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| Number | Title | Issue Date |
| 4728644 | Purine derivative and pharmaceutical composition Purine derivatives of the formula: ##STR1## wherein R is hydrogen, alkyl or phenyl which may be substituted by at least one halogen, lower alkyl or lower alkoxy; each of R1 and R2 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, di... | 03/01/1988 |
| 4720497 | 6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, ##STR1## in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula ... | 01/19/1988 |
| 4718936 | 6-(3-thienylmethylamino)-purine, its preparation and its use 6-(3-Thienylmethylamino)-purine of the formula ##STR1## a process for its manufacture, and agents for regulating plant growth containing a compound of the formula I.... | 01/12/1988 |
| 4714701 | Antiviral compounds Compounds of formula (I) ##STR1## (wherein A represents a ##STR2## grouping; R1 represents a hydrogen or halogen (e.g. chlorine or bromine) atom or a hydroxy or amino group, R2 represents a hydrogen atom or a C1-4... | 12/22/1987 |
| 4707550 | N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are general vasodilating agents and anti-hypertensive agents. The compounds are usef... | 11/17/1987 |
| 4701526 | Process for preparing 9-(2-hydroxyethoxymethyl)-guanine, and intermediates useful in said process There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV ##STR1## wherein a novel compound of the formula I ##STR2## wherein R and R' may be the same or different and represent hydrogen, (C | 10/20/1987 |
| 4684728 | Solubilizing biologically active compounds with reactive hydrogen atoms A biologically active compound can be solubilized by reaction in different sequences to form a derivative carrying the active moiety, a linking group such as an optionally substituted diisocyanate radical, a polyether moiety such as a polyoxyethylene radi... | 08/04/1987 |
| 4678789 | Triazole antifungal agents Compounds of the general formula: ##STR1## wherein Ar is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and Het is a heterocyclic group which may optionally be substituted or fused to a phenyl, substituted phenyl or further ... | 07/07/1987 |
| 4670438 | Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents Compounds of the formula ##STR1## wherein A, B, C and D are --N.dbd., HN.dbd., R3 N.dbd., O.dbd.C.dbd., HC.tbd., HO--C.tbd. or R3 SO2 --O--C.tbd.; and R1 and R2 are substituents of various types. The ... | 06/02/1987 |
| 4649140 | Purine derivatives The novel compound 6-deoxyacyclovir, which itself has antiviral activity against herpes viruses, is converted enzymatically to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxygenase.... | 03/10/1987 |
| 4642346 | Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine Novel anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine useful as an antiviral agent.... | 02/10/1987 |
| 4634706 | Griseolic acid derivatives, and their use as enzyme inhibitors Griseolic acid derivatives of formula (I): ##STR1## wherein A represents: ##STR2## have enzyme-inhibitory activity, especially against cAMP PDE and cGMP PDE. When formulated as compositions with appropriate carriers or diluents, they may be... | 01/06/1987 |
| 4621140 | Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives Process and novel intermediates for preparing 9-(1,3-dihydroxy-2-propoxymethyl)guanine and 2,6-diamino-9-(1,3-dihydroxy-2-propoxymethyl)purine and certain esters thereof. The present process and intermediates reduce the number of reaction steps to pr... | 11/04/1986 |
| 4617304 | Purine derivatives Purines and pyrimidines having a fused cyclopropane ring in the side chain and the heterocyclic isosteres of said purines and pyrimidines have antiviral activity, especially against viruses of the herpes class.... | 10/14/1986 |
| 4612314 | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R1 and R2 are both --C(O)R7 wherein R7 is 1-adamantyl; ... | 09/16/1986 |
| 4609662 | Method for using purine derivatives The novel 2-aminopurine derivatives disclosed herein which have a hydrogen atom in the 6-position and an acyclic chain ##STR1## in the 9-position [wherein X=O or S, Y=H or CH2 OR and R=H or ##STR2## wherein R°=H, C1-16 alk... | 09/02/1986 |
| 4609661 | Substituted 9-(1-O- or 3-O-monosubstituted or 1,3-di-O-substituted propoxymethyl)purines as antiviral agents Compounds useful as antiviral agents are defined by the following formula: ##STR1## wherein R1 is hydrogen, --C(Y)OR7 or --C(O)NHR7 wherein R7 is alkyl of one to twelve carbon atoms, alkenyl of two to twelve ... | 09/02/1986 |
| 4603219 | 1,3-dibenzyloxy-2-acetoxymethoxypropane, intermediate for 9-(1,3-dihydroxy-2-propoxymethyl)guanine The compounds 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents. The compound 1,3-dibenzyloxy-2-acetyloxy-methoxypropane is useful as an intermediate for the preparation of 9-(1,... | 07/29/1986 |
| 4602089 | Process for preparing purine compounds There are prepared compounds of the formulae ##STR1## where R is lower alkyl, chlorine, or bromine and n is an integer from 1 to 5. The compounds of formula (1) can be used to make erythro-9-(2-hydroxy-3-nonyl) hypoxanthine and its homologues and als... | 07/22/1986 |
