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| Number | Title | Issue Date |
| 8153786 | Synthesis of azido heterocycles Energetic candidate azido heterocycles and their synthesis are described. ... | 04/10/2012 |
| 8022207 | Compound having affinity to amyloid The invention relates to a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagenicity, and also relates to a low-toxic diagnostic agent for Alzheimer's disease containing the co... | 09/20/2011 |
| 7615632 | Crystalline forms of temozolomide Disclosed are novel crystalline forms of Temozolomide, methods of preparation thereof, medicaments including the novel crystalline forms of Temozolomide, and uses thereof in the treatment of medical conditions. ... | 11/10/2009 |
| 7612202 | Process for preparing temozolomide The present invention provides a process for preparing highly pure Temozolomide base which includes recovery from the purification mother liquors by using an anionic exchange resin. By treating Temozolomide hydrochloride with a mixture of an organic acid, a water mi... | 11/03/2009 |
| 7425629 | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein. ... | 09/16/2008 |
| 7388019 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV en... | 06/17/2008 |
| 7329651 | Cannabimimetic ligands Disclosed are heterocyclic compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a c... | 02/12/2008 |
| 7329757 | Substituted iminoazines The invention relates to novel substituted iminoazines of the general formula (I) in which R1, R2, R3, R4, Z1, Z2 and Z3 a... | 02/12/2008 |
| 7301028 | Mitotic kinesin inhibitors The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which com... | 11/27/2007 |
| 7256287 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-aza-benzimidazole molecules tha... | 08/14/2007 |
| 7250512 | Electroluminescent iridium compounds having red-orange or red emission and devices made with such compounds The present invention is generally directed to electroluminescent Ir(III) complexes which have emission maxima in the red-orange to red region of the visible spectrum and devices that are made with the Ir(III) complexes. ... | 07/31/2007 |
| 7238437 | Light-emitting material comprising orthometalated iridium complex, light-emitting device, high efficiency red light-emitting device, and novel iridium complex A light-emitting material comprises a compound having a partial structure represented by the following formulas (8), (20) and tautomers thereof: wherein the variables are as defined in the specification. ... | 07/03/2007 |
| 7230139 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid... | 06/12/2007 |
| 7220328 | Low-smoke gas generating low order pressure pulse compositions Low-smoke gas generating compositions for producing a low order pressure pulse use a salt or complex of a triazolyl-tetrazinyl-triazine compound. The general chemical structure of the triazolyl-tetrazinyl-triazine is: ... | 05/22/2007 |
| 7217844 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid... | 05/15/2007 |
| 7186843 | Aminomethylpyrrolidine derivatives having aromatic substituents This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R1 is an optionally substituted aromatic group, a salt of th... | 03/06/2007 |
| 7173021 | Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers This invention relates to the use of temozolomide esters (4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylate esters) Formula 1 as potent anticancer pro-drugs for treatment of cancers by topical and transdermal applications, and to a novel process... | 02/06/2007 |
| 7166368 | Electroluminescent platinum compounds and devices made with such compounds The present invention is generally directed to electroluminescent Pt(II) complexes which have emission maxima across the visible spectrum, and devices that are made with the Pt(II) complexes. ... | 01/23/2007 |
| 7148221 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an... | 12/12/2006 |
| 7087751 | Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process. ... | 08/08/2006 |
| 7064201 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an in... | 06/20/2006 |
| 7057049 | Process for making substituted pyrazoles This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): | 06/06/2006 |
| 7052783 | Oxadiazole tetramers This invention relates to tetraphenylmethane-based oxadiazole molecules that act as electron transporting materials to be used in electroluminescent devices. The oxadiazole compounds are of the following formula. Each variable is defined in the specification. | 05/30/2006 |
| 6992741 | Bistable nematic liquid crystal device A bistable nematic liquid crystal device includes an array of holes (8) in an alignment layer (6) on at least one cell wall (2). The alignment layer (6) induces a substantially planar local alignment of liquid crystal molecules. The holes... | 01/31/2006 |
| 6900206 | Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with sulfonylureido piperazine derivatives of Formula I. These compounds possess unique antivir... | 05/31/2005 |
| 6900213 | Bisaryl derivatives having FSH modulatory activity The invention relates to bisaryl derivatives of the formula I, wherein (R,R) is selected from (H,H), O, (H,CH3), (H,OH) and (H,CN); Ar is substituted phenyl and A is a group of formula II, III, IV ... | 05/31/2005 |
| 6852249 | Prismatic supramolecules This invention features a supramolecule having the following structures: M is a transition metal atom that is rhenium (Re), manganese (Mn), chromium (Cr), molybdenum (Mo), tungsten (W), iron (Fe), ruthenium (Ru), or os... | 02/08/2005 |
| 6846926 | Triazolyl-aminotriazine compositions, including salts The present invention includes a salt compound having the chemical formula: having a tricyclic structure with the third ring having either six or seven atoms. | 01/25/2005 |
| 6844434 | Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of temozolomide, an antitumor compound, and to intermediates useful in this novel process. ... | 01/18/2005 |
| 6794518 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer ... | 09/21/2004 |
| 6683028 | Cyclic guanidine derivatives and their use as pesticides The invention relates to novel guanidine derivatives of the formula (I) ##STR1## in which A, R1, R2, R3 and Z are as defined in the description, to a process for their preparation and to their use for controlling animal ... | 01/27/2004 |
| 6677339 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: ##STR1## in which: Ar1 is an aromatic or heteroaromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar2 is an optionall... | 01/13/2004 |
| 6673924 | 1,2,4-triazolol[4,3-a][1,3,5]triazine-3,5,7-substituted precursor, and process, and compounds therefrom The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5] Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5] Triazine-3,5,7-Triamine, and novel fused ring structures such as triazolyl-tetrazinyl-aminotria... | 01/06/2004 |
| 6657059 | 3,6BIS(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine or salt thereof The compound 3,6-bis(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine and its salts are provided together with a propellant composition including an oxidizer, a binder and 3,6-bis(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine or its salts.... | 12/02/2003 |
| 6632305 | 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-substituted precursor, and process, and compounds therefrom The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine-3,5,7-Triamine, and novel fused ring structures such as triazolyl-tetrazinyl-aminotriazi... | 10/14/2003 |
| 6624171 | Substituted aza-oxindole derivatives Substituted aza-oxindole derivatives useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiati... | 09/23/2003 |
| 6610677 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII: ##STR1## wherein Z1 is N or C--R9, Z2 is N or CH, and Z3 is N or C--Rx | 08/26/2003 |
| 6602889 | 5-heteroaryl substituted indoles The present invention relates to compounds having general formula (I) as defined herein, or a pharmaceutically acceptable acid addition salt thereof. The compounds are selective 댑 -adrenoceptor ligands. ##STR1##... | 08/05/2003 |
| 6602366 | Triazolyl-tetrazinyl-aminotriazine compounds useful in pyrotechnic compositions and process thereof Pyrotechnic compositions use a salt or complex of a triazolyl-tetrazinyl-aminotriazine compound. The general chemical structure of the triazolyl-tetrazinyl-aminotriazine is: ##STR1## with values of the variables defined within the disclosure.... | 08/05/2003 |
| 6573262 | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, ##STR1## compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.... | 06/03/2003 |
