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| Number | Title | Issue Date |
| 7135470 | Thienopyridazines as IKK inhibitors The invention provides compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: A, Y, Z and R1 are as defined herein. Also provided are compositions comp... | 11/14/2006 |
| 7115779 | Softener composition A softener composition, which contains tri-long-chain alkyl quaternary ammonium salt that has been considered to be difficult to use as a softener base agent, and which can provide a softener composition that provides a sufficient softening performance, is provided ... | 10/03/2006 |
| 7012064 | Cyclosporins for the treatment of immune disorders The present invention relates to methods of treating or preventing an inflammatory or immune disorder in a subject while eliminating or reducing the toxicity associated with the administration of cyclosporin A, comprising systemically administering to said subject a... | 03/14/2006 |
| 7012065 | Cyclosporins for the treatment of immune disorders The present invention relates to novel semi-synthetic cyclosporin analogs for the prevention of organ transplantation rejection and the treatment of immune disorders and inflammation, their use as pharmaceuticals and pharmaceutical composition comprising them, as we... | 03/14/2006 |
| 6995139 | Cyclic undecapeptide pro-drugs and uses thereof A pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue, useful as a medicinal product, including use for treatment of pathological conditions of the eye. ... | 02/07/2006 |
| 6979671 | Cyclosporins for the treatment of immune disorders The present invention relates to a cyclosporin analog of the following formula (I) or its pro-drug or pharmaceutically acceptable salt: In formula I, the formula for residue A is: ... | 12/27/2005 |
| 6749988 | Amine compounds, resist compositions and patterning process Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enh... | 06/15/2004 |
| 6403793 | Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1-[3. 5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-(4-fluorophenyl)-4-(phenylmeth yl) mopholine. This compound is useful as an intermediate in the synthesis ... | 06/11/2002 |
| 6177427 | Treatment of glaucoma and ocular hypertension Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed.... | 01/23/2001 |
| 6113815 | Ether-stabilized organosilane compositions and methods for using the same The composition formed by mixing an organosilane with an ether. Water-stabilized organosilane compounds. A water stable composition made from the ether and organosilane composition and water. A method of treating a substrate by mixing or contacting the su... | 09/05/2000 |
| 6057443 | Dimorpholinodiethylether having improved isocyanate stability Dimorpholinodiethylether is treated with hydrogen over a reducing catalyst to improve its isocyanate stability.... | 05/02/2000 |
| 5959103 | Naphthofluorene compounds, intermediates, compositions, and methods The invention provides naphthofluorene compounds, intermediates, formulations, processes, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions, including hyperlipidemia, and estr... | 09/28/1999 |
| 5935585 | Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment ... | 08/10/1999 |
| 5910508 | Polycyclic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic polyenic compounds have the structural formula (I): ##STR1## and are useful for modulating cellular hormone receptors.... | 06/08/1999 |
| 5872117 | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebro... | 02/16/1999 |
| 5614548 | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions Quaternary amine-containing ether lipid analogs of the formula R1 --X--R2 --N+ (R3) (R4) (R5) Z- are disclosed. R1 represents a hydrophobic group and R2 represents th... | 03/25/1997 |
| 5354901 | Perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluorides and derivatives thereof Perfluoro(cycloaliphatic methyleneoxyalkylene) compositions are provided. These compositions comprise perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluoride compounds having (a) a perfluorocycloaliphatic moiety which can have up to two perfluoro... | 10/11/1994 |
| 5245032 | Catalytic processes for the preparation of N,N,N-trisubstituted nitrogen-containing compounds A process for preparing N,N,N-trisubstituted nitrogen-containing compounds which comprises contacting a carboxylated N,N,N-trisubstituted nitrogen-containing compound with a mixed metal oxide catalyst under conditions effective to produce the N,N,N-trisub... | 09/14/1993 |
| 5214142 | Processes for the preparation of aminoethers A process for preparing aminoethers, particularly bis[2-(N,N-dialkylamino)alkyl]ethers, which comprises contacting a carboxylated aminoether with a metal oxide catalyst under conditions effective to produce the aminoether. Many of these aminoethers are us... | 05/25/1993 |
| 5210282 | Perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluorides and derivatives thereof Perfluoro(cycloaliphatic methyleneoxyalkylene) compositions are provided. These compositions comprise perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluoride compounds having (a) a perfluorocycloaliphatic moiety which can have up to two perfluoro... | 05/11/1993 |
| 5185334 | 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds... | 02/09/1993 |
