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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 6197750 | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients su... | 03/06/2001 |
| 6194413 | Hemoregulatory compounds The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.... | 02/27/2001 |
| 6180627 | Antithrombotic agents Compounds of formula (I): ##STR1## Are antithrombotic agents, having utility in a variety of therapeutic areas including the prevention and/or treatment of deep vein thrombosis (DVT) after surgery, major medical illness, paralysis, malignancy, prolonged ... | 01/30/2001 |
| 6174901 | Substituted pyridine and pyridazine compounds and methods of use Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The inventio... | 01/16/2001 |
| 6172066 | Dihydropyrimidines and uses thereof This invention is directed to dihydropyrimidine compounds which are selective antagonists for human receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthes... | 01/09/2001 |
| 6172227 | 4,5-diaminopyrimidine derivatives and a method for the preparation thereof Novel 4,5-diamino pyrimidine derivatives are described by the following general formula I: ##STR1## in which X is a direct bond, C1-4 alkylene, C1-4 alkyleneoxy, C1-4 alkoxyphenyl or phenyl C1-4 alkylene; Y is a... | 01/09/2001 |
| 6169086 | Pyrazole derivatives The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): ##STR1## wherein G represents a nitrogen containing saturated heterocyclic structure ... | 01/02/2001 |
| 6166027 | Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.... | 12/26/2000 |
| 6166020 | Aryl and heteroaryl alkoxynaphthalene derivatives Compounds of the formula ##STR1## wherein R1, R2, R4, R23, R24, R25 and R26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent sero... | 12/26/2000 |
| 6162809 | Pyridylthio compounds for controlling helicobacter bacteria Pyridinylthiomethyl- and pyrimidinylthiomethyl-pyridines and their pharmacologically-acceptable compositions are useful for controlling Helicobacter bacteria and for treating those afflicted with diseases based on Helicobacter bacteria.... | 12/19/2000 |
| 6159995 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 12/12/2000 |
| 6159980 | Pyrazinones and triazinones and their derivatives thereof Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear pa... | 12/12/2000 |
| 6153613 | 2,3-diketopiperazine derivatives or their salts The present invention relates to a 2,3-diketopiperazine derivative or a salt thereof, which has inhibitory effect on platelet aggregation because of glycoprotein IIb/IIIa receptor antagonism and hence is useful as a prophylactic and therapeutic agent for ... | 11/28/2000 |
| 6150356 | Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds... | 11/21/2000 |
| 6147078 | Pyrazinone thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein ##STR2##... | 11/14/2000 |
| 6143892 | Process for making 5-substituted pyrazoles This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.... | 11/07/2000 |
| 6143750 | Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds ... | 11/07/2000 |
| 6143744 | Sulfamide-metalloprotease inhibitors This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 11/07/2000 |
| 6136971 | Preparation of sulfonamides The present invention provides a process for preparing 1,2-diheteroethylene sulfonamide of the formula: ##STR1## by reacting a pyrimidine monohalide of the formula: ##STR2## with a mono-protected 1,2-diheteroethylene anion of the formula M1... | 10/24/2000 |
| 6133268 | 1,4-disubstituted piperazines The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ... | 10/17/2000 |
| 6130215 | Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the novel compounds The invention refers to novel piperazinylalkylthiopyrimidine derivatives of formula (I) being suitable for the treatment of diseases due to pathological alterations of the central nervous system, pharmaceutical compositions containing the above derivative... | 10/10/2000 |
| 6127357 | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as anxiolytics. In the formula A is ... | 10/03/2000 |
| 6124306 | Thioalkyl alpha substituted pyrimidine compounds The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R4 is selected from the group consisting of --H or --NR15 R16... | 09/26/2000 |
