted heterocyclic compounds and methods of use The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3... | 04/11/2006 |
| 7022650 | 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines A description is given of 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines of formula (I) and of their use as herbicides. In this formula (I) R1, R2, R3 and R4 | 04/04/2006 |
| RE39056 | 4-Azasteroids for treatment of hyperandrogenic conditions Compounds of structural Formula (I) and pharmacologically acceptable salts and esters thereof possess 5α-reductase inhibitory activity. These compounds inhibit 5α-reductase type 1 and type 2. The compounds of structural Formula... | 04/04/2006 |