| 4594321 | Process for producing 3-deoxyguanosine Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of micr... | 06/10/1986 |
| 4594320 | Process for producing 3-deoxyguanosine Glycosylation or transglycosylation of a specified guanine derivative, namely 9-substituted or non-substituted guanine of formula [I] with a 3-deoxyribose donor such as 3'-deoxyadenosine in the presence of a nucleoside phosphorylase source such as of micr... | 06/10/1986 |
| 4590269 | Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines An improved process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines which are useful as antiviral agents.... | 05/20/1986 |
| 4579849 | N-alkylguanine acyclonucleosides as antiviral agents Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R1 and R2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, each having 1 to 19 carbon at... | 04/01/1986 |
| 4567182 | Compounds endowed with immunomodulating activity The invention relates to a series of purine derivatives of formula (I) ##STR1## wherein R is hydrogen or NH2, n is an integer from 1 to 6, R1 is one of the following chains: ##STR2## wherein R2 is the residue of ... | 01/28/1986 |
| 4565868 | Process for preparing guanine derivatives 1-Monophosphate esters, 1,3-bisphosphate esters and cyclic phosphate esters of 9-(1,3-dihydroxy-2-propoxymethyl)guanine are useful as antiviral agents.... | 01/21/1986 |
| 4556659 | Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents Compounds useful as antiviral agents are defined by the following formula: ##STR1## wherein R1 is hydrogen, --C(Y)OR7 or --C(O)NHR7 wherein R7 is alkyl of one to twelve carbon atoms, alkenyl of two to twelve ... | 12/03/1985 |
| 4551277 | 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid Antibacterial activity is exhibited by (3-acylamino)-2-azetidinones having in the 1-position a group of the formula ##STR1## or a salt or ester thereof wherein R5 and R6 are the same or different and each is hydrogen or alkyl.... | 11/05/1985 |
| 4548819 | Derivatives of 9-(2-hydroxyethoxymethyl) guanine Compounds of the general formula ##STR1## (wherein X represents an oxygen or sulphur atom, R1 represents a hydroxy or amino group, R2 represents a hydrogen atom or a group of formula --CH2 OR3a a... | 10/22/1985 |
| 4543255 | Carbocyclic analogs of purine 2'-deoxyribofuranosides There are disclosed carbocyclic analogs of 2-amino-6-substituted-purine 2'-deoxyribofuranosides and 2-amino-6-substituted-8-azapurine 2'-deoxyribofuranosides. The compounds are useful in the treatment of viral infections.... | 09/24/1985 |
| 4507305 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 03/26/1985 |
| 4495190 | Derivatives of guanine for combating herpes virus infections Novel antiviral compounds of the formula ##STR1## wherein each of R1 and R2, which are the same or different is hydrogen, hydroxy or fluoro; provided that R1 or R2 is hydrogen when R1 and R2... | 01/22/1985 |
| 4473571 | 8-Substituted-2-(4-pyridinyl)-9H-purin-6-amines and their cardiotonic use 8-Q-2-PY-9H-purin-6-amines (II), salts thereof, their preparation and cardiotonic use are shown, where PY is 4-pyridinyl or 4-pyridinyl having one or two lower-alkyl substituents, and Q is methyl, ethyl, 1-methylethyl, 1,1-dimethylethyl, methylthio and et... | 09/25/1984 |
| 4461757 | Dimethylaminomethylenated anti-herpes compounds 2-(N,N-dialkylaminomethylene)-9-[[2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl ]guanine either alone or in admixture with interferon is active in treatment of herpes simplex type 1 viral infections.... | 07/24/1984 |
| 4460690 | Stimulation of viral growth rate The novel nucleoside analogue 9-[1-(1,3-diacetoxy-2-propoxy)-2-acetoxy]ethylguanine has the effect of stimulating the rate of growth of certain viruses, particularly influenza viruses, so that culturing virally infected cells in the presence of this ... | 07/17/1984 |
| 4443435 | Prodrugs of 6-mercaptopurine and 6-mercaptopurine ribosides and therapeutic compositions and methods employing them Novel, transient prodrug forms of biologically active agents containing mercapto groups have (i) the structural formula (I): ##STR1## wherein X is O, S, or NR5 ; R1 S is the residue of any biologically active agent R1 SH; ... | 04/17/1984 |
| 4442290 | Development restrainer release compounds There are described novel compounds which are represented by the formula ##STR1## wherein R is ##STR2## A is sulfur or selenium; X represents the nonmetallic atoms necessary to form a nucleus which completes a five or six membered heterocyclic m... | 04/10/1984 |
| 4423050 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 12/27/1983 |
| 4419358 | Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it This invention concerns an isethionic acid addition salt of the non-adrenergic bronchodilating agent 9-cyclohexyl-2-propoxy-9H-purine-6-amine. The salt is comprised of a 2:1 molecular ratio of the isethionic acid to the adenine base. The salt of the ... | 12/06/1983 |
| 4360522 | Purine derivatives 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the c... | 11/23/1982 |
| 4355032 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 10/19/1982 |
