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| Number | Title | Issue Date |
| 4372959 | 1-(5-Oxohexyl)-3-alkyl-7-(2-oxopropyl)xanthines Compounds of the formula (I): ##STR1## wherein R is C1-4 alkyl, pharmaceutical compositions containing them and a process for their preparation. The compounds are useful for the treatment of peripheral vascular diseases in mammals.... | 02/08/1983 |
| 4334069 | Chemiluminescent phthalhydrazide-labeled hapten conjugates Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R1 and R2 is hydrogen and the other is --NR3 R4 ; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms an... | 06/08/1982 |
| 4302438 | Antigen, antiserum and immunoassay for theophylline By injecting a host animal with a member of a particular group of antigens [a theophylline-(7)-alkanecarboxylic acid covalently bonded to an immunogenic carrier (IGC) via the carboxyl group], antibodies, advantageously employed in determining small amount... | 11/24/1981 |
| 4291037 | 7-(Oxoalkyl)-1,3-di-n-iso-propyl xanthines and their production 7-(Oxoalkyl)-1,3-dialkyl xanthines whose substituents in the 1- and 3-positions are alkyl groups of 2 to 6 carbons, cyclohexyl, alkoxyalkyl or hydroxyalkyl, such as 7-(3-oxobutyl)-1,3-di-n-butylxanthine, are effective vasodilators, having a marked activit... | 09/22/1981 |
| 4289776 | Xanthine derivatives Compounds of general formula ##STR1## wherein one of the groups R1 and R3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is se... | 09/15/1981 |
| 4275064 | Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents Compounds of the formula: ##STR1## useful in treating dermal inflammation in warm-blooded animals are provided.... | 06/23/1981 |
| 4242345 | 7-(Oxoalkyl)-1,3-dialkyl xanthines, and medicaments containing them 7-(Oxoalkyl)-1,3-dialkyl xanthines whose substituents in the 1- and 3-positions are alkyl groups of 2 to 6 carbons, cyclohexyl, alkoxyalkyl or hydroxyalkyl, such as 7-(3-oxobutyl)-1,3-di-n-butylxanthine, are effective vasodilators, having a marked activit... | 12/30/1980 |
| 4223031 | Azolopyrimidinones 6-(1H-Tetrazol-5-yl)thiozolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo-pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue o... | 09/16/1980 |
| 4156081 | Theophylline antigens and antibodies Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for producti... | 05/22/1979 |
| 4153803 | Cholesterol-lowering phenoxyalkanoic acid esters Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing fro... | 05/08/1979 |
| 4120947 | Xanthine compounds and method of treating bronchospastic and allergic diseases Bronchial asthma and other bronchospastic and allergic diseases are treated by administering an effective amount of a substituted xanthine compound having the formula: ##STR1## wherein: R1 = C1 -C3 alkyl, R3 | 10/17/1978 |
| 4071517 | Soluble salts containing sulphur A double salt comprising a material obtained by heating a mixture of equi-molar proportions of a theophylline alkanoic acid having the formula: wherein R1 is a theophyllyl group which may be substituted by a halogen atom and n is an integer from 1--... | 01/31/1978 |
| 4061753 | Treating psoriasis with transient pro-drug forms of xanthine derivatives Compounds of the formula: ##STR1## wherein R, which may be the same or different, represents a member selected from the group consisting of --CH3, --C2 H5, --C3 H7, iso--C3 H7 | 12/06/1977 |
