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| Number | Title | Issue Date |
| 7939659 | Biological buffers with wide buffering ranges Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa'... | 05/10/2011 |
| 7459555 | Photochromic naphthopyrans The present invention relates to photochromic 2H-naphtho[1,2-b]pyrans as well as their use in synthetic resins of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic naphthopyran compounds, for which a further ... | 12/02/2008 |
| 7250516 | Phenylalanine derivatives Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 integrin i... | 07/31/2007 |
| 7247701 | Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxa... | 07/24/2007 |
| 7241916 | Process for producing methacrylic ester A method of producing a methacrylic acid ester which comprises carrying out an ester-exchange reaction between methyl methacrylate and an alcohol or a phenol while removing by-product methanol as an azeotropic mixture with methyl methacrylate from the reaction syste... | 07/10/2007 |
| 7220752 | Compounds active at the glucocorticoid receptor II This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, especially lowering blood glucose ... | 05/22/2007 |
| 7141560 | Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of th... | 11/28/2006 |
| 7030111 | Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 04/18/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6949664 | Trihydroxy polyunsaturated eicosanoids The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives of trihydroxy polyunsaturated eicosanoids that can be prepared according to ... | 09/27/2005 |
| 6946542 | Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxa... | 09/20/2005 |
| 6939855 | Anti-inflammatory compositions and method The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ... | 09/06/2005 |
| 6927294 | Nitrogen-containing heterocycles Functionalized nitrogen heterocyclic compounds, including benzodiazepines and azasugars, and synthetic methods for preparing such compounds. Nitrogen-containing heterocycles are prepared by reacting amino-carbonyl compounds that contain an amine moiety connected via... | 08/09/2005 |
| 6749988 | Amine compounds, resist compositions and patterning process Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enh... | 06/15/2004 |
| 6720319 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 04/13/2004 |
| 6700025 | Process for stereoselective synthesis of prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.... | 03/02/2004 |
| 6638930 | Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiov... | 10/28/2003 |
| 6608196 | Process for solid supported synthesis of pyruvate-derived compounds Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.... | 08/19/2003 |
| 6562815 | Morpholinones as light stabilizers The invention relates to new compounds containing 1-8 active groups of the type 3,3,6,6-polysubstituted 2-morpholinone and having the formula F (A'--Z)m --X (F), wherein m is a number from 1 to 8; X is an organic anchor group of valency m and in case th... | 05/13/2003 |
| 6479491 | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R | 11/12/2002 |
| 6479666 | Phenyl-keto-imidazolidine thioamide derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated wit... | 11/12/2002 |
| 6335333 | N-arylsulfonylamino acid omega-amides Compounds of the formula I: ##STR1## stereoisomeric forms, and physiologically tolerable salts thereof are suitable for the production of pharmaceuticals for the therapy and prophylaxis of disorders involving matrix-degrading metalloproteinases.... | 01/01/2002 |
| 6262060 | Azacycloalkane derivatives, preparation and therapeutic application The invention relates to azacycloalkane derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to methods for the treatment of hyperglycaemia, diabetes, obesity or inflammation utilizing them.... | 07/17/2001 |
| 6232467 | Method for the synthesis of amines and amino acids with organoboron derivatives Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.... | 05/15/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6207828 | Process for making 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates This invention provides a convenient, new, one step process for the preparation of 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates and related derivatives thereof by reaction of carbonyl compounds substituted with a trihaloacetyl group with an aceta... | 03/27/2001 |
| 6200972 | Heterocyclic esters and amides This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particular... | 03/13/2001 |
| 6172129 | Cyclic amine acrylate monomers and polymers (Meth)acrylate functional compound which is the reaction product of a cyclic secondary amine and a poly(meth)acrylate having at least three acrylate or methacrylate groups, useful for radiation curable coating or ink composition having low viscosity, low ... | 01/09/2001 |
| 6140326 | Morpholinones as light stabilizers The invention relates to new compounds containing 1-8 active groups of the type 3,3,6,6-polysubstituted 2-morpholinone and having the formula F (A'--Z)m --X (F), wherein m is a number from 1 to 8; X is an organic ... | 10/31/2000 |
| 6075146 | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals The invention relates to intermediates and processes for producing benzothiophenes employing hydroxylamines.... | 06/13/2000 |
| 6020489 | Cytoprotective fatty moiety compounds Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA2 and preventing oxidation. In particular, each compound has at leas... | 02/01/2000 |
| 6017918 | Phenyl glycine compounds and methods of treating atherosclerosis and restenosis The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions c... | 01/25/2000 |
| 6015899 | Liquid antioxidants as stabilizers Products are described which can be obtained by reacting components a), b) and c), where component a) is a compound of the formula I or a mixture of compounds of the formula I, component b) is a compound of the formula II or a mixture of compounds of the ... | 01/18/2000 |
| 6002002 | Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein: X is O, --NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substit... | 12/14/1999 |
| 5961991 | Melanoquaternary compounds and their use as hair dyes and for skin treatment Water soluble, cationic products useful as hair colorants or for the treatment of skin which are esters or amides formed by reaction of melanin and a quaternary salt containing a reactive amino or hydroxyl group, as well as compositions containing them an... | 10/05/1999 |
| 5962507 | O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R1 and R2 | 10/05/1999 |
| 5935585 | Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment ... | 08/10/1999 |
| 5929236 | 2-substituted morpholine and thiomorpholine derivatives as GABA-B antagonists Disclosed are compounds of the formula I wherein: Y represents --CO2 H, --CO2 R6, --C(O)NHR7, --SO2 H, --SO3 H, --SO3 R6, --SO2 NHR7, --C(O)--N(OH)--R... | 07/27/1999 |
| 5885984 | Aminocyclohexylesters and uses thereof Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com... | 03/23/1999 |
| 5861427 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is... | 01/19/1999 |