| 5183889 | Benzonaphtahalene derivatives, a process for their preparation and their use in therapeutic and cosmetic compositions A benzonphthalene compound has the formula ##STR1## wherein R1 represents ##STR2## or (ii) --CH2 OH; R6 represents ##STR3## or OR7 wherein R7 represents hydrogen, alkyl having 1-20 carb... | 02/02/1993 |
| 5164497 | Decarboxylation processes using mixed metal oxide catalysts A decarboxylation process which comprises contacting a carboxylated compound with a metal oxide catalyst under conditions effective to decarboxylate the carboxylated compound.... | 11/17/1992 |
| 5126374 | Fungicidal guanidines Guanidines I ##STR1## (A=C5 -C12 -cycloalkyl which may bear up to three further substituents; benzyl substituted in the para-position; R1, R2, R3 =H, C1 -C4 -alkyl; R4 | 06/30/1992 |
| 5095021 | Phenylalkylamines and fungicides containing these Phenylalkylamines of the formula ##STR1## where n is 5, 6, 7, 8 or 9, m is 1, 2 or 3, R1 is methyl, halogen, substituted or unsubstituted aryl or substituted or unsubstituted phenoxy, and, when m is 2, two adjacent radicals R1 t... | 03/10/1992 |
| 5089614 | Polysubstituted 2-morpholones An essentially single stage reaction has been discovered in which a disubstituted ethanolamine, that is, a 2,2'-substituted-2-aminoethanol, may be reacted with a haloform and a carbonyl containing compound selected from the group consisting of monoketones... | 02/18/1992 |
| 5082840 | Morpholine compounds and treatment A method for increasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal survival rate of livestock comprises the administration to lives... | 01/21/1992 |
| 5071851 | Fungicidal cyclohexylamines 4-substituted cyclohexylamines of the formula ##STR1## where R is the group CR1 R2 R3, where R1, R2 and R3 are hydrogen, unsubstituted or substituted alkyl, alkoxy, alkylthio or cycloa... | 12/10/1991 |
| 5068452 | Aromatic aldehydes and their derivatives Aromatic aldehydes of formula ##STR1## possessing a single or a double bond in the position indicated by the dotted line and wherein symbol X represents a monovalent radical or formula ##STR2## or, when the dotted line represents a single b... | 11/26/1991 |
| 5001156 | Lipophilic quaternary ammonium salicylates, their use in cosmetics and in dermopharmacy Lipophilic quaternary ammonium salicylate, characterized in that it corresponds to the formula: ##STR1## in which: (i) R1, R2, R3 and R4, which may be identical or different, denote an alkyl or alkylcycloal... | 03/19/1991 |
| 4999361 | Trisubstituted amines, pharmacologically acceptable salts thereof and pharmaceutical compositions containing them The present invention provides compounds of the general formula ##STR1## wherein R1 is a hydrogen atom, a straight-chained or branched C1 -C12 -alkyl radical, a C3 -C7 -cycloalkyl radical, a stra... | 03/12/1991 |
| 4946880 | Silylated U.V. stabilizers containing hindered tertiary amines Reactive stabilizer compounds, to be used in the stabilization of organic polymers, contain a sterically hindered, N-substituted piperidinic, morpholinic or pyrrolidinic group, and at least a hydrolysable silicic function. Such compounds give rise, by hyd... | 08/07/1990 |
| 4940573 | Cationic surface-active compounds Cationic surface-active products of the formula: ##STR1## in which R1 =C4 -C20 aliphatic radical, R2 =C4 -C20 alkyl, alkoxymethyl or alkenyloxy radical, p=1-2.5, n=2-20 and G denotes a... | 07/10/1990 |
| 4910304 | Preparation of N-substituted cyclic amines N-substituted cyclic amines of the general formula I ##STR1## where A is an alkylene group or a --(CH2)n --[--O--(CH2)m ]r group which may be monosubstituted or polysubstituted by radicals R with... | 03/20/1990 |
| 4904825 | Quaternary ammonium antistatic compounds Described are certain quaternary ammonium alkyl benzene sulfonate salts and certain quaternary ammonium alkane sulfonate salts, e.g., octyl dimethyl hydroxyethyl ammonium dodecyl benzene sulfonate and octyl dimethyl hydroxyethyl ammonium methane sulfonate... | 02/27/1990 |
| 4902818 | Process for the manufacture of optically active compounds The manufacture of optically active bifunctional compounds of the general formula ##STR1## wherein R represents protected hydroxymethyl, protected formyl or alkoxycarbonyl and R1 represents a group of the formula ##STR2## in whic... | 02/20/1990 |
| 4889953 | Glycerol derivatives, their production and use Compounds of the formula: ##STR1## wherein R1 is a higher alkyl group which may be substituted; R2 is a hydrogen, a lower alkyl group which may be substituted, a lower alkanoyl group which may be substituted or a lower alkylthio... | 12/26/1989 |
| 4889656 | Perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluorides and derivatives thereof Perfluoro(cycloaliphatic methyleneoxyalkylene) compositions are provided. These compositions comprise perfluoro(cycloaliphatic methyleneoxyalkylene) carbonyl fluoride compounds having (a) a perfluorocycloaliphatic moiety which can have up to two perfluoro... | 12/26/1989 |
| 4820820 | Cationic surface-active compounds Cationic surface-active products of the formula: in which R1 =C4 -C20 aliphatic radical, R2 =C4 -C20 alkyl, alkoxymethyl or alkenyloxy radical, p=1-2.5, n=2-20 and G denotes an amine or amine ox... | 04/11/1989 |
| 4758564 | Ether and thioether amines and their use as fungicides Amines of the general formula ##STR1## where A is alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenylalkyl or phenylalkenyl, X is oxygen or sulfur, B is an alkylene chain and R1 and R2 are each alkyl, alkenyl or cycloalkyl, or R | 07/19/1988 |
