|5008276||Methyl -(2-substituted)pyrid-3-yl-ଲ-methoxyacrylates, compositions containing them and their use as fungicides|
Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is O, S(O)n, NR4, CR1 R2...
An insecticidal compound of formula (I): ##STR1## wherein R1 and R3 are independently selected from hydrogen; halogen; nitro; cyano; or alkyl, alkoxy, alkylthio or cycloalkyl any of which can be optionally substituted by halogen...
|4988703||Carbocyclic nucleoside analogs with antiviral activity|
An antiviral compound of the formula: ##STR1## wherein A is selected from a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group and a heterocyclic isostere of a pyrimidin-1-yl group; and G and D are independently s...
|4983211||Substituted cyclohexanediones and their herbicidal use|
The present disclosure is directed to substituted cyclohexanedione compounds, the preparation of said compounds, compositions containing said compounds and the use of said compositions in the selective pre- and postemergent kill and control of grassy weed...
|4983608||N-substituted-4-pyrimidinamines and pyrimidinediamines|
This invention relates to N-heteroaryl-4-pyrimidinamines of the formula ##STR1## where R1 is hydrogen, loweralkyl, aryl, or arylloweralkyl; R2 and R3 are independently hydrogen or loweralkyl, or R2 and R
|4980355||Compositions for protecting plants against disease|
Novel substituted isonicotinic acid amides of the general formula ##STR1## in which X in ortho/ortho'-position are equal and represent fluorine, chlorine, bromine or iodine; Q1 is unsubstituted pyridimin-4-yl, or pyrimidin-4-yl substituted by ...
|4977263||Process for preparing 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials|
Antibacterially active new 1,8-bridged 4-quinolone-3-carboxylic acid derivatives of the formula ##STR1## in which Y is carboxyl or a derivative thereof R1, R2, R3, X1, X2 and X5 are H or va...
|4975434||Antiviral and anticancer cyclopentenyl cytosine|
Cyclopentenyl pyrimidine compounds have potent anti-viral, anti-tumor and differentiating activity. Of these compounds, cyclopentenyl cytosine has proved to be particularly effective in a variety of tumors, as well as having good antiviral activity and po...
|4975433||Aminomethyl derivatives of biologically active substances and enhanced delivery thereof across topical membranes|
A compound of the formula: ##STR1## wherein: R and R1 may be the same or different and are selected from the group consisting of H; cycloalkyl groups having up to 10 carbon atoms; or straight or branched chain alkyl, alkenyl or alkynyl of ...
|4970313||Optically active 3-demethylmevalonic acid derivatives, and intermediates|
A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic aci...
|4968340||Alkanoic acid derivatives and herbicidal compositions|
A herbicidal alkanoic acid derivative of the formula: ##STR1## wherein R is ##STR2## wherein R3 is a hydrogen atom, a halogen atom, a halogen-substituted alkyl group, an alkyl group, a cycloalkyl group, an alkylthioalkyl group, a...
|4968796||Preparation of sulphonylisothioureas|
Disclosed is a process for the preparation of a sulphonylisothiourea of the formula ##STR1## wherein R1, R2, R3, X, Y, and Z are as defined herein, which comprises reacting a sulphonic acid amide of the formula R...
|4968690||3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it|
The new compound 3-deazaneplanocin A has been discovered to have potent anti-viral, anti-tumor activity and differentiating activity. A simple method for preparing 3-deazaneplanocin A has been developed involving nucleophilic substitution, which method ca...
|4965357||2,5,6-substituted N1 -alkylpyrimidines|
The synthesis and application of N(1)-n-alkyl-pyrimidinium-salts are described. These surfactants have a very small critical micelle concentration (CMC) in the order of 10-5 -10-7 Mol/Liter. These N(1)-n-alkyl-pyrimidinium components...
|4960777||Heteroaryloxy-ଲ-carboline derivatives, their preparation and their use as medicinal agents|
Heteroaryloxy-ଲ-carboline derivatives of general Formula I ##STR1## wherein R1 is an optionally substituted heteroaryl residue, R2 is hydrogen, lower alkyl or lower alkoxyalkyl, X is a COOR3 -group wherein R3 m...
|4956366||Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations|
Substituted thienoimidazole derivatives, a process for the preparation thereof, pharmaceutical compositions containing them, and the use thereof as inhibitors of gastric acid secretion, as gastroprotectives and as medicaments for intestinal inflammations ...
|4954628||Process for preparing N-sulphonyl-ureas|
The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C1-4 alkyl, C1-4 ...
|4946956||Arylenediamine substituted pyrimidines|
Disclosed are novel 2,4,6 substituted pyrimidines where the substituents may be the same or different groups. At least one substituent must be N-alkyl parphenylenediamino, and the other substituents may be various radicals containing sulfur, oxygen or nit...
|4941910||Herbicidal pyrimidine derivatives|
Herbicidal pyrimidine derivatives of the formula ##STR1## in which R1 stands for optionally substituted alkyl, R2 stands for an optionally substituted radical from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, aryl, ara...
|4935427||Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents|
Compounds which are active against retroviruses have the following formula HOH2 C--CH.dbd.C.dbd.CH--B wherein B is a purine or pyrimidine heterocyclic ring which is preferably selected from the group consisting of cytosine, 5-halo substituted cytosi...
