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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8076477 | Adsorbents for protein purification Use of an affinity adsorbent for the separation, removal, isolation, purification, characterisation, identification or quantification of a proteinaceous material, wherein the affinity adsorbent is a compound of formula (III), wherein R1 is H, alkyl, aryl,... | 12/13/2011 |
| 8030484 | Substituted triazines as prion protein ligands and their use to detect or remove prions Compounds of formula (I) wherein R1 and R2 are the same or different and are each optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl groups; R3 is hydroge... | 10/04/2011 |
| 8026359 | Fungicidal heterocyclic amines Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein R1, R2, R9a, R9b, G, W, X, Y, and Z are as defined in the disclosure.... | 09/27/2011 |
| 8022208 | Benzene derivative or salt thereof Problem: To provide compounds which have an anticoagulation effect based on their ability to inhibit the activated blood coagulation factor X and are useful as coagulation inhibitors or agents for prevention or treatment for diseases caused by thrombi or emboli.... | 09/20/2011 |
| 8017769 | Colorless water-soluble organic luminophores and intermediates thereof Benzazole substituted aminobenzenesulfonate derivatives of formula (A) (wherein X, Q and M are as defined in the specification) are useful as components of water-soluble fluorescent inks and dyes invisible in day-light. Novel intermediates for the above compounds ar... | 09/13/2011 |
| 7888504 | Glucokinase activators and methods of using same Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; | 02/15/2011 |
| 7354921 | Pyrazolotriazines as kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or mor... | 04/08/2008 |
| 7332227 | Non-volatile lubricant system for medical devices A non-volatile lubricious coating composition is provided for use with medical devices, such as hypodermic needles, catheters, and the like. The coating composition includes a first siloxane polymer having a very low viscosity less than about 50 centistokes, a secon... | 02/19/2008 |
| 7329658 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ... | 02/12/2008 |
| 7223759 | Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of using such compounds in the treatment of bacterial infections in mammal... | 05/29/2007 |
| 7186797 | Polypeptide conjugates with extended circulating half-lives The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit ... | 03/06/2007 |
| 7183273 | Chemokine receptor binding heterocyclic compounds Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor. ... | 02/27/2007 |
| 7166602 | Pyrazolotriazines as kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or mor... | 01/23/2007 |
| 7153961 | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist The present invention provides 4-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-[1,5-a]-pyrazolo-1,3,5-triazine benzenesulfonate salt and a crystalline polymorph thereof. Further provided are pharmaceutical compositions containing the salt and ... | 12/26/2006 |
| 7109329 | Neurologically active compounds and compounds with multiple activities This invention provides pharmacologically active compounds having neurological and other bio-active capability. These active compounds comprise the derivatives of guanidino, aminoguanidino, 2-imadazolino, 2-hydrazinoimidazolino or 2-guanidinobenzimidazolino groups. | 09/19/2006 |
| 7071177 | P-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. ... | 07/04/2006 |
| 7038045 | Pyrazolotriazines as kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or mor... | 05/02/2006 |
| 7015221 | 2,4-disubstituted triazine derivatives This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2... | 03/21/2006 |
| 7002011 | Process for the preparation of 2-amino-4-chloro-1,3,5-triazines Compounds of the formula (I) or salts thereof are suitable for preparing active substances from the from the class of the aminotriazines of the formula (IV), for example herbicidal active substances. The compounds (I) c... | 02/21/2006 |
| 6943161 | Pyrimidine and triazine kinase inhibitors Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed. In one embodiment, the compounds are represented by Formula I, As selective inhibitors of inappropriat... | 09/13/2005 |
| 6943249 | Methods for isolating crystalline Form I of 5-azacytidine The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compos... | 09/13/2005 |
| 6936600 | Sorbitol dehrydrogenase inhibitors This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to... | 08/30/2005 |
| 6906067 | N-heterocyclic inhibitors of TNF-α expression N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutica... | 06/14/2005 |
| 6894047 | Triazine compounds useful as sorbitol dehydrogenase inhibitors This invention is directed to sorbitol dehydrogenase inhibitory compounds of formula I wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to phar... | 05/17/2005 |
| 6869943 | Sorbitol dehydrogenase inhibitors This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, wherein R1, R2 and R3 are as defined in the specification. This invention is also directed to... | 03/22/2005 |
| 6828338 | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the ... | 12/07/2004 |
| 6818726 | Polymers from hydroxyalkyl amino triazines and polyfunctional compounds Polymers are prepared from A) 60 to 95 percent by weight of a mixture including A1) 20 to 70 percent by weight of hydroxyalkyl amino triazines and A2) 30 to 80 percent by weight of ... | 11/16/2004 |
| 6806268 | Method for treating glaucoma V Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula IA and or IB: ... | 10/19/2004 |
| 6750348 | Chemokine receptor binding heterocyclic compounds This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, in... | 06/15/2004 |
| 6727251 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula II: wherein Z1 is nitrogen or CR8; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, ... | 04/27/2004 |
| 6693121 | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention... | 02/17/2004 |
| 6677451 | Preparation of sterically hindered amine ethers A new process is described for the preparation of a compound of the formula I ##STR1## wherein R1, R2, R3 and R4, independently of each other, are C1 -C8 alkyl or C1 -C5... | 01/13/2004 |
| 6677339 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: ##STR1## in which: Ar1 is an aromatic or heteroaromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar2 is an optionall... | 01/13/2004 |
| 6677353 | Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 01/13/2004 |
| 6638932 | 2,4-disubstituted triazine derivatives This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein --a1.dbd.a.sup.2 --a3.dbd.a.sup.4... | 10/28/2003 |
| 6624180 | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain protea... | 09/23/2003 |
| 6613104 | Process for preparing dyes and/or brightener formulations The invention relates to optical brighteners that possess at least one free SO3 H group and their use for whitening materials containing cellulose.... | 09/02/2003 |
| 6555683 | Condensation products based on amino-s-triazines and the use thereof In the proposed condensation product based on amino-s-triazines with at least two amino groups, formaldehyde and sulphite, the molar ratio of amino-s-triazine, formaldehyde and sulphite is 1:2.5-6.0:1.51-2.0 and the formiate content is less than 0.3 wt %.... | 04/29/2003 |
| 6518453 | Method for stabilizing chemical compounds containing at least one ethylenically unsaturated bond in order to prevent undesirable radical polymerization In a process for stabilizing chemical compounds having at least one ethylenically unsaturated bond to undesired free radical polymerization, a nitroxyl radical and a chemical compound containing phosphorus in chemically bonded form are added to the unsatu... | 02/11/2003 |
| 6482815 | Organic-arsenic compounds Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.... | 11/19/2002 |