| 6124294 | Triazole compounds and the use thereof The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 re... | 09/26/2000 |
| 6114342 | 2-(O-[pyrimidin-4-yl]methylenoxy)phenylacetic acid derivatives and their use for controlling harmful fungi and animal pests 2-(O-[pyrimidin-4-yl]methylenoxy)phenylacetic acid derivatives of the general formula I and the salts and N-oxides thereof where the radicals R1 to R4 and Q have the following meanings: R1 is hydrogen or alkyl; R2 is... | 09/05/2000 |
| 6114334 | Piperazine derivatives as therapeutic agents Substituted piperazine compounds of formula I ##STR1## in which HET is a substituted pyrazole, imidazole or 1,2,4-triazole have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schi... | 09/05/2000 |
| 6114333 | 2-Pyrimidineamine derivatives and processes for their preparation Compounds of general formula (1) ##STR1## are described wherein: Ar is an optionally substituted aromatic group; R2 is a hydrogen or halogen atom or a group --X1 --R2a where X1 is a direct bond or a linker atom ... | 09/05/2000 |
| 6110924 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds Compounds of formula I, useful as matrix metalloprotease inhibitors, ##STR1## wherein X, Y and Z are each oxygen; R1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and (d) (4-phenoxy)phenyl, wherein the terminal... | 08/29/2000 |
| 6103719 | Neurokinin antagonists, processes for preparing them and pharmaceutical compositions containing these compounds The invention relates to new compounds of general formula I ##STR1## or the pharmaceutically acceptable salts thereof, wherein X=N--R3 or CH--R4, Y=CH2 or (CH2)2, Z=O or H2 ; and R1 | 08/15/2000 |
| 6100265 | Thiopyran derivatives A thiopyran derivative represented by the following formula (I) or (I'), or the salt thereof. ##STR1## wherein A is S or --CH.dbd.CH--; the dotted line indicates that the bond may be either present or absent; Z and Z' are typically ##STR2## ... | 08/08/2000 |
| 6096753 | Substituted pyrimidinone and pyridone compounds and methods of use Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-, IL-1ଲ, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention enco... | 08/01/2000 |
| 6093718 | Substituted pyrimidine derivatives and their pharmaceutical use This invention concerns heterocyclic derivatives which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocyclic derivatives ... | 07/25/2000 |
| 6093717 | Imidazopyridine thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein Y1 and Y2 are independently selected from the group consisting of hydrogen, C | 07/25/2000 |
| 6093716 | Substituted 2-pyrimidineamines and processes for their preparation Compounds of general formula (1): ##STR1## are described wherein Het is an optionally substituted heteroaromatic group; R1 is a hydrogen atom or a straight or branched chain alkyl group; R2 is a hydrogen or halogen atom or a gro... | 07/25/2000 |
| 6090809 | 1-(4-arylpiperazin-1-yl)-ω-[n-(.. omega.-dicarboximido)]-alkanes useful as uro-selective 1 -adrenoceptor blockers Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective adrenergic activi... | 07/18/2000 |
| 6083950 | 1-(4-arylpiperazin-1-yl)-ω-[n-(,ω-dicarboximido)]-alka nes useful as uro-selective 댑-adrenoceptor blockers Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective adrenergic activi... | 07/04/2000 |
| 6080738 | Heterocyclic amide compounds and medicinal uses thereof A heterocyclic amide compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and a pharmaceutical use thereof. The heterocyclic ami... | 06/27/2000 |
| 6069251 | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4- substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## wherein R1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R3 and R4 | 05/30/2000 |
| 6066637 | Indolyl derivatives as serotonergic agents The present invention provides compounds represented by the general formula (1) wherein R1 is selected from H, OH, OR2 or halogen (F, Cl, Br, I); R2 is lower alkyl (C1 to C6); n is selected from 0, 1 or 2; X is... | 05/23/2000 |
| 6057304 | Quinoxaline-phosphonic acid derivatives The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R1, R4, R5, R6, R7 and R8 are as defined in the disclosure, as well as their production and use in medic... | 05/02/2000 |