This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are...
|4929727||Improved process for precipitating cytosine from alkaline solutions with sulfuric acid|
The invention relates to an improved process for precipitating cytosine from an aqueous solution of an alkali or alkaline earth metal salt of cytosine using sulfuric acid....
N-(2,2-Dioxo-1,2-benzoxathiin-8-ylsulfonyl)-N'-pyrimidinylureas, N-(2,2-dioxo-1,2-benzoxathiin-8-ylsulfonyl)-N'-triazolylureas and N-(2,2-dioxo-1,2-benzoxathiin-8-ylsulfonyl)-N'-triazinylureas of the formula ##STR1## wherein R1 is hyd...
|4918075||Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents|
Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R2 and R3 are independently hydrogen, --PO3 H2 or ##STR2## and R1
|4916131||Naphthyridine derivatives and method for treating allergic reactions|
1-Substituted naphthyridines and pyrido-pyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and hyperproliferative skin diseases and in suppressing the immune response in mammals. Pharmaceutical composition...
|4914122||1-Aminomethyl-3-aryl-4-cyano-pyrroles, useful as fungicides|
Fungicidally active novel 1-aminomethyl-3-aryl-4-cyano-pyrroles of the formula ##STR1## in which Ar represents optionally substituted phenyl, R1 represents optionally substituted alkyl, represents alkenyl, alkynyl or cycloalkyl, or represe...
|4914203||5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas|
This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active i...
|4912109||N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds|
This invention pertains to novel substituted N-heterocyclic-N-(4-piperidinyl)amides useful as analgesics and antagonists of opiods, wherein the compounds have the general formula: ##STR1## including optically active isomeric forms, and the pharmaceut...
|4902795||Intermediates for 1,8-bridged 4-quinolone-3-carboxylic acid antibacterials|
Antibacterially active new 1,8-bridged 4-quinolone-3-carboxylic acid derivatives of the formula ##STR1## in which Y is carboxyl or a derivative thereof R1, R2, R3, R4, X1, X2 and X5
|4900828||Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine|
A method for the synthesis of 2',3'-dideoxycytidine comprising a novel procedure of bromoacetylating cytidine to yield novel intermediates which are subsequently reduced and hydrogenated by novel procedures to yield 2',3'-dideoxycytidine....
The invention relates to certain sulfonylurea compounds having an ester group ortho to the sulfonylurea linkage which have been found to be excellent preemergent and postemergent herbicides or plant growth regulators....
Herbicidal triazole sulphonamides of the formula: ##STR1## and salts thereof, where: R1 represents hydrogen or a substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, acyl, alkoxycarbonyl, aminocarbonyl, sulphony...
Compounds are described of formula (I) ##STR1## wherein R1 is a hydrogen atom, an alkyl group, an alkoxy group, a dialkylamino group or a halogen atom; n is 1 to 4; R2 is a hydrogen atom, an alkyl group, an unsubstituted or subs...
|4886817||Imidazolidinones as brain activators|
This invention relates to imidazolidinone compounds of the formula ##STR1## wherein Q is methylene group or a single bond: R is a heterocyclic group selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl and 1,3-thiazolyl which...
This application relates to ortho-carboxylate ester sulfonylureas which are useful as agricultural chemicals and in particular have high herbicidal activity while showing tolerance to certain crops....
|4879292||Certain-phenoxy-phenoxy-alkylene-oxy-pyrimidines or symmetrical triazines, thio-analogues thereof, having insecticidal activity|
A nitrogen-containing heterocyclic compound of the formula: ##STR1## wherein R1 is either one of the following groups: ##STR2## (in which R7, R8, R9, R10, R11, R12, R
Cognitive deficiencies and/or neurological function deficits and/or mood and/or mental disturbances are treated by the administration of 3,3-disubstituted indolines. The indolines have the formula: ##STR1## wherein: p is 0 or 1; Z is O or S; R is C
|4871387||Pyri(mi)dyl-oxy-and -thio-benzoic acid derivatives useful as herbicides and plant growth regulants|
New pyri(mi)dyl-oxy- or -thio-benzoic acid derivatives of the formula ##STR1## are taught which have herbicidal and plant growth regulating activity. In the formula Z can be Ch or N, X is oxygen or sulphur, A is oxygen, sulphur, a radical R5
|4868187||Anti-viral N-substituted pyrimidines|
Nucleoside analogues having a ring-open structure, of general formula: ##STR1## where R and R' may be hydrogen, silyl groups, substituted alkyl groups, benzyl groups and the like, and X is an optionally substituted base such as guanine or adenine, ha...
|4866061||Aryl-substituted naphthyridine and pyridopyrazine derivatives|
Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such comp...