| 4060617 | Esters of the ophyllinylacetic acid A compound of the formula ##STR1## wherein R is hydrogen or methyl, n is a number from 1 to 4 and `Acyl` is nicotinoyl, 3-methylpyrazole-5-carboyl, 3-methyl-isoxazolyl-5-carboyl, 5-n-butylpyridin-2-carboyl, 2-(4-chlorophenoxy)-2-methyl-propionyl, ... | 11/29/1977 |
| 4035366 | 1-Benzal-1,2,3,4-tetrahydro-isoquinolinium-theophylline-7-acetates 1-Benzal-1,2,3,4-tetrahydro-isoquinolinium-theophylline-7-acetates are used in the manufacture of geriatric compositions.... | 07/12/1977 |
| 4021485 | N,N'-bis-[(ଲ-hydroxy-ଲ-phenyl)-ethyl]-polymethylenediamines and salts thereof Compounds of the formula ##STR1## WHEREIN R1 is hydrogen or methyl, m is 0 or an integer from 1 to 8, inclusive, and Ar is ##STR2## WHERE R is hydrogen or acyl, and R2 is hydrogen or --OR, as defined above, ##STR3## ... | 05/03/1977 |
| 4010158 | 1-(2'-Ethynyl-phenoxy)-2-hydroxy-3-butylamino-propanes and salts Compounds of the formula ##STR1## wherein R is secondary butyl or tertiary butyl, and their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as their salts are useful as ଲ-adrenergic receptor blocking agents an... | 03/01/1977 |
| 4000132 | Method for synthesizing certain selected pro-drug forms of theophylline There is provided, a method for synthesizing certain selected pro-drug forms of theophylline, having the formula: ##STR1## wherein R represents a member selected from the group consisting of a straight or branched C4 -C20 alkyl ... | 12/28/1976 |
| 3984413 | Phenoxyalkanecarboxylic acid esters of hydroxyalkyltheophyllines and method for their manufacture Phenoxyalkanecarboxylic acids are esterified with 7-(2-hydroxyethyl) theophylline or 7-(2,3-dihydroxypropyl) theophylline. The resulting esters have excellent antilipemic and anticholesterolemic properties as well as pronounced peripheral and vasodilative... | 10/05/1976 |
| 3975525 | N-[4'-Imidazolidinon-(2)-yl-phenethyl]-N'-pyridyl-piperazines and salts thereof Compounds of the formula ##SPC1## Wherein R1 is hydrogen or hydroxyl, and Py is pyridyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as CNS-depressants, neuroleptics and... | 08/17/1976 |
| 3969410 | 1-(2'-Alkyl-3',4'-dihydroxy-phenyl)-2-(phenylalkyl-amino)-alkanols-(1) and salts thereof Compounds of the formula ##SPC1## Wherein R1 is alkyl of 1 to 5 carbon atoms, R2 is hydrogen or lower alkyl, R3 is hydrogen or hydroxyl, and Z is alkylene of 2 to 6 carbon atoms, And non-toxic, pharmacologically acceptable acid addi... | 07/13/1976 |
| 3966814 | 1-Phenyl-2-(Naphthylalkyl-amino)-ethanols and salts thereof Compounds of the formula ##SPC1## Wherein A is alkylene of 2 to 6 carbon atoms, R1 is hydrogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, R2 is hydrogen, lower alkyl or lower alkoxy, R3 is hydrogen, methyl or e... | 06/29/1976 |
| 3954872 | 1-(2',6'-Dimethyl-phenoxy)-2-amino-alkanes and salts thereof Compounds of the formula ##EQU1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms, and R1 is hydrogen or methyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as a... | 05/04/1976 |
| 3937708 | N-phenyl-imidazolidine-1-ones Compounds of the formula ##SPC1## Wherein R is hydrogen, halogen, lower alkyl or lower alkoxy, R' is --CHR1 --Q--A, --CHR2 --A or --O--CHR2 --CHR1 --Q--A, each in m- or p-position, Where A is ##SPC2## Q is strai... | 02/10/1976 |
| 3935196 | Useful pro-drug forms of theophylline There is provided novel and useful pro-drug forms of theophylline having the formula: ##SPC1## Wherein R represents a member selected from the group consisting of a straight or branched C4 -C20 alkyl group, a straight or branched ... | 01/27/1976 |
