Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 5889006 | Muscarinic antagonists Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R1, R2, R3, R4, R21, R... | 03/30/1999 |
| 5889012 | Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides Substituted cycloalkylamino and cycloalkoxy heterocycles, processes for preparing them and their use as pesticides The invention relates to (I) ##STR1## in which R1 to R5, A, X, E, U, p and n are as defined in claim 1, to proces... | 03/30/1999 |
| 5883096 | Muscarinic antagonists Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds of formula I ##STR1## wherein one of Y and Z is N and the other is N, CH, or C-alkyl; X is --O--, --SO0-2 --, amino, substituted amino, --CO--, --CH2 --, mon... | 03/16/1999 |
| 5877317 | Heterocyclic compounds for the treatment of CNS and cardiovascular disorders Novel aromatic bicyclic amines of formula (I) ##STR1## are useful in treating central nervous system disorders and cardiac arrhythmias and cardiac fibrillation.... | 03/02/1999 |
| 5877174 | 2,3-diketopiperazine derivatives or their salts The present invention relates to a 2,3-diketopiperazine derivative or a salt thereof, which has inhibitory effect on platelet aggregation because of glycoprotein IIb/IIIa receptor antagonism and hence is useful as a prophylactic and therapeutic agent for ... | 03/02/1999 |
| 5872136 | Arylheteroaryl inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 02/16/1999 |
| 5872125 | Polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it It comprises the new polymorphs I and II of Lesopitron dihydrochloride, characterized by their infrared spectra and their X-ray diffraction patterns. They are obtained by crystallization of Lesopitron dihydrochloride. It also comprises the forms I-hydrate... | 02/16/1999 |
| 5869490 | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one The compounds of formula I: ##STR1## wherein X is H2 or O; R1 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or di-alkylamino, alkanamido or alkanesulfonamido; Z... | 02/09/1999 |
| 5866568 | Heterocyclic compounds The invention concerns pharmaceutically useful compounds of the formula I, in which A1, A2, A3, A4, B1, m, Ar, W, X, Y, Z and R1 have any of the meanings defined herein, and their pharmaceu... | 02/02/1999 |
| 5866583 | Substituted 2,4-diaminopyrimidines Compounds of formula I ##STR1## wherein R1 is lower-alkoxy, R2 is bromine, lower-alkoxy or hydroxy, R3 is hydrogen, lower-alkyl, cycloalkyl, aryl, heterocyclyl, aralkyl, heterocyclyl-lower-alkyl or cyano, R4 | 02/02/1999 |
| 5859014 | Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as 1 -adrenergic receptor antagonists Compounds of Formula I: ##STR1## where R5 is a group selected from Formulae (a), (b), (c) and (d): ##STR2## and the pharmaceutically acceptable salts and N-oxides thereof, are 댑 -adrenergic receptor antagonists usefu... | 01/12/1999 |
| 5859009 | Substituted spiroalkylamino and alkoxy heterocycles, processes for their preparation, and their use as pesticides and fungicides Substituted spiroalkylamino and -alkoxy heterocycles, processes for their preparation, and their use as pesticides and fungicides The invention relates to compounds of the formula ##STR1## in which Het is optionally substituted 4-pyridyl or 4-pyrimidinyl;... | 01/12/1999 |
| 5856484 | Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity Compounds of formula I: ##STR1## are disclosed. The compounds inhibit the binding of endothelin to its receptors.... | 01/05/1999 |
| 5854179 | Sulfur-substituted phenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Sulfur-substituted phenylsulfonylureas; processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1## in which R*, R1, R2, R3, X, Y, Z, W, n... | 12/29/1998 |
| 5852019 | Pyrimidinylpyrazole derivatives The present invention provides a novel compound which is represented by formula (I): ##STR1## wherein preferable examples of R1 to R6 are as follows; R1 and R2 are each an alkyl group optionally substituted... | 12/22/1998 |
| 5852031 | 2,7-substituted octahydro-1H-pyrido1,2-a!pyrazine derivatives Substituted pydrido1,2-a!pyrazines of general formula I wherein Ar and Ar1 represent various carbocyclic and heterocyclic aromatic rings; A represents O, S, SO, SO2, C.dbd.O, CHOH, or --(CR3 R4) and n is 0-2 a... | 12/22/1998 |
| 5849666 | N-substituted hydrazinophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulations N-substituted hydrazinophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) or salts thereof ##STR1## in which R1 to R6, W, Q, X, Y and Z are define... | 12/15/1998 |
| 5846965 | 3-aza and 3-oxa piperidone tachykinin antagonists Compounds of the formula: ##STR1## wherein: X is O, NH or NR1 ; R1 is C1 -C6 alkyl, C3 -C7 cycloalkyl, C3 -C7 cycloalkyl(C1 -C4)alkyl, aryl ... | 12/08/1998 |
| 5837708 | Sulphonamides Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, ... | 11/17/1998 |
| 5824624 | Herbicidal 2-(hectero)aryloxy-6-arypyridines and 2-aryl-4-(hetero)aryloxypyrimidines New herbicidal pyridine and pyrimidine derivatives of general formula (I), ##STR1## wherein Z represents a nitrogen atom or a C--H group; A represents an optionally substituted aryl group or an optionally substituted 5- or 6-membered nitrogen-contain... | 10/20/1998 |
