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| Number | Title | Issue Date |
| 8188272 | Fused heterocyclic compounds useful as kinase modulators Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, [PLEASE INSERT CHEMICAL STRUCTURE HERE] (I) are useful as kinase modulators, including Btk modulation, wherein R1, R2, R4, Q, Y, A and D are as defined ... | 05/29/2012 |
| 8138337 | Reverse-turn mimetics and method relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range o... | 03/20/2012 |
| 8101751 | Reverse-turn mimetics and method relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic a... | 01/24/2012 |
| 8080657 | Compounds of reverse turn mimetics and the use thereof Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures ... | 12/20/2011 |
| 8071764 | Compounds of reverse turn mimetics and the use thereof (2) Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic frame-work are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures... | 12/06/2011 |
| 8049008 | Reverse-turn mimetics and method relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range o... | 11/01/2011 |
| 7977478 | Polymorphic forms of vardenafil Crystalline polymorphic forms of vardenafil and vardenafil hydrochloride, and processes for preparing them. ... | 07/12/2011 |
| 7943767 | Fused bicyclic mTOR inhibitors Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer. ... | 05/17/2011 |
| 7932384 | Reverse-turn mimetics and method relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic a... | 04/26/2011 |
| 7915408 | Triazolotriazines as kinase inhibitors The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pa... | 03/29/2011 |
| 7834179 | Spiroindolinone derivatives There are provided spiroindolinone derivatives of the formula and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4 and R are as herein described. The co... | 11/16/2010 |
| 7629459 | Azo dye compound A compound represented by formula (I): Formula (I) wherein Z1 is atoms necessary for forming an aromatic ring; Z2 is atoms necessary for forming an aromatic hetero ring; V1 and V... | 12/08/2009 |
| 7419978 | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b | 09/02/2008 |
| 7388019 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV en... | 06/17/2008 |
| 7358256 | ATP competitive kinase inhibitors The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 th... | 04/15/2008 |
| 7326475 | Material for organic electroluminescent device, organic electroluminescent device, illuminating device and display The present invention provides: an organic EL element exhibiting high luminance, a high external quantum efficiency and a long high temperature driving life at 50° C.; an illuminator and a display device employing the organic EL element; and a material preferably u... | 02/05/2008 |
| 7323472 | 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds The present invention is directed to the novel use of a CSBP/p38 inhibitor for the treatment, including prophylaxis of inflammation enhanced cough in a mammal in need thereof. ... | 01/29/2008 |
| 7317012 | Bicyclic heterocycles as cannabinoind-1 receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 01/08/2008 |
| 7314934 | 4-amino substituted-6-aryl/heteroaryl substituted-2-methylsulfanyl-pyrimidine-5-carbaldehyde intermediates Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 01/01/2008 |
| 7314881 | 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 01/01/2008 |
| 7254022 | Cooling system for equipment and network cabinets and method for cooling equipment and network cabinets The invention relates to a cooling system for equipment and network cabinets and to a method for cooling such cabinets, together with the electronic modules located therein. In order to achieve with extremely simple means and particularly low capital and oper... | 08/07/2007 |
| 7253167 | Tricyclic-heteroaryl compounds useful as kinase inhibitors The present invention relates to compounds having the formula, wherein, Q is optionally substituted aryl or heteroaryl, R1 is hydrogen or C1-4alkyl, and R2, R3, R4... | 08/07/2007 |
| 7241763 | 3-furanyl analogs of toxoflavine as kinase inhibitors The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m, n, R1, R2 | 07/10/2007 |
| 7232822 | Reverse-turn mimetics and method relating thereto Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic a... | 06/19/2007 |
| 7202243 | Substituted imidazotriazines The invention relates to new substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of sch... | 04/10/2007 |
| 7199121 | Protein tyrosine phosphatase inhibitor Use of a compound of formula (I): wherein each R, which are the same or different, is H or C1–C6 alkyl, and X completes a ring which is a substituted triazine hav... | 04/03/2007 |
| 7196095 | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds Compounds of formula (I) and pharmaceutically acceptable salts thereof are useful in the treatment of cytokine mediated diseases such as arthritis and in the treatment and/or prevention of protozoal diseases such as coccidiosis | 03/27/2007 |
| 7176203 | Imidazo-triazine derivatives as ligands for gaba receptors A class of imidazo[1,2b][1,2,4]triazine derivatives, substituted at the 7-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having good affinity for t... | 02/13/2007 |
| 7122548 | Triazolotriazine compounds and uses thereof The present invention relates to compounds of the Formula (I), and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as canc... | 10/17/2006 |
| 7115602 | Heterocycles 3 The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. ... | 10/03/2006 |
| 7098207 | Imidazotriazinones and the use thereof Novel imidazotriazinones of general formula a method for the production and the pharmaceutical use thereof are disclosed. ... | 08/29/2006 |
| 7087605 | 5-Ethyl-imidazotriazinones The invention relates to novel 5-Ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. ... | 08/08/2006 |
| 7074790 | 5-ethylimidarotriazones The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. ... | 07/11/2006 |
| 7056936 | Synergistic combination The invention relates to the combined administration of PDE inhibitors and β2 adrenoceptor agonists for the treatment of respiratory tract disorders. ... | 06/06/2006 |
| 7037910 | Azabicyclic heterocycles as cannabinoid receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 05/02/2006 |
| 7037909 | Tetracyclic compounds as c-Met inhibitors The present invention relates to compounds of the Formulae (I) and (II), wherein R1-R10 and G are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be usefu... | 05/02/2006 |
| 7022847 | Method for the production of 2-(2-ethoxyphenyl)-substituted imidazotriazinones The invention relates to a method for the production of 2-phenyl-substituted imidazotriazinones of general formula (I), comprising the reaction of compounds of formula (II) with compounds of formula (III) and subsequent reaction with iodine or bromine, then with a m... | 04/04/2006 |
| 7005431 | Imidazo-triazine derivatives as ligands for gaba receptors A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, and substituted on ... | 02/28/2006 |
| 6998402 | Substituted imidazotriazinones The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness. ... | 02/14/2006 |
| 6998483 | Process for the preparation of sulphonamide-substituted imidazotriazinones The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) | 02/14/2006 |
