Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7262325 | Method of preparing salicylamides The present invention provides a fast, high yield method for preparing salicylamide intermediates. The method comprises reacting a C4 or higher alkyl ester of salicylic acid or derivative thereof with at least one amine selected from the group consisting ... | 08/28/2007 |
| 7262296 | Substituted aryl alkenoic acid heterocyclic amides The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value bu... | 08/28/2007 |
| 7166600 | Thiocarbamate inhibitors of alpha-4 integrins The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1 | 01/23/2007 |
| 7125871 | Excitatory amino acid receptor modulators Compounds of the formula (I) in which R1, R2 and X1 have the meanings given in the specification, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system ... | 10/24/2006 |
| 7115728 | Human peroxisome proliferator activated receptor γ The present invention relates to a novel human peroxisome proliferator activated receptor, hPPARγ. hPPARγ differs from the mouse peroxisome proliferator activated receptor γ in the nucleotide sequence and the amino acid sequence. The invention provides isolated, ... | 10/03/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7057040 | Substituted aryl alkenoic acid heterocyclic amides The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value bu... | 06/06/2006 |
| 7015323 | Thiocarbamate inhibitors of alpha-4 integrins The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to corresponding carbamate compounds wherein substituents L, X, Y, Z, R1 | 03/21/2006 |
| 6946576 | Method for preparing nitrogen-containing compounds A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not o... | 09/20/2005 |
| 6790955 | Processes for the preparation of aminophenylsulfonyl-ureas and intermediate products for the processes The invention relates to the preparation of compounds (I) in which A═H or acyl and R1, R2, R3, R, n, X, Y and Z are as defined in claim 1 by halogenation and rearrangement of compounds ... | 09/14/2004 |
| 6774086 | 3-Aminocarbonyl-substituted benzoylcyclohexanediones There are described derivatives of benzoylcyclohexanediones of the formula (I) and their use as herbicides. In this formula (I), R1a, R1b, R1c, R2, R3, R4 | 08/10/2004 |
| 6700025 | Process for stereoselective synthesis of prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.... | 03/02/2004 |
| 6649612 | Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them Compounds of formula (I): ##STR1## in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R | 11/18/2003 |
| 6649616 | Substituted phenylcyclohexanecarboxamides and their use The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) ##STR1## to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.... | 11/18/2003 |
| 6573387 | Synthesis of ,ଲ-substituted amino amides, esters, and acids ,ଲ-Unsaturated amides and esters are converted to ,ଲ-substituted amino amides, esters, and acids. An ,ଲunsaturated amide or ester is first converted to an ,ଲ-hydroxysulfonamide or hydroxycarbamate amide ... | 06/03/2003 |
| 6566553 | Synthesis of clasto-lactacystin ଲ-lactone and analogs thereof The present invention is directed to an improved synthesis of clasto-lactacystin-ଲ-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies u... | 05/20/2003 |
| 6534652 | Intermediates for the preparation of substituted 1,2,3,4-tetrahydronaphthalene derivatives The present invention relates to new piperidyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula I ##STR1## wherein X is N or CH; Y is NR2 CH2, CH2 --NR2, NR2 --... | 03/18/2003 |
| 6531471 | Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest... | 03/11/2003 |
| 6506939 | Production of acrylic monomers A process for the preparation of a mixture comprising a compound of formula (1) and a compound of formula (2) ##STR1## wherein R1 is an optionally substituted C1-20 alkyl, optionally substituted C3-4 alkenyl, optionally su... | 01/14/2003 |
| 6362182 | Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest... | 03/26/2002 |
| 6358885 | Substituted phenylheterocyclic herbicides This invention relates to certain phenylheterocyclic compounds, herbicidal compositions thereof and a method for their use as general and selective preemergent or postemergent herbicides or plant growth regulants.... | 03/19/2002 |
| 6316475 | Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications Compounds of formula (I) ##STR1## are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands.... | 11/13/2001 |
| 6218390 | Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest... | 04/17/2001 |
| 6207716 | Non-steroidal ligands for the estrogen receptor Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/27/2001 |
| 6200972 | Heterocyclic esters and amides This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particular... | 03/13/2001 |
| 6159973 | Aromatic amides, their preparation process, the compositions containing them and their use as pesticides The subject of the invention is the compounds of formula (I): Q(CH2)a --(X1)b --Q1 --Q2 --C(X2)--N(R1)(R2) (I) in which: Q represents an aryl ... | 12/12/2000 |
| 6107494 | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions... | 08/22/2000 |
| 6069247 | Process for preparing substituted acrylamides by reaction of propiolamides and aromatic rings The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.... | 05/30/2000 |
| 6020332 | Fluorine-containing diphenyl acrylamide antimicrobial agents Fluorine-containing diphenyl acrylamide of general formula (I) have antimicrobial properties. wherein R1 and R2 are independently selected from (C1 -C6)alkyl group, alkyl group, (C1 -C6)alk... | 02/01/2000 |
| 5917038 | Process of preparing substituted acrylamides The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.... | 06/29/1999 |
| 5877219 | Non-steroidal ligands for the estrogen receptor Described herein are non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/02/1999 |
| 5869663 | Substituted heterocyclic compounds The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH | 02/09/1999 |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
| 5703076 | Retroviral protease inhibitors Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 12/30/1997 |
| 5686586 | Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula, X represents --CH.dbd.CH--, O or S, R1 represents hydrogen, branched alkyl having 3-... | 11/11/1997 |
| 5686435 | Vitamin D amide derivatives The invention pertains to vitamin D amide derivatives of formula (I). These novel 1-hydroxy vitamin D derivatives and their 20-epi analogues comprise compounds of formula (I) and corresponding 5,6-trans isomers, where Y represents an alkylene or al... | 11/11/1997 |
| 5681835 | Non-steroidal ligands for the estrogen receptor Prescribed herein are novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 10/28/1997 |
| 5635103 | Bleaching compositions and additives comprising bleach activators having alpha-modified lactam leaving-groups Improved cleaning and/or bleaching compositions including fabric laundry and bleaching compositions, automatic dishwashing compositions, hard surface cleaners, bleach additives and the like, suitable for domestic use, comprising improved bleach activators... | 06/03/1997 |
| 5554581 | Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient The present invention relates to 3,4,5,6-tetrahydrophthalamide derivatives and 3,4,5,6-tetrahydroisophthalimide derivatives having excellent effects as effective active ingredients of herbicides, and processes for preparing the same, and provides the comp... | 09/10/1996 |
| 5506190 | Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient The present invention relates to 3,4,5,6-tetrahydrophthalamide derivatives and 3,4,5,6-tetrahydroisophthalimide derivatives having excellent effects as effective active ingredients of herbicides, and processes for preparing the same, and provides the comp... | 04/09/1996 |