| 5814642 | Tetracyclic condensed heterocyclic compounds their production, and use A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R1 represents H or a hydrocarbon group which may be substituted; Y represents an amino acid or nitrogen-contain... | 09/29/1998 |
| 5811426 | Urea and thiourea derivatives of azolones The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is CH or N; R1, R2 and R3 | 09/22/1998 |
| 5807859 | Imidazo (1,2-A)-Indeno (1,2-E) pyrazin-4-one derivatives and pharmaceutical compositions containing same Pharmaceutical compositions containing, as the active principle, compounds of formula (I): ##STR1## wherein R, R1 and R2 are as defined in the description, or salts thereof, the novel compounds of formula (I), and the preparatio... | 09/15/1998 |
| 5807860 | Urea derivatives A compound represented by formula (I) and a salt thereof, and a hydrate and solvate thereof: ##STR1## wherein R1, R2 and R3 represent independently, for example, hydrogen atom, hydroxyl group, or C1-3 alkox... | 09/15/1998 |
| 5808067 | Process for preparing pyridine and quinoline derivatives The present invention pertains to a method of preparing substituted and unsubstituted N-hydroxy-2-aminobutane diacid derivatives which can be dehydrated to 2-aminobut-2-ene dioic acid derivatives, which can be subsequently converted to pyridine and quinol... | 09/15/1998 |
| 5795894 | Piperazino derivatives as neurokinn antagonists The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.... | 08/18/1998 |
| 5795890 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 08/18/1998 |
| 5789410 | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands Disclosed are compounds encompassed by the following general formula: ##STR1## wherein, A represents ethenylene, or A represents --X--CH2 --; where X is carbon or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membere... | 08/04/1998 |
| 5786355 | 4,6-diarylpyrimidine derivatives and salts thereof Described are a 4,6-diarylpyrimidine derivative represented by the following formula (1): ##STR1## wherein R represents a heterocyclic ring which may be substituted by one to four lower alkyl groups or an amino group and Ar represents a phenyl, ... | 07/28/1998 |
| 5783576 | Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.... | 07/21/1998 |
| 5780474 | 3-(piperid-4-yl)-1,2-benzisoxazole and 3-(piperazin-4-yl)-1,2-benzisoxazole compounds Compounds of formula: ##STR1## wherein: A, m, n, E and Y are as defined in the description, the optical isomers thereof and the physiologically-tolerable salts thereof. These compounds, their optical isomers and their physiologically-tolerable salts,... | 07/14/1998 |
| 5779934 | Fluorine-containing optically active compound, process for preparing the same and liquid crystal mixture and liquid crystal element comprising the same A fluorine-containing optically active compound represented by the formula (1): ##STR1## wherein R1 is a saturated or unsaturated C3 -C20 alkyl group or a saturated or unsaturated C3 -C20 alkoxya... | 07/14/1998 |
| 5777114 | Spiroheterocycle-imidazo1,2-a!indeno1,2-e!pyrazine!-4'-ones, preparation thereof and drugs containing same Compounds of formula (I): ##STR1## wherein R3 and R4, taken together with the carbon atom to which they are attached, form (a) a 2- or 3-pyrrolidine ring, a 2- or 4-piperidine ring or a 2-azacycloheptane ring, said rings being o... | 07/07/1998 |
| 5776858 | 1-azinyl-tetrazolinones 1-Azinyl-tetraozolinones of the following formulae (I) and (II): ##STR1## wherein R1 and R2 are independently represent alkyl, haloalkyl, cycloalkyl, alkenyl, haloalkenyl, alkynyl or optionally substituted phenyl, or R1 | 07/07/1998 |
| 5776941 | 4-alkylthio-pyrimidin-5-ylacetic acid derivates This invention relates to 2-(4-alkylthio-pyrimidin-5-yl)-acetic acid derivatives; fungicidal compositions comprising such compounds and a method of combating phytopathogenic fungi comprising applying such compounds to the fungi or their habitat.... | 07/07/1998 |
| 5776963 | 3-(heteroaryl)-1-(2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1-(2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 07/07/1998 |
| 5773445 | 3-methoxy-phenyl-acrylic acid methyl esters The application describes new 3-methoxy-2-phenyl-acrylic esters of the formula (I) ##STR1## in which R and Y have the meanings given in the description, a process for their preparation, and their use as pesticides.... | 06/30/1998 |
| 5773616 | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands Disclosed are compounds encompassed by the following general formula: ##STR1## wherein, A represents ethenylene, or A represents --X--CH2 --; where X is carbon or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membere... | 06/30/1998 |
| 5767141 | Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the meanings stated in the description, a process for the pre... | 06/16/1998 |
| 5763609 | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4 are the same or different and represent hydrogen, C1 -C | 06/09/1998 |
