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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 6919449 | Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one... | 07/19/2005 |
| 6734143 | 2-methoxyimino-2(pyridinyloxymethyl)phenyl acetamides useful as fungicides The present invention provides 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides according to formula (I) as well as their use as fungicidal compounds. ... | 05/11/2004 |
| 6531484 | Pyrrolidine modulators of CCR5 chemokine receptor activity Pyrrolidine compounds of Formula I: ##STR1## (wherein R1, R2, R3, R4, R5, R6, R7, R8a, R8b, j, k, 1, m, and n are defined herein) are described. The compoun... | 03/11/2003 |
| 6384215 | Preparation of new intermediates and their use in manufacturing of cephalosporin compounds The present invention provides new thioester derivatives of 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (I), also, the invention provides a method by which the said thioester derivatives can be prepared by reacting 4-halogeno-... | 05/07/2002 |
| 6136827 | Cyclic amine modulations of chemokine receptor activity The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compou... | 10/24/2000 |
| 5955501 | Protein kinase C modulators O Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.... | 09/21/1999 |
| 5770591 | Bis-platinum complexes as chemotherapeutic agents A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, substituted dicarboxylate prim... | 06/23/1998 |
| 5728691 | Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as the pharmaceutical compositions containing them are descr... | 03/17/1998 |
| 5506243 | Sulfonamide derivatives Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as remedies for muscular dystrophy, cataract, myocardial infar... | 04/09/1996 |
| 4908452 | Process for preparing nitriles A facile and mild process for the preparation of nitriles from reagent sensitive primary carboxamides is described. The process utilizes a (carboxysulfamoyl)ammonium hydroxide compound as the dehydrating agent. It is useful for preparing nitriles which ha... | 03/13/1990 |
| 4716232 | 1-(vinyl phosphonate adduct) pyrazolidinones 1-(Vinyl phosphonate adduct) pyrazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.... | 12/29/1987 |
| 4659857 | Insecticidal cinnamamide compounds and method for controlling insects therewith The present invention relates to novel cinnamamide compounds and a process for the preparation thereof. The compounds of the invention are useful for controlling insects and acarina.... | 04/21/1987 |
| 4404302 | Acylated hindered hexahydropyrimidines and their use as light stabilizing agents An acylated, hindered hexahydropyrimidine of the formula ##STR1## wherein R1, R2, R3 and R4 may be the same or different independently of each other and are alkyl having 1 to 6 carbon atoms, when unsubstitu... | 09/13/1983 |
| 4388326 | Phenyl hydroxypropyl sulfoxide enzyme inhibitors Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or Kcat type.... | 06/14/1983 |